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Molecular mechanism of TSLP production in keratinocytes in atopic dermatitis

Research Project

Project/Area Number 23659546
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionNagoya University

Principal Investigator

AKIYAMA Masashi  名古屋大学, 医学系研究科, 教授 (60222551)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
KeywordsTSLP / アトピー性皮膚炎 / 小胞体ストレス応答 / フィラグリン / 表皮角化細胞 / Flaky tail mouse
Research Abstract

Thymic stromal lymphopoietin (TSLP) is one of the most important chemokine for pathogenesis of atopic dermatitis (AD), which is secreted by keratinocytes. However, which kinds of stimuli induce TSLP is not unidentified well. In this study, we suggested the unfolded protein response in keratinocytes induce TSLP.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (57 results)

All 2013 2012 2011 Other

All Journal Article (30 results) (of which Peer Reviewed: 27 results) Presentation (25 results) (of which Invited: 9 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Paraneoplastic pemphigus with anti-laminin-332 autoantibodies in a patient with follicular dendritic cell sarcoma2013

    • Author(s)
      Sugiura K
    • Journal Title

      JAMA Dermatol

      Volume: 149 Issue: 1 Pages: 111-113

    • DOI

      10.1001/2013.jamadermatol.512

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low prevalence of anti-DFS70/LEDGF antibodies in patients with dermatomyositis and with other systemic autoimmune rheumatic diseases2013

    • Author(s)
      Muro Y, Sugiura K, et al.
    • Journal Title

      J Rheumatol

      Volume: 40 Issue: 1 Pages: 92-93

    • DOI

      10.3899/jrheum.121168

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Limitations of a single-point evaluation of anti-MDA5 antibody, ferritin, and IL-18 in predicting the prognosis of interstitial lung disease with anti-MDA5 antibody-positive dermatomyositis2013

    • Author(s)
      Muro Y
    • Journal Title

      Clin Rheumatol

      Volume: 32 Issue: 3 Pages: 395-398

    • DOI

      10.1007/s10067-012-2142-x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel ABCA12 splice site deletion mutation and ABCA12 mRNA analysis of pulled hair samples in harlequin ichthyosis2013

    • Author(s)
      Takeichi T, Sugiura K, et al.
    • Journal Title

      J Dermatol Sci

      Volume: 69 Issue: 3 Pages: 259-261

    • DOI

      10.1016/j.jdermsci.2012.11.004

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low prevalence of autoantibodies to CENP-H, -I, -K, -L, -M, -N, -T and -U in a Japanese cohort of anti-centromere positive samples2013

    • Author(s)
      Saito A, Muro Y, Sugiura K, et al.
    • Journal Title

      Immunopharmacol Immunotoxicol

      Volume: 35 Issue: 1 Pages: 57-63

    • DOI

      10.3109/08923973.2012.733707

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Perinatal cytomegalovirus-associated bullae in an immunocompetent infant2012

    • Author(s)
      Yasuda K, Sugiura K, et al.
    • Journal Title

      Arch Dermatol

      Volume: 148 Issue: 6 Pages: 770-772

    • DOI

      10.1001/archdermatol.2011.3258

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autoantibodies to nuclear matrix protein 2 /MJ in adult-onset dermatomyositis with severe calcinosis2012

    • Author(s)
      Sugiura K
    • Journal Title

      J Am Acad Dermatol

      Volume: 67 Issue: 4 Pages: e167-e168

    • DOI

      10.1016/j.jaad.2012.01.015

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of an ELISA for detection of autoantibodies to nuclear matrix protein 22012

    • Author(s)
      Ishikawa A
    • Journal Title

      Rheumatology (Oxford)

      Volume: 51 Issue: 7 Pages: 1181-1187

    • DOI

      10.1093/rheumatology/kes033

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Four novel ADAR1 gene mutations in patients with dyschromatosis symmetrica hereditaria2012

    • Author(s)
      Kono M, Akiyama M, Kondo T, Suzuki T, Suganuma M, Wataya-Kaneda M, Lam J, Shibaki A, Tomita Y
    • Journal Title

      J Dermatol

      Volume: 39 Issue: 9 Pages: 819-21

    • DOI

      10.1111/j.1346-8138.2011.01385.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Drug eruption due to sodium picosulfate2012

    • Author(s)
      Ishikawa A
    • Journal Title

      Eur J Dermatol

      Volume: 22 Issue: 3 Pages: 410-411

    • DOI

      10.1684/ejd.2012.1679

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical features of anti-TIF1-α antibody-positive dermatomyositis patients are closely associated with coexistent dermatomyositis-specific autoantibodies and anti-TIF1-γ or anti-Mi-2 autoantibodies2012

