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Development of new control methods for Serratia infections using the lytic enzyme of bacteriophage

Research Project

Project/Area Number 23659524
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionKochi University

Principal Investigator

MATSUSHITA KENSHI  高知大学, 教育研究部医療学系, 講師 (20332835)

Co-Investigator(Kenkyū-buntansha) MATSUZAKI Shigenobu  高知大学, 教育研究部医療学系, 准教授 (00190439)
DAIBATA Masanori  高知大学, 教育研究部医療学系, 教授 (50263976)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsバクテリオファージ / 溶菌酵素 / ファージ療法 / セラチア菌 / グラム陰性菌 / 外膜
Research Abstract

Development of multidrug-resistance makes medical treatment to Serratia marscecens infections by antibiotics difficult. We examined a possible control method to S. marscecens infections using the lytic enzyme of bacteriophage (phage). The complete genome sequences of two Serratia phages KSP90 and KSP100, isolated by us, were analyzed. The genes with lytic enzyme domains, however, were not specified. Alternatively, the lytic enzyme of phage ETA was fused with the possible outer membrane penetration domain of the Bacillus phage lytic enzyme. Examination of bacteriolytic activity of the fused protein to S. marscecens is advanced.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (69 results)

All 2014 2013 2012 2011 Other

All Journal Article (24 results) (of which Peer Reviewed: 21 results,  Open Access: 1 results) Presentation (39 results) (of which Invited: 1 results) Book (2 results) Patent(Industrial Property Rights) (4 results)

  • [Journal Article] Experimental phage therapy against lethal lung-derived septicemia caused by Staphylococcus aureus in mice.2014

    • Author(s)
      Takemura-Uchiyama I, Uchiyama J, Osanai M, Morimoto N, Asagiri T, Ujihara T, Daibata M, Sugiura T, Matsuzaki S.
    • Journal Title

      Microbes Infect.

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intragenus generalized transduction in Staphylococcus spp. by a novel giant phage.2014

    • Author(s)
      Uchiyama J, Takemura-Uchiyama I, Sakaguchi Y, Gamoh K, Kato SI, Daibata M, Ujihara T, Misawa N, Matsuzaki S
    • Journal Title

      ISME J.

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In silico analysis of AHJD-like viruses, Staphylococcus aureus phages S24-1 and S13', and study of phage S24-1 adsorption.2014

    • Author(s)
      Uchiyama J, Takemura-Uchiyama I, Kato S, Sato M, Ujihara T, Matsui H, Hanaki H, Daibata M, Matsuzaki S.
    • Journal Title

      Microbiologyopen.

      Volume: 3 Issue: 2 Pages: 257-270

    • DOI

      10.1002/mbo3.166

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synergistic bacteriolysis by bacteriophage EF24C endolysin ORF9 and lantibiotic nisin and its appl ication to pulsed-field gel electro phoreic analysis of Enterococcus fa ecalis2013

    • Author(s)
      Takemura-Uchiyama I, Uchiyama J, Sa toh M, Uhihara T, Daibata M, Matsuzaki S
    • Journal Title

      Annals of Microbiology

      Volume: 63(3) Pages: 1209-1211

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluating eff icacy of bacteriophage therapy again st Staphylococcus aureus infections using a silkworm larval infection mo del2013

    • Author(s)
      Takemura-Uchiyama I, Uchiyama J, Kato S, Inoue T, Ujihara T, Ohara N, Da ibata M, Matsuzaki S
    • Journal Title

      FEMS Microbiol Lett

      Volume: 347(1) Pages: 52-60

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characteriz ation of Helicobacter pylori bacteri ophage KHP302013

    • Author(s)
      Uchiyama J, Takeuchi H, Kato S, Gamoh K, Takemura-Uchiyama I, Ujihara T, Daibata M, Matsuzaki S
    • Journal Title

      Appl. Environ. Microbiol

      Volume: 79(10)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] バクテリオファージ尾部吸着分子を利用した細菌検出法2013

