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New approaches of treating developmental disorders in channelopathy

Research Project

Project/Area Number 23659522
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionOkayama University

Principal Investigator

OHMORI Iori  岡山大学, 大学院・医歯薬学総合研究科, 助教 (20403488)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords発達障害 / チャネル病 / 神経伝達物質 / SCN1A遺伝子 / CACNA1A遺伝子 / チャネル異常
Research Abstract

Neurodevelopmental disorders includes mental retardation, autism spectrum disorder, learning disability, and attention deficit hyperactivity disorder. Molecules that modulate synaptic homeostasis are considered to be important substrates of pathogenesis in these disorders. This project reveals that dysfunction of neuronal channels also leads to neurodevelopmental disorders. These neuropsychiatric phenotypes are not caused by secondary effects of epileptic seizures or antiepileptic drugs.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (36 results)

All 2013 2012 2011 Other

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (13 results) Remarks (3 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 3 results)

  • [Journal Article] CACNA1A variants may modify the epileptic phenotype of Dravet syndrome.2013

    • Author(s)
      Ohmori I, Ouchida M, Kobayashi K, Jitsumori Y, Mori A, Michiue H, Nishiki T, Ohtsuka Y, Matsui H.
    • Journal Title

      Neurobiol Dis

      Volume: 50 Pages: 209-17

    • NAID

      120006765089

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhalation of 10% carbon dioxide rapidly terminates Scn1a mutation-related hyperthermia-induced seizures2013

    • Author(s)
      Ohmori I, Hayashi K, Wang H, Ouchida M, Fujita N, Inoue T, Michiue H, Nishiki T, Matsui H
    • Journal Title

      Epilepsy Res

      Volume: in press Issue: 1-2 Pages: 999-999

    • DOI

      10.1016/j.eplepsyres.2013.01.003

    • NAID

      120006765093

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] CACNA1A variants may modify the epileptic phenotype of Dravet syndrome.2013

    • Author(s)
      Ohmori I
    • Journal Title

      Neurobiol Dis.

      Volume: 50 Pages: 209-217

    • DOI

      10.1016/j.nbd.2012.10.016

    • NAID

      120006765089

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-frequency EEG oscillations in hyperthermia-induced seizures of Scn1a mutant rats.2012

    • Author(s)
      Kobayashi K
    • Journal Title

      Epilepsy Research

      Volume: 103 Issue: 2-3 Pages: 161-166

    • DOI

      10.1016/j.eplepsyres.2012.07.020

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acute encephalopathy with a novel point mutation in the SCN2A gene2012

    • Author(s)
      Kobayashi K, Ohzono H, Shinohara M, Saitoh M, Ohmori I, Ohtsuka Y, Mizuguchi M.
    • Journal Title

      Epilepsy Res

      Volume: 102(1-2) Issue: 1-2 Pages: 109-12

    • DOI

      10.1016/j.eplepsyres.2012.04.016

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Additional information regarding "Dravet syndrome: Inroads into understanding epileptic encephalopathies"2012

    • Author(s)
      Kobayashi K, Ohtsuka Y, Ohmori I.
    • Journal Title

      J Pediatr

      Volume: 160(3) Issue: 3 Pages: 532-3

    • DOI

      10.1016/j.jpeds.2011.11.058

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acute encephalopathy in children with Dravet syndrome.2012

    • Author(s)
      Okumura A, Uematsu M, Imataka G, Tanaka M, Okanishi T, Kubota T, Sudo A, Tohyama J, Tsuji M, Ohmori I, Naiki M, Hiraiwa-Sofue A, Sato H, Saitoh S, Shimizu T.
    • Journal Title

      Epilepsia

      Volume: 53 Issue: 1 Pages: 79-86

    • DOI

      10.1111/j.1528-1167.2011.03311.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acute encephalopathy with a novel point mutation in the SCN2A gene.2012

    • Author(s)
      Kobayashi K
    • Journal Title

      Epilepsy Res.

