Prenatal treatments with bone marrow-derrived stem cells for the fetal diseases

• Project/Area Number: 23659537
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Embryonic/Neonatal medicine
• Research Institution: National Research Institute for Child Health and Development
• Principal Investigator: HAYASHI Satoshi 独立行政法人国立成育医療研究センター, その他部局等, その他 (60425717)
• Co-Investigator(Kenkyū-buntansha): UMEZAWA Akihiro 独立行政法人国立成育医療研究センター, 生殖・細胞医療研究部, 部長 (70213486)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
• Keywords: 胎児医学 / 免疫寛容 / 細胞移植 / 前臨床研究 / 幹細胞 / 胎児治療 / キメラ / モデルマウス / 低侵襲

Research Abstract

In this study, we focused on a novel therapeutic approach to genetic diseases. We investigated the donor cell chimerism by implantation of hematopoietic stem cells in the disease model mice, and evaluated therapeutic effect by survival of donor cells after transplantation of bone marrow cells. We show availability of cell-based therapy on the disease model animal by demonstrating acquisition of immune tolerance.