    • Author(s)
      Muro Y
    • Journal Title

      Rheumatology (Oxford)

      Volume: 51 Issue: 8 Pages: 1508-1513

    • DOI

      10.1093/rheumatology/kes073

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel IL36RN/IL1F5 homozygous nonsense mutation, p.Arg10X, in a Japanese patient with adult-onset generalized pustular psoriasis2012

    • Author(s)
      Sugiura K
    • Journal Title

      Br J Dermatol

      Volume: 167 Issue: 3 Pages: 699-701

    • DOI

      10.1111/j.1365-2133.2012.10953.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The β9 Loop Domain of PA-PLA(1)α Has a Crucial Role in Autosomal Recessive Woolly Hair/Hypotrichosis2012

    • Author(s)
      Shinkuma S, Inoue A, Aoki J, Nishie W, Natsuga K, Ujiie H, Nomura T, Abe R, Akiyama M, Shimizu H
    • Journal Title

      The Journal of Investigative Dermatology

      Volume: (印刷中) Issue: 8 Pages: 2093-2095

    • DOI

      10.1038/jid.2012.96

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extraordinarily large protruding accessory breast cancer in a male2012

    • Author(s)
      Yoshida Y
    • Journal Title

      J Am Acad Dermatol

      Volume: 67 Issue: 5 Pages: e230-e231

    • DOI

      10.1016/j.jaad.2012.04.034

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A group of atopic dermatitis without IgE elevation or barrier impairment shows a high Th1 frequency: Possible immunological state of the intrinsic type2012

    • Author(s)
      Kabashima-Kubo R, Nakamura M, Sakabe, J, Sigita K, Hino R, Mori T, Kobayashi M, Bito T, Kabashima K, Ogasawara K, Nomura Y, Nomura T, Akiyama M, Shimizu H, Tokura Y.
    • Journal Title

      J Dermatol Sci

      Volume: 67 Issue: 1 Pages: 37-43

    • DOI

      10.1016/j.jdermsci.2012.04.004

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Severe chilblain lupus is associated with heterozygous missense mutations of catalytic amino acids or their adjacent in the exonuclease domains of 3'-repair exonuclease 12012

    • Author(s)
      Sugiura K
    • Journal Title

      J Invest Dermatol

      Volume: 132 Issue: 12 Pages: 2855-2857

    • DOI

      10.1038/jid.2012.210

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coexistence of pustular and vegetative pyoderma gangrenosum in a patient with myelodysplastic syndrome2012

    • Author(s)
      Omiya W
    • Journal Title

      Eur J Dermatol

      Volume: 22 Issue: 5 Pages: 1659-1671

    • DOI

      10.1684/ejd.2012.1813

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Type VII collagen deficiency causesdefective tooth enamel formation due to poor differentiation of ameloblasts2012

    • Author(s)
      Umemoto H, Akiyama M, Domon T, Nomura T, Shinkuma S, Ito K, Asaka T, Sawamura D, Uitto J, Uo M, Kitagawa Y, Shimizu H
    • Journal Title

      Am J Pathol

      Volume: 181 Issue: 5 Pages: 1659-71

    • DOI

      10.1016/j.ajpath.2012.07.018

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiokeratoma of the scrotum and sublingual varices in a patient with jejunal phlebectasia2012

    • Author(s)
      Takama H
    • Journal Title

      Eur J Dermatol

      Volume: 22 Issue: 6 Pages: 818-819

    • DOI

      10.1684/ejd.2012.1868

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Haploinsufficiency for AAGAB causes clinically heterogeneous forms of punctate palmoplantar keratoderma2012

    • Author(s)
      Pohler E
    • Journal Title

      Nat Genet

      Volume: 44 Issue: 11 Pages: 1272-1276

    • DOI

      10.1038/ng.2444

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AKT has an anti-apoptotic role in ABCA12-deficient keratinocytes.2011

    • Author(s)
      Yanagi T, Akiyama M, Nishihara H, Miyamura Y, Sakai K, Tanaka S, Shimizu H.
    • Journal Title

      J Invest Dermatol

      Volume: 131 Pages: 1942-1945

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Consequences of two different amino acid substitutions at the same codon in KRT14indicate definitive roles of structural distortion in epidermolysis bullosa simplex pathogenesis2011

    • Author(s)
      Natsuga K, Nishie W, Smith BJ, Shinkuma S, Smith TA, Parry DAD, Oiso N, Kawada A, Yoneda K, Akiyama M, Shimizu H
    • Journal Title

      J Invest Dermatol

      Volume: 131 Pages: 1869-1876

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Filaggrin gene defects and the risk of developing allergic disorders2011