      Volume: 102 Pages: 109-112

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dravet syndrome: Inroads into understanding epileptic encephalopathies2012

    • Author(s)
      Kobayashi K
    • Journal Title

      J Pediatr

      Volume: 160 Pages: 532-533

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Additional information regarding "Dravet syndrome: Inroads into understanding epileptic encephalopathies"2012

    • Author(s)
      Kobayashi K, Ohtsuka Y, Ohmori I
    • Journal Title

      J Pediatr

      Volume: 160 Pages: 532-533

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antidepressant-like effect of sildenafil through oxytocin-dependent cyclic AMP response element-binding protein phosphorylation.2012

    • Author(s)
      Matsushita H, Matsuzaki M, Han XJ, Nishiki TI, Ohmori I, Michiue H, Matsui H, Tomizawa K.
    • Journal Title

      Neuroscience

      Volume: 200 Pages: 13-18

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ca(2+)-independent syntaxin binding to the C(2)B effector region of synaptotagmin.2012

    • Author(s)
      4)Masumoto T, Suzuki K, Ohmori I, Michiue H, Tomizawa K, Fujimura A, Nishiki TI, Matsui H.
    • Journal Title

      Mol Cell Neurosci

      Volume: 49 Pages: 1-8

    • NAID

      120005425639

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dravet syndrome with an exceptionally good seizure outcome in two adolescents.2011

    • Author(s)
      Kobayashi K, Ohmori I,Ouchida M, Ohtsuka Y.
    • Journal Title

      Epileptic Disord

      Volume: 13(3) Issue: 3 Pages: 340-4

    • DOI

      10.1684/epd.2011.0453

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The rapy for hyper ther mia-induced seizures in Scn1a mutant rats2011

    • Author(s)
      Hayashi K, Ueshima S, Ouchida M, Mashimo T, Nishiki T, Sendo T, Serikawa T, Matsui H, Ohmori I
    • Journal Title

      Epilepsia

      Volume: 52(5) Issue: 5 Pages: 1010-1017

    • DOI

      10.1111/j.1528-1167.2011.03046.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acute Encephalopathy in Children with Dravet Syndrome2011

    • Author(s)
      Okumura A, Uematsu M, Imataka G, Tanaka M, Okanishi T, Kubota T, Sudo A, Tohyama J, Tsuji M, Ohmori I, Naiki M, Hiraiwa-Sofue A, Sato H, Saitoh S, Shimizu T.
    • Journal Title

      Epilepsia

      Volume: 53 Pages: 79-86

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dravet syndrome with an exceptionally good seizure outcome in two adolescents.2011

    • Author(s)
      Kobayashi K, Ohmori I, Ouchida M, Ohtsuka Y.
    • Journal Title

      Epileptic Disord.

      Volume: 13 Pages: 340-344

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Therapy for hyperthermia-induced seizures in Scn1a mutant rats.2011

    • Author(s)
      Hayashi K, Ueshima S, Ouchida M, Mashimo T, Nishiki T, Sendo T, Serikawa T, Matsui H, Ohmori I
    • Journal Title

      Epilepsia.

      Volume: 52 Pages: 1010-1017

    • NAID

      130004505757

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 自閉症の病態生理とモデル動物を用いた最新研究2012

    • Author(s)
      大守伊織
    • Organizer
      旭川荘療育センター児童院医局セミナー
    • Place of Presentation
      岡山
    • Year and Date
      2012-04-10
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Pathophysiology and treatment in a rat model of GEFS+2012

    • Author(s)
      Ohmori I
    • Organizer
      Epilepsy Forum in Okayama
    • Place of Presentation
      岡山
    • Year and Date
      2012-02-20
    • Related Report
      2012 Final Research Report
  • [Presentation] SCN9A遺伝子変異/多型がドラベ症候群の臨床型におよぼす影響2012

