Molecular mechanism of TSLP production in keratinocytes in atopic dermatitis
Project/Area Number |
23659546
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Dermatology
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Research Institution | Nagoya University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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Keywords | TSLP / アトピー性皮膚炎 / 小胞体ストレス応答 / フィラグリン / 表皮角化細胞 / Flaky tail mouse |
Research Abstract |
Thymic stromal lymphopoietin (TSLP) is one of the most important chemokine for pathogenesis of atopic dermatitis (AD), which is secreted by keratinocytes. However, which kinds of stimuli induce TSLP is not unidentified well. In this study, we suggested the unfolded protein response in keratinocytes induce TSLP.
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Report
(3 results)
Research Products
(57 results)
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[Journal Article] A group of atopic dermatitis without IgE elevation or barrier impairment shows a high Th1 frequency: Possible immunological state of the intrinsic type2012
Author(s)
Kabashima-Kubo R, Nakamura M, Sakabe, J, Sigita K, Hino R, Mori T, Kobayashi M, Bito T, Kabashima K, Ogasawara K, Nomura Y, Nomura T, Akiyama M, Shimizu H, Tokura Y.
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Journal Title
J Dermatol Sci
Volume: 67
Issue: 1
Pages: 37-43
DOI
Related Report
Peer Reviewed
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[Journal Article] Type VII collagen deficiency causesdefective tooth enamel formation due to poor differentiation of ameloblasts2012
Author(s)
Umemoto H, Akiyama M, Domon T, Nomura T, Shinkuma S, Ito K, Asaka T, Sawamura D, Uitto J, Uo M, Kitagawa Y, Shimizu H
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Journal Title
Am J Pathol
Volume: 181
Issue: 5
Pages: 1659-71
DOI
Related Report
Peer Reviewed
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[Journal Article] Consequences of two different amino acid substitutions at the same codon in KRT14indicate definitive roles of structural distortion in epidermolysis bullosa simplex pathogenesis2011
Author(s)
Natsuga K, Nishie W, Smith BJ, Shinkuma S, Smith TA, Parry DAD, Oiso N, Kawada A, Yoneda K, Akiyama M, Shimizu H
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Journal Title
J Invest Dermatol
Volume: 131
Pages: 1869-1876
Related Report
Peer Reviewed
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