New approaches of treating developmental disorders in channelopathy
Project/Area Number |
23659522
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Pediatrics
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Research Institution | Okayama University |
Principal Investigator |
OHMORI Iori 岡山大学, 大学院・医歯薬学総合研究科, 助教 (20403488)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 発達障害 / チャネル病 / 神経伝達物質 / SCN1A遺伝子 / CACNA1A遺伝子 / チャネル異常 |
Research Abstract |
Neurodevelopmental disorders includes mental retardation, autism spectrum disorder, learning disability, and attention deficit hyperactivity disorder. Molecules that modulate synaptic homeostasis are considered to be important substrates of pathogenesis in these disorders. This project reveals that dysfunction of neuronal channels also leads to neurodevelopmental disorders. These neuropsychiatric phenotypes are not caused by secondary effects of epileptic seizures or antiepileptic drugs.
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Report
(3 results)
Research Products
(36 results)
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[Journal Article] Acute encephalopathy in children with Dravet syndrome.2012
Author(s)
Okumura A, Uematsu M, Imataka G, Tanaka M, Okanishi T, Kubota T, Sudo A, Tohyama J, Tsuji M, Ohmori I, Naiki M, Hiraiwa-Sofue A, Sato H, Saitoh S, Shimizu T.
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Journal Title
Epilepsia
Volume: 53
Issue: 1
Pages: 79-86
DOI
Related Report
Peer Reviewed
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[Journal Article] Acute Encephalopathy in Children with Dravet Syndrome2011
Author(s)
Okumura A, Uematsu M, Imataka G, Tanaka M, Okanishi T, Kubota T, Sudo A, Tohyama J, Tsuji M, Ohmori I, Naiki M, Hiraiwa-Sofue A, Sato H, Saitoh S, Shimizu T.
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Journal Title
Epilepsia
Volume: 53
Pages: 79-86
Related Report
Peer Reviewed
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