    • Author(s)
      Osawa R, Akiyama M, Shimizu H
    • Journal Title

      Allergol Int

      Volume: 60 Pages: 1-9

    • NAID

      10031143293

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The roles of ABCA12 in keratinocyte differentiation and lipid barrier formation in the epidermis.2011

    • Author(s)
      Akiyama M
    • Journal Title

      Dermato-Endocrinology

      Volume: 3 Pages: 107-112

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Updated molecular genetics and pathogenesis of ichthyoses2011

    • Author(s)
      Akiyama M
    • Journal Title

      Nagoya J Med Sci

      Volume: 73 Pages: 79-90

    • NAID

      120003277468

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] アトピー性皮膚炎の発症因子 フィラグリン遺伝子変異の全国調査2011

    • Author(s)
      秋山真志
    • Journal Title

      医薬の門

      Volume: 51(1) Pages: 1-7

    • Related Report
      2012 Final Research Report
  • [Journal Article] 皮膚科セミナリウム(第71回) 角化症 魚鱗癬と魚鱗癬症候群2011

    • Author(s)
      秋山真志
    • Journal Title

      日本皮膚科学会雑誌

      Volume: 124(4) Pages: 667-673

    • Related Report
      2012 Final Research Report
  • [Journal Article] アトピー性皮膚炎の病態と治療: アトピー性皮膚炎におけるフィラグリン遺伝子異常2011

    • Author(s)
      秋山真志
    • Journal Title

      Derma

      Volume: 175 Pages: 1-6

    • Related Report
      2012 Final Research Report
  • [Journal Article] Filaggrin gene defects and the risk of developing allergic disorders.2011

    • Author(s)
      Osawa R, Akiyama M, Shimizu H.
    • Journal Title

      Allergol Int

      Volume: 60 Pages: 1-9

    • NAID

      10031143293

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] LEDGF/DFS70 activates the MK2/IL6/STAT3 pathway in HaCaT.2011

    • Author(s)
      Takeichi T, Kazumitsu Sugiura K, Muro Y, Ogawa Y, Akiyama M.
    • Journal Title

      J Dermatol Sci

      Volume: 63 Pages: 203-205

    • NAID

      10030892614

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] ABC Proteins/Membrane Meso-domains/ES-iPS Cells2012

    • Author(s)
      Akiyama M
    • Organizer
      ABCA12 and harlequin ichthyosis ABC Protein and Diseases ABC2011 in Kyoto
    • Place of Presentation
      京都
    • Year and Date
      2012-11-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 角層バリア機能異常症としての角化症とフィラグリン シンポジウム「Fillagrinとアトピー性皮膚炎」2012

    • Author(s)
      秋山真志
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京都港区
    • Year and Date
      2012-11-11
    • Related Report
      2012 Final Research Report
  • [Presentation] 非免疫学因子の視点から:皮膚バリア機能との関わりについて シンポジウム「小児のアトピー性皮膚炎」2012

    • Author(s)
      秋山真志
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京都港区
    • Year and Date
      2012-11-10
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト胎生期表皮における先天性魚鱗性様紅皮症の病因蛋白、NIPAL4,CYP4F22、lipoxigenase-3の発現パターンの検討 希少難治性皮膚疾患に関する調査研究班2011

    • Author(s)
      秋山真志
    • Organizer
      平成23年第2回総会
    • Place of Presentation
      東京都中央区
    • Year and Date
      2011-12-16
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規レジストリーとコホート調査の報告 希少難治性皮膚疾患に関する調査研究班2011

    • Author(s)
      秋山真志
    • Organizer
      平成23 年第2回総会
    • Place of Presentation
      東京都中央区
    • Year and Date
      2011-12-16
    • Related Report
      2012 Final Research Report
  • [Presentation] アトピー性皮膚炎の病態と治療:皮膚バリア機能障害に着目して2011

    • Author(s)
      秋山真志
    • Organizer
      日本アレルギー学会第40回教育セミナー
    • Place of Presentation
      東京都千代田区
    • Year and Date
      2011-08-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 今、注目される遺伝性皮膚バリア障害 シンポジウム「遺伝性皮膚疾患」2011

    • Author(s)
      秋山真志
    • Organizer
      第35回日本小児皮膚科学会学術大会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-07-23
    • Related Report
      2012 Final Research Report
  • [Presentation] アトピー性皮膚炎の発症因子としての日本人フィラグリン遺伝子変異2011

    • Author(s)
      秋山真志
    • Organizer
      第41回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
    • Place of Presentation
      甲府市
    • Year and Date
      2011-07-17
    • Related Report
      2012 Final Research Report
  • [Presentation] アトピー性皮膚炎と皮膚バリア機能~今、フィラグリンが注目されている理由2011