    • Author(s)
      内山淳平、内山(竹村)伊代、渡辺茂、大畑雅典、松崎茂展
    • Journal Title

      バイオインダストリー

      Volume: 30(2) Pages: 47-53

    • Related Report
      2013 Final Research Report
  • [Journal Article] ynergistic bacteriolysis by bacteriophage EF24C endolysin ORF9 and lantibiotic nisin and its application to pulsed-field gel electrophoreic analysis of Enterococcus faecalis2013

    • Author(s)
      Takemura-Uchiyama I, Uchiyama J, Satoh M, Uhihara T, Daibata M, Matsuzaki S
    • Journal Title

      Annals of Microbiology

      Volume: 63 Pages: 1209-1211

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluating efficacy of bacteriophage therapy against Staphylococcus aureus infections using a silkworm larval infection model.2013

    • Author(s)
      Takemura-Uchiyama I, Uchiyama J, Kato S, Inoue T, Ujihara T, Ohara N, Daibata M, Matsuzaki S.
    • Journal Title

      FEMS Microbiol Lett.

      Volume: 347 Issue: 1 Pages: 52-60

    • DOI

      10.1111/1574-6968.12220

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of Helicobacter pylori bacteriophage KHP30.2013

    • Author(s)
      Uchiyama J, Takeuchi H, Kato S, Gamoh K, Takemura-Uchiyama I, Ujihara T, Daibata M, Matsuzaki S.
    • Journal Title

      Appl Environ Microbiol.

      Volume: 79 Issue: 10 Pages: 3176-3184

    • DOI

      10.1128/aem.03530-12

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of Helicobacter pylori Bacteriophage KHP302013

    • Author(s)
      Uchiyama J, Takeuchi H, Kato S, Gamoh K, Takemura-Uchiyama I, Ujihara T, Daibata M, Matsuzaki S.
    • Journal Title

      Appl Environ Microbiol.

      Volume: 79 Pages: 3176-3184

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] バクテリオファージ尾部吸着分子を利用した細菌検出法2013

    • Author(s)
      内山淳平、内山(竹村)伊代、渡辺茂、大畑雅典、松崎茂展
    • Journal Title

      バイオインダストリ-

      Volume: 30 Pages: 47-53

    • Related Report
      2012 Research-status Report
  • [Journal Article] Pseudomonas aeruginosa keratitis in mice : effects of topical bacteriophage KPP12 administration2012

    • Author(s)
      Fukuda K, Ishida W, Uchiyama J, Rashel M, Kato S, Morita T, Muraoka A, Sumi T, Matsuzaki S, Daibata M, Fukus hima A
    • Journal Title

      PLoS One

      Volume: 7(10)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analys is of deoxynucleosides in bacteriophages ϕEF24C and K and the frequency of a specific restriction site in the genomes of members of the bacteriophage subfamily Spounavirinae2012

    • Author(s)
      Uchiyama J, Maeda Y, Takemura I, Gamoh K, Matsuzaki S, Daibata M
    • Journal Title

      Arch Virol

      Volume: 157(8) Pages: 1587-92

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Complete genome sequences of two Helicobacter pylori bacteriophages isolated from Japanese patients2012

    • Author(s)
      Uchiyama J, Takeuchi H, Kato S, Takemura-Uchiyama I, Ujihara T, Daibata M, Matsuzaki S
    • Journal Title

      J Virol

      Volume: 86(20) Pages: 11400-1

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic characterization of Pseudomonas aeruginosa bacteriophage KPP102012

    • Author(s)
      Uchiyama J, Rashel M, Takemura I, Kato S, Ujihara T, Muraoka A, Matsuzaki S, Daibata M
    • Journal Title

      Arch Virol

      Volume: 157(4) Pages: 733-8

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pseudomonas aeruginosa keratitis in mice: effects of topical bacteriophage KPP12 administration.2012

    • Author(s)
      Fukuda K, Ishida W, Uchiyama J, Rashel M, Kato S, Morita T, Muraoka A, Sumi T, Matsuzaki S, Daibata M, Fukushima A
    • Journal Title

      PLoS One

      Volume: 7

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Complete genome sequences of two Helicobacter pylori bacteriophages isolated from Japanese patients.2012

    • Author(s)
      Uchiyama J, Takeuchi H, Kato S, Takemura-Uchiyama I, Ujihara T, Daibata M, Matsuzaki S.
    • Journal Title

      J Virol.