    • Author(s)
      大守 伊織,Wang Haijiao,大内田 守,小林 勝弘,松井 秀樹
    • Organizer
      第46回日本てんかん学会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Scn1a遺伝子変異ラットにおける発達障害2012

    • Author(s)
      大守 伊織、大内田 守
    • Organizer
      第54回日本小児神経学総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 熱性けいれん既往患者におけるSCN9A遺伝子解析2012

    • Author(s)
      大守 伊織、小林勝弘、大内田 守
    • Organizer
      第54回日本小児神経学総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] P/Q型電位依存性カルシウムチャネル変異に伴う発達障害2012

    • Author(s)
      大内田守、大守伊織
    • Organizer
      第54回日本小児神経学総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Epilepsy-related voltage-gated calcium channel variants Cav2.1 shows a gain-of-function biophysical property.2012

    • Author(s)
      Ohmori I, Ouchida M, Kobayashi K, Michiue H, Nishiki T, Matsui H
    • Organizer
      第89回日本生理学大会
    • Place of Presentation
      松本
    • Related Report
      2012 Final Research Report
  • [Presentation] てんかん関連変異型電位依存性カルシウムチャネルの電気生理特性2011

    • Author(s)
      大守 伊織、大内田 守、Haijiao Wang、北川 雄一郎、 道上 宏之、松井 秀樹
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] 代謝性および呼吸性アシドーシスはCacna1aミスセンス変異ラットの欠神発作を抑制する2011

    • Author(s)
      大内田 守、改田 祐子、大守 伊織、上原 孝、松井 秀樹
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] シルデナフィル投与によるオキシトシン分泌を介したオスマウスでの抗うつ作用には海馬におけるMAPキナーゼとCREBのリン酸化経路が関与する2011

    • Author(s)
      松崎 光博、 松下 博昭、 韓 小建、 西木 禎一、 大守 伊織、 富澤 一仁、 松井 秀樹
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] シナプトタグミン 1のSNARE複合体からのCa2+依存性解離2011

    • Author(s)
      鈴木 孝一朗、 増本 年男、 大守 伊織、 道上 宏之、 西木 禎一、 松井 秀樹
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] 急性脳症における遺伝性けいれん素因とSCN1A遺伝子変異2011

    • Author(s)
      大守伊織、小林勝弘、大内田守、奥村彰久、前垣義弘、西山逸子、大塚頌子
    • Organizer
      第53回日本小児神経学総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] Scn1a遺伝子変異による熱性けいれんの二酸化炭素吸入療法2011

    • Author(s)
      大守伊織、大内田守、Wang Haijiao、林桂一郎、松井秀樹
    • Organizer
      第45回日本てんかん学会
    • Place of Presentation
      新潟
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://seiri1.med.okayama-u.ac.jp/

    • Related Report
      2012 Final Research Report
  • [Remarks] 岡山大学大学院医歯薬学総合研究科 細胞生理学

    • URL

      http://seiri1.med.okayama-u.ac.jp/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://seiri1.med.okayama-u.ac.jp/

    • Related Report
      2011 Research-status Report
  • [Patent(Industrial Property Rights)] Dravet 症候群の発症可能性の判定方法およびその利用2011

    • Inventor(s)
      大守伊織, 大内田守
    • Industrial Property Rights Holder
      岡山大学
    • Filing Date
      2011-01-27
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] てんかん波を伴う疾患治療剤2011

    • Inventor(s)
      大内田守, 大守伊織, 改田祐子
    • Industrial Property Rights Holder
      岡山大学
    • Filing Date
      2011-07-12
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] てんかん波を伴う疾患治療剤2011

    • Inventor(s)
      大内田守、大守伊織、改田祐子
    • Industrial Property Rights Holder
      岡山大学
    • Filing Date
      2011
    • Related Report
      2011 Research-status Report
    • Overseas

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Published: 2011-08-05   Modified: 2019-07-29  

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