| Project/Area Number |
23659523
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
MORISHIMA Tsuneo 岡山大学, 大学院・医歯薬学総合研究科, 教授 (90157892)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TSUKAHARA Hirokazu 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (90207340)
YAMASHITA Nobuko 岡山大学, 大学院・医歯薬学総合研究科, 助教 (40379798)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | インフルエンザ / 脳症 / 多臓器不全 / 肺炎 / H5N1 / 新型インフルエンザ / サイトカイン / ケモカイン / チオレドキシン / 酸化ストレス |
|---|
| Research Abstract |
The pathogenesis of highly pathogenic avian influenza H5N1 in humans has been closelsimilar to those of severe pneumonia and influenza-associated encephalopathy witcytokine storm. Using microarray assay we have analyzed gene expression in the acute phasof 2009pdm infection. Interestingly, gene expression profiles were different betweepneumonia patients and patients with CNS manifestations. Particularly, gene expressiorelated to ROD has been highly activated. Using mouse model, we have shown that thioredoxin-1(TRX) could suppress the oxidativstress and inflammatory changes resulting better outcome in pneumonia with influenzvirus infections. Taking together, anti-oxidant stress agents such as TRX could play an important rolin the severe pneumonia/ARD with H5N1 infections.
|