      Volume: 86 Pages: 11400-11401

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Analysis of deoxynucleosides in bacteriophages ϕEF24C and K and the frequency of a specific restriction site in the genomes of members of the bacteriophage subfamily Spounavirinae.2012

    • Author(s)
      Uchiyama J, Maeda Y, Takemura I, Gamoh K, Matsuzaki S, Daibata M.
    • Journal Title

      Arch Virol.

      Volume: 157 Pages: 1587-1592

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genetic characterization of Pseudomonas aeruginosa bacteriophage KPP10.2012

    • Author(s)
      Uchiyama J, Rashel M, Takemura I, Kato S, Ujihara T, Muraoka A, Matsuzaki S, Daibata M.
    • Journal Title

      Arch Virol.

      Volume: 157 Pages: 733-738

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Promoter methylation of the bone merphorgenetic protein 6 gene in multiple myeloma2012

    • Author(s)
      Yumiko Hashida, Yuiko Nemoto, Masayuki Imajoh, Masanao Murakami, Ayuko Taniguchi, Naoki Komatsu, Akihito Yokoyama, Masanori Daibata
    • Journal Title

      Oncol.Rep.

      Volume: 27 Pages: 825-830

    • DOI

      10.3892/or.2011.1548

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Improved adsorption of an Enterococcus faecalis bacteriophage ΦEF24C with a spontaneous point mutation2011

    • Author(s)
      Uchiyama J, Takemura I, Satoh M, Kato S, Ujihara T, Akechi K, Matsuzaki S, Daibata M
    • Journal Title

      PLoS One

      Volume: 6(10)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] バクテリオファージ療法研究の現状と展望2011

    • Author(s)
      松崎茂展、内山淳平、竹村伊代、大畑雅典
    • Journal Title

      日本医事新報

      Volume: 4551 Pages: 48-49

    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Journal Article] Improved adsorption of an Enterococcus faecalis bacteriophage ΦEF24C with a spontaneous point mutation.2011

    • Author(s)
      Uchiyama J, Takemura I, Satoh M, Kato S, Ujihara T, Akechi K, Matsuzaki S, Daibata M.
    • Journal Title

      PLoS One.

      Volume: 6(10)

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Estimation of Helicobacter pylori phage ecology2014

    • Author(s)
      Matsuzaki S, Uchiyama J, Takeuchi H, Takemura-Uchiyama I, Sakaguchi Y, Ujihara T, Daibata M
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2013 Final Research Report
  • [Presentation] 緑膿菌ファージKPP22 吸着能変異ファージの解析2014

    • Author(s)
      宮田怜奈、内山淳平、山口琴絵、重久立、内山伊代、氏原隆子、大畑雅典、松崎茂展
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2013 Final Research Report
  • [Presentation] Phage therapy experiment against staphylococcal lung-derived septic mouse model2014

    • Author(s)
      Takemura-Uchiyama I, Uchiyama J, Sakaguchi Y, Ujihara T, Daibata M, Matsuzaki S
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      タワーホール船堀 (東京)
    • Related Report
      2013 Final Research Report
  • [Presentation] 緑膿菌ファージKPP22吸着能変異ファージの解析2014

    • Author(s)
      宮田怜奈、内山淳平、山口琴絵、重久 立、内山伊代、氏原隆子、大畑雅典、松 崎茂展
    • Organizer
      第87回日本細菌学会 総会
    • Place of Presentation
      東京都 タワーホール船堀
    • Related Report
      2013 Annual Research Report
  • [Presentation] 黄色ブドウ球 菌性肺由来敗血症マウスモデルにおけるファージ療法の検討2014

    • Author(s)
      内山伊代、内山淳平、阪口義彦、氏原隆子、大畑雅典、松崎茂展
    • Organizer
      第87回日本細菌学 会総会
    • Place of Presentation
      東京都 タワーホール船堀
    • Related Report
      2013 Annual Research Report
  • [Presentation] 緑膿菌ファージKPP21、KPP22、KPP23、KPP25の網羅的構造タンパク質解析2014

