Creation of keloids model mouse using collagen sponge seeded with keloids-derived mesenchymal cells
| Project/Area Number |
23659551
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Nagasaki University |
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Principal Investigator |
UTANI Atsushi 長崎大学, 医歯薬学総合研究科, 教授 (10292707)
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Fumihide 長崎大学, 大学病院, 講師 (10333519)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ケロイド / マウス / バーシカン / コラーゲン / 動物モデル |
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| Research Abstract |
Versican, one of extracellular matrices deposited in keloids lesion, excessively accumulated in collagen sponge seeded with keloids-derived mesenchymal cells (KLcells) at 1month after implanted in the subcutaneous space in nude mouse. Using this model, Il-1b directly injected into collagen-sponge inhibited the excessive deposition of versican. These findings suggest that this model is useful for developing therapeutic modality for refractory disease keloids.
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Report
(3 results)
Research Products
(13 results)