    • Author(s)
      秋山真志
    • Organizer
      第47回中部日本小児科学会 (招待講演)
    • Place of Presentation
      名古屋市
    • Related Report
      2011 Research-status Report
  • [Presentation] アトピー性疾患の発症因子としての日本人フィラグリン遺伝子変異2011

    • Author(s)
      秋山真志
    • Organizer
      第41回日本皮膚アレルギー・接触皮膚炎学会総会学術大会(招待講演)
    • Place of Presentation
      甲府市
    • Related Report
      2011 Research-status Report
  • [Presentation] 今、注目される遺伝性皮膚バリア障害2011

    • Author(s)
      秋山真志
    • Organizer
      第35回日本小児皮膚科学会学術大会(招待講演)
    • Place of Presentation
      横浜市
    • Related Report
      2011 Research-status Report
  • [Presentation] 非免疫学的因子の視点から:皮膚バリア機能との関わりについて2011

    • Author(s)
      秋山真志
    • Organizer
      第61回日本アレルギー学会秋季学術大会(招待講演)
    • Place of Presentation
      東京都港区
    • Related Report
      2011 Research-status Report
  • [Presentation] 角層バリア機能異常症としての角化症とフィラグリン2011

    • Author(s)
      秋山真志
    • Organizer
      第61回日本アレルギー学会秋季学術大会(招待講演)
    • Place of Presentation
      東京都港区
    • Related Report
      2011 Research-status Report
  • [Presentation] 角化症診療のカッティング・エッジ 角化症の出生前診断up-to-date

    • Author(s)
      秋山真志
    • Organizer
      第111回日本皮膚科学会総会
    • Place of Presentation
      京都国際会館
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 教育講習会、わかりやすい皮膚遺伝性疾患 遺伝性角化症とアトピー性皮膚炎

    • Author(s)
      秋山真志
    • Organizer
      第111回日本皮膚科学会総会
    • Place of Presentation
      京都国際会館
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 教育講演、表皮の構造と機能

    • Author(s)
      秋山真志
    • Organizer
      第30回日本美容皮膚科学会総会、学術大会
    • Place of Presentation
      ウエスティンナゴヤキャッスルホテル
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 教育セミナー、皮膚アレルギーHot Topics アレルギー性疾患に対する皮膚角層バリア機能障害の関与を考える

    • Author(s)
      秋山真志
    • Organizer
      第62回日本アレルギー学会秋季学術大会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 皮膚バリア障害から考えるアトピー性疾患の病態と治療法

    • Author(s)
      秋山真志
    • Organizer
      平成24年度日本医師会主催生涯教育講座(皮膚科)
    • Place of Presentation
      愛知県医師会館地下講堂
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ランチプログラム、アトピー性皮膚炎のトピックス、アトピー性皮膚炎の発症とバリア機能

    • Author(s)
      秋山真志
    • Organizer
      第24回日本アレルギー学会春季臨床大会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ランチョンセミナー、アレルギー性疾患とフィラグリン遺伝子変異

    • Author(s)
      秋山真志
    • Organizer
      第63回日本皮膚科学会中部支部学術大会
    • Place of Presentation
      グランキューブ大阪
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] イブニングセミナー、アトピー性皮膚炎と皮膚バリア機能障害

    • Author(s)
      秋山真志
    • Organizer
      第63回日本皮膚科学会中部支部学術大会
    • Place of Presentation
      グランキューブ大阪
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Sweets’ seminar、Stratum corneum barrier defects and atopic disorders; tight junctions

    • Author(s)
      Akiyama M
    • Organizer
      The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      ロワジールホテル那覇
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ABCA12機能障害による先天性魚鱗癬様紅皮症の発症機序の解明と治療法の開発

    • Author(s)
      秋山真志
    • Organizer
      稀少難治性皮膚疾患に関する調査研究班 平成24年度第1回総会
    • Place of Presentation
      KKRホテル東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規レジストリーとコホート調査の現状と今後の予定

    • Author(s)
      秋山真志
    • Organizer
      稀少難治性皮膚疾患に関する調査研究班 平成24年度第1回総会
    • Place of Presentation
      KKRホテル東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規レジストリーとコホート調査の現状と今後の予定

    • Author(s)
      秋山真志
    • Organizer
      稀少難治性皮膚疾患に関する調査研究班 平成24年度第2回総会
    • Place of Presentation
      KKRホテル東京
    • Related Report
      2012 Annual Research Report
  • [Book] 今日の治療指針2011年版2011

    • Author(s)
      秋山真志
    • Total Pages
      1031
    • Publisher
      医学書院
    • Related Report
      2011 Research-status Report
  • [Remarks] 名古屋大学医学部皮膚科ホームページ

    • URL

      http://www.med.nagoya-u.ac.jp/derma/

    • Related Report
      2012 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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