    • Author(s)
      重久 立、内山淳平、宮田怜奈、山口琴絵、内山伊代、氏原隆子、大畑雅典、松 崎茂展
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      東京都 タワーホール船堀
    • Related Report
      2013 Annual Research Report
  • [Presentation] 新規ファージ S6の分離とブドウ球菌における普遍形質導入の検討2014

    • Author(s)
      内山淳平、内山伊代、阪口義彦、三澤尚明、大畑雅典、松崎茂展
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      東京都 タワーホール船堀
    • Related Report
      2013 Annual Research Report
  • [Presentation] Helicobacter pylori バクテリオファージKHP30 およびその遊離宿主菌株の解析2013

    • Author(s)
      松崎茂展,内山淳平,竹内啓晃,内山(竹村)伊代,氏原隆子,大畑雅典
    • Organizer
      第66回日本細菌学会中国・四国支部総会
    • Place of Presentation
      広島国際大学(広島県呉市)
    • Related Report
      2013 Final Research Report
  • [Presentation] Helicobacter pylori バクテリオファージKHP30 およびその遊離宿主菌株の解析2013

    • Author(s)
      松崎茂展, 内山淳平,竹内啓晃,内山(竹村)伊代,氏原隆子,大畑雅典
    • Organizer
      第66回日本細菌学会中国・四国支部総会
    • Place of Presentation
      広島県 広島国際大学呉キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] 黄色ブドウ球菌性肺感染症に対するファージ療法の可能性の検討2013

    • Author(s)
      松崎茂展,内山淳平,内山(竹村)伊代,阪口義彦,加藤伸一郎,氏原隆子、大 畑雅典
    • Organizer
      第58回 ブドウ球菌研究会
    • Place of Presentation
      東京都 東京薬科大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] A Novel type of spherical bacteriophge, Helicobacter pylori bacteriophage KHP302013

    • Author(s)
      Uchiyama J, Takeuchi H, Sakagucvhi Y, Gamo K, Kato S, Takemura-Uchiyama I, Ujihara T, Daibata M, Matsuzaki S
    • Organizer
      5Th Congress of Europea Microbiologists (FEMS 2013)
    • Place of Presentation
      Leipzig, Germany
    • Related Report
      2013 Annual Research Report
  • [Presentation] Bacterial detection system for Staphylococcus aureus based on bacteriophage tail adsorption protein2013

    • Author(s)
      Uchiyama J, Uchiyama-Takemura I, Watanabe S, Sakaguchi Y, Daibata M, Matsuzaki M
    • Organizer
      28th International Congress of Chemotherapy and Infection
    • Place of Presentation
      Yokohama (Japan)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ピロリ菌バクテリオファージ(フアージ)KHP30の形態とゲノム解析2013

    • Author(s)
      内山淳平、竹内啓晃、阪口義彦、氏原隆子、内山伊代、大畑雅典、松崎茂展
    • Organizer
      第86回日本細菌学会総会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2012 Research-status Report
  • [Presentation] 黄色ブドウ球菌バクテリオファージ尾部吸着タンパク質と細菌側レセプターの同定2012

    • Author(s)
      内山淳平、内山伊代、宮田怜奈、山口琴絵、重久立、氏原隆子、大畑雅典、松崎茂展
    • Organizer
      第65回日本細菌学会中国・四国支部総会
    • Place of Presentation
      徳島大学(徳島)
    • Related Report
      2013 Final Research Report
  • [Presentation] 難治性黄色ブドウ球菌感染症に対するバクテリオファージ療法の開発 : 治療用ファージバンクの構築2012

    • Author(s)
      内山淳平,竹村伊代,氏原隆子,松崎茂展,大畑雅典
    • Organizer
      第86回日本感染症学会総会
    • Place of Presentation
      長崎ブリックホール他(長崎)
    • Related Report
      2013 Final Research Report
  • [Presentation] 胆汁うっ滞が遷延し肝生検で肝内胆管減少症と診断された超低出生体重児の1例2012

