| Project/Area Number |
23659532
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Institute for Developmental Research, Aichi Human Service Center |
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Principal Investigator |
NAGATA Koh-ichi 愛知県心身障害者コロニー発達障害研究所, 神経制御学部, 部長 (50252143)
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| Co-Investigator(Renkei-kenkyūsha) |
INAGUMA Yutaka 愛知県心身障害者コロニー発達障害研究所, 神経制御学部, 主任研究員 (10250250)
ITO Hidenori 愛知県心身障害者コロニー発達障害研究所, 神経制御学部, 主任研究員 (40311443)
SHINODA Tomoyasu 名古屋大学, 医学部, 助教 (80505652)
NISHIMURA Yoshiaki 同志社大学, 脳科学研究科, 助教 (50508603)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 小児神経学 / 知的障害 / 神経細胞 / SIL1 / 子宮内胎仔脳遺伝子導入 / 大脳皮質 / 発達障害 / 神経細胞移動 / マリネスコ・シェーグレン症候群 |
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| Research Abstract |
A2BP1 is implicated in a variety of neurological and developmental disorders. We here prepared a specific antibody against A2BP1 and did protein expression and localization analyses in rodent brain tissues. A2BP1 was expressed in developmental stage-dependent manners in the brain. In cortical neurons, A2BP1 was accumulated mainly in the nucleus and diffusely distributed in the cell body and dendrites. In rat hippocampal neurons, while A2BP1 was found in a punctate distribution adjacent to synapses. Knockdown of A2BP1 caused abnormal neuronal migration during corticogenesis. We did similar analyses as for a polarity-related protein, Lin7, and found the importance of Lin7 in corticogenesis.
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