| Project/Area Number |
23659535
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Embryonic/Neonatal medicine
|
|---|
| Research Institution | Hamamatsu University School of Medicine |
|---|
Principal Investigator |
FUKUDA Atsuo 浜松医科大学, 医学部, 教授 (50254272)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
INOUE Koichi 浜松医科大学, 医学部, 准教授 (80345818)
EGAWA Kiyoshi 浜松医科大学, 医学部, 特任研究員 (40450829)
HATA Kenichiro 国立成育医療研究センター, 部長 (60360335)
|
|---|
| Project Period (FY) |
2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
|
|---|
| Keywords | クロライドホメオスタシス / 皮質板細胞 / 大脳皮質 / 細胞移動 / GABA / タウリン / 母体ストレス / 発達障害 |
|---|
| Research Abstract |
The most major inhibitory neurotransmitter, GABA, induces synaptic inhibition in the adult brain. In immature neurons, however,[ Cl^-]_i is high due to balance of Cl^-transporters, promoting depolarizing GABA action by efflux of Cl^-along with its electrical gradient. Thus GABA evokes excitation and/or non-synaptic tonic depolarization in immature brain. Such multimodal GABA actions during development are necessary for neurogenesis, differentiation, migration, and synaptogenesis. Therfore, perturbation of the developmental Cl^-homeodynamics may underlie fetal and neonatal brain disorders. By using various pathological model mice, we have studied how Cl^-homeodynamics work in pathogenesis of fetal and neonatal disorders of cortical development.
|