    • Author(s)
      荒木まり子, 高杉尚志, 三浦紀子, 松下憲司, 藤枝幹也, 脇口 宏, 中尾紀恵, 河本浩二, 惠谷ゆり, 位田 忍
    • Organizer
      第39回日本小児栄養消化器肝臓学会
    • Place of Presentation
      梅田スカイビルタワーウエスト(大阪)
    • Related Report
      2013 Final Research Report
  • [Presentation] 高度な高ビリルビン血症を呈さなかったが後に核黄疸と診断された極低出生体重児の1例(ワークショップ「古くて新しい問題、核黄疸 -UB(アンバウンドビリルビン)を中心に」)2012

    • Author(s)
      松下憲司,三浦紀子,細川卓利,脇口宏,深谷孝夫
    • Organizer
      第48回日本周産期・新生児医学会学術集会
    • Place of Presentation
      大宮ソニックシティ(埼玉)
    • Related Report
      2013 Final Research Report
  • [Presentation] ファージリガンド分子を利用した細菌検査法の開発2012

    • Author(s)
      内山淳平,竹村伊代,氏原隆子,松崎茂展,大畑雅典
    • Organizer
      第86回日本感染症学会総会
    • Place of Presentation
      長崎ブリックホール他(長崎)
    • Related Report
      2013 Final Research Report
  • [Presentation] X-linked Myotubular myopathy の一例2012

    • Author(s)
      大石 拓, 高杉尚志, 三浦紀子, 荒木まり子, 満田直美, 佐藤哲也, 松下憲司, 久川浩章, 藤枝幹也, 脇口 宏
    • Organizer
      第115回日本小児科学会
    • Place of Presentation
      福岡国際会議場等(福岡)
    • Related Report
      2013 Final Research Report
  • [Presentation] Improved adsorption of an Enterococcus faecalis bacteriophage phiEF24C with a point mutation2012

    • Author(s)
      Uchiyama J, Takemura I, Ujihara T, Matsuzaki S, Daibata M
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎ブリックホール他(長崎)
    • Related Report
      2013 Final Research Report
  • [Presentation] 緑膿菌臨床分離株に対するバクテリオファージKPP12 の溶菌効果の検討2012

    • Author(s)
      福田 憲,内山淳平,森田珠恵,石田わか,角環,松崎茂展,大畑雅典,福島敦樹
    • Organizer
      角膜カンファランス
    • Place of Presentation
      ホテルニューオータニ(東京)
    • Related Report
      2013 Final Research Report
  • [Presentation] 黄色ブドウ球菌ファージの尾部リガンドタンパク質を利用した細菌検出法の開発2012

    • Author(s)
      内山伊代,内山淳平,松崎茂展,杉浦哲朗,大畑雅典
    • Organizer
      第8回合同地方会(第57回日本臨床検査医学会中国・四国支部総会,第152回日本臨床化学会中国支部例会・総会,第22回日本臨床化学会四国支部例会・総会)
    • Place of Presentation
      岡山大学(岡山)
    • Related Report
      2013 Final Research Report
  • [Presentation] 新規緑膿菌バクテリオファージの分離と性状解析2012

    • Author(s)
      山口琴絵, 宮田怜奈, 重久立, 内山淳平, 内山伊代, 氏原隆子, 大畑雅典, 松崎茂展
    • Organizer
      第65回日本細菌学会中国四国支部総会
    • Place of Presentation
      徳島大学長井記念ホール(徳島)
    • Related Report
      2012 Research-status Report
  • [Presentation] 緑膿菌感染症に対するバクテリオファージ療法系の構築2012

    • Author(s)
      宮田怜奈、山口琴絵、重久立、内山淳平、内山伊代、氏原隆子、大畑雅典、松崎茂展
    • Organizer
      第65回日本細菌学会中国四国支部総会
    • Place of Presentation
      徳島大学長井記念ホール(徳島)
    • Related Report
      2012 Research-status Report
  • [Presentation] ピロリ菌バクテリオファージの分離・解析2012

