Dose prostaglandin-mediated inflammation commit to pathology of Duchenne muscular dystrophy?

Research Project

Project/Area Number	23659521
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Pediatrics
Research Institution	Kobe Gakuin University
Principal Investigator	MATSUO Masafumi 神戸学院大学, 総合リハビリテーション学部, 教授 (10157266)
Project Period (FY)	2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords	筋ジス / ジストロフィン / PGD2 / 炎症
Research Abstract	Prostaglandin-mediated inflammation was examined in Duchenne muscular dystrophy by examing urinary prostaglandin D_2 metabolite and expression of prostaglandin D_2 synthesis in muscles. It was found that urinary excretion of tetranor PGDMwas elevated in Duchenne muscular dystrophy.