| Project/Area Number |
23659540
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
AIZU Takayuki 弘前大学, 大学院・医学研究科, 助教 (00400135)
NAKAJIMA Koji 弘前大学, 大学院・医学研究科, 助教 (70374832)
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| Project Period (FY) |
2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | メルケル細胞癌 / 遺伝子 / トランスジェニックマウス / テトラサイクリン / タモシキフェン / 培養細胞 / 皮膚 / 皮膚細胞 / 細胞培養 |
|---|
| Research Abstract |
If we can culture all cells in the skin in vitro, it must be a potential system which can develop to any studies. In this study, we tried to add tetracycline-induced promoter and LoxP sequence which is cleaved by Cre recombinase to the vector DNA and generate a transgenic mouse with MCV-Large T gene which is induced by treatment of tetracycline and is abolished by treatment of tamoxifen.
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