    • Author(s)
      内山淳平,竹内啓晃,加藤伸一郎,阪口義彦、蒲生啓司、氏原隆子、内山伊代、大畑雅典、松崎茂展
    • Organizer
      第4回ファージ研究会
    • Place of Presentation
      群馬大学刀城会館(群馬)
    • Related Report
      2012 Research-status Report
  • [Presentation] バクテリオファージの尾部リガンド分子を利用する細菌同定法2012

    • Author(s)
      松崎茂展、内山淳平、内山(竹村)伊代、大畑雅典
    • Organizer
      国際医薬品原料・中間体展(招待講演)
    • Place of Presentation
      東京(東京ビックサイト)
    • Related Report
      2011 Research-status Report
  • [Presentation] Improved adsorption of an Enterococcus faecalis bacteriophage phiEF24C with a point mutation2012

    • Author(s)
      Jumpei Uchiyama, Iyo Takemura, Takako Ujihara, Shigenobu Matsuzaki, Masanori Daibata
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎市(長崎ブリックホール)
    • Related Report
      2011 Research-status Report
  • [Presentation] 黄色ブドウ球菌ファージの尾部リガンドタンパク質を利用した細菌検出法の開発2012

    • Author(s)
      内山伊代,内山淳平,松崎茂展,杉浦哲朗,大畑雅典
    • Organizer
      第8回合同地方会(第57回日本臨床検査医学会中国・四国支部総会,第152回日本臨床化学会中国支部例会・総会,第22回日本臨床化学会四国支部例会・総会
    • Place of Presentation
      岡山市(岡山大学医学部)
    • Related Report
      2011 Research-status Report
  • [Presentation] 緑膿菌臨床分離株に対するバクテリオファージKPP12の溶菌効果の検討2012

    • Author(s)
      福田 憲,内山淳平,森田珠恵,石田わか,角 環,松崎茂展,大畑雅典,福島敦樹
    • Organizer
      角膜カンファランス2012
    • Place of Presentation
      東京都(ホテルニューオータニ)
    • Related Report
      2011 Research-status Report
  • [Presentation] Young-Simpson 症候群が疑われる1例2011

    • Author(s)
      満田直美, 細川卓利, 荒木まり子, 松下憲司, 高杉尚志, 藤枝幹也, 脇口宏
    • Organizer
      第53回日本小児神経学会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2013 Final Research Report
  • [Presentation] 多血症、DIC、消化管出血後に消化管アレルギー(下部消化器症状型)を合併した双胎第1子例2011

    • Author(s)
      松下憲司,荒木まり子,高杉尚志,山本雅樹,大石 拓,藤枝幹也 ,脇口 宏
    • Organizer
      第23回四国小児アレルギー研究会
    • Place of Presentation
      高知城ホール(高知)
    • Related Report
      2013 Final Research Report
  • [Presentation] バクテリオファージによるマウス緑膿菌角膜炎の抑制効果2011

    • Author(s)
      福田憲,石田わか,角環,森田珠恵,内山淳平,松崎茂展,大畑雅典,福島敦樹
    • Organizer
      第48回日本眼感染症学会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Related Report
      2013 Final Research Report
  • [Presentation] Improved adsorption of Enterococcus faecalis bacteriophage φEF24C caused by a point mutation in a tail fiber gene.2011

    • Author(s)
      Uchiyama J, Takemura I, Satoh M, Kato S, Ujihara T, Akechi K, Matsuzaki S, Daibata M.
    • Organizer
      International Congress of Virology.
    • Place of Presentation
      Sapporo Convention Center
    • Related Report
      2011 Research-status Report
  • [Presentation] Identification of a tail adsorption protein by comparative genomic analysis of Staphylococcus aureus bacteriophages S13’and S24-1.2011

    • Author(s)
      Takemura I, Uchiyama J, Satoh M, Kato S, Ujihara T, Akechi K, Matsuzaki S, Daibata M.
    • Organizer
      International Congress of Virology.
    • Place of Presentation
      Sapporo Convention Center
    • Related Report
      2011 Research-status Report
  • [Presentation] ファージKPP10 のゲノムDNA 解析2011

    • Author(s)
      内山淳平,竹村伊代,氏原隆子,邑岡麻子,松崎茂展,大畑雅典
    • Organizer
      第64回日本細菌学会中国・四国支部総会
    • Place of Presentation
      岡山市(岡山大学津島キャンパス)
    • Related Report
      2011 Research-status Report
  • [Presentation] 黄色ブドウ球菌ファージS13’ および S24-1ゲノム比較による尾部吸着タンパク質の同定と解析2011

    • Author(s)
      内山淳平,竹村伊代,佐藤美帆,加藤伸一郎,氏原隆子,松崎茂展,大畑雅典
    • Organizer
      第56回日本ブドウ球菌研究会
    • Place of Presentation
      高知市(高知市総合安心センター)
    • Related Report
      2011 Research-status Report
  • [Presentation] 感染効率が改善された腸球菌バクテリオファージφEF24C変異体の解析2011

    • Author(s)
      内山淳平,竹村伊代,佐藤美帆,加藤伸一郎,氏原隆子,明智和愛,松崎茂展,大畑雅典
    • Organizer
      第5回細菌学・若手コロッセウム
    • Place of Presentation
      高知市(桂浜荘)
    • Related Report
      2011 Research-status Report
  • [Presentation] バクテリオファージによるマウス緑膿菌角膜炎の抑制効果2011

    • Author(s)
      福田 憲,石田わか,角 環,森田珠恵,内山淳平,松崎茂展,大畑雅典,福島敦樹
    • Organizer
      第48回日本眼感染症学会
    • Place of Presentation
      京都市(国立京都国際会館)
    • Related Report
      2011 Research-status Report
  • [Presentation] バクテリオファージ研究の現状と展望

    • Author(s)
      松崎茂展、内山淳平、内山伊代、大畑雅典
    • Organizer
      第4回愛媛微生物学ネットワークフォーラム
    • Place of Presentation
      愛媛県 愛媛大学総合研究棟
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] Chapter10. Phage therapy : experiments using animal infection models. Phage The rapy. Current Research and Applications. Editors: Jan Borysowski, Rysz ard Międzybrodzki, Andrzej Górski2014

    • Author(s)
      Matsuzaki S, Uchiyama J, Takemura-Uchiyama I, and Daibata M
    • Total Pages
      378
    • Publisher
      Caister Academic Press
    • Related Report
      2013 Final Research Report
  • [Book] Phage Therapy. Current Research and Applications.2014

    • Author(s)
      Matsuzaki S, Uchiyama J, Takemura-Uchiyama I, and Daibata M
    • Total Pages
      318
    • Publisher
      Caister Academic Press
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 黄色ブドウ球菌を検出する方法、黄色ブドウ球菌測定用メンブレン及び黄色ブドウ球菌測定用キット2014

    • Inventor(s)
      内山淳平、内山伊代、花木秀明、松井秀仁、大畑雅典、松崎茂展
    • Industrial Property Rights Holder
      国立大学法人高知大学学校法人北里研究所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-046922
    • Filing Date
      2014-03-10
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 黄色ブドウ球菌を検出する方法、黄色ブドウ球菌測定用メンブレン及び黄 色ブドウ球菌測定用キット2014

    • Inventor(s)
      内山淳平、市山伊代、花木秀明、松井秀仁、大畑雅典、松崎茂展
    • Industrial Property Rights Holder
      学校法人北里研究所、国立大学法人高知大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-046922
    • Filing Date
      2014-03-10
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 黄色ブドウ球細菌に結合するタンパク質及びそのタンパク質を利用した黄色ブドウ球菌の測定方法2012

    • Inventor(s)
      大畑雅典、松崎茂展 内山淳平、竹村伊代
    • Industrial Property Rights Holder
      国立大学法人高知大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-160613
    • Filing Date
      2012-07-19
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 黄色ブドウ球細菌に結合するタンパク質及びそのタンパク質を利用した黄色ブドウ球細菌の測定方法2011

    • Inventor(s)
      大畑雅典、松崎茂展、内山淳平、竹村伊代
    • Industrial Property Rights Holder
      国立大学法人高知大学
    • Industrial Property Number
      2011-192996
    • Filing Date
      2011
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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