Development of a new phototherapy based on the biological effects of wavelength

• Project/Area Number: 23659552
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Dermatology
• Research Institution: Nagoya City University
• Principal Investigator: MORITA Akimichi 名古屋市立大学, 大学院・医学研究科, 教授 (30264732)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 光線療法 / 免疫抑制 / 制御性 T 細胞 / TH17 / UVA1 / 制御性Ｔ細胞 / 制御性T細胞

Research Abstract

For the treatment of allergic and autoimmune diseases, the antigen-specific tolerance is needed for not only remission but also the cure of these diseases. In this application, we have analyzed the biological effects of UVB and UVA. Concomitantly, UVA1-LED device has been also developed. In the clinical application, PUVA and narrow-band UVB reduced the pathogenically relevant cells, TH17 and induced regulatory T cells successfully.

Research Products

• [Journal Article] NB-UVB irradiation increases filaggrin expression in a three-dimensional human skin model (2013)
  • Author(s): Torii, Kan, Motoki Nakamura, and Akimichi Morita
  • Journal Title: Journal of Dermatological Science Volume: 70 Issue: 2 Pages: 146-147
  • DOI: 10.1016/j.jdermsci.2013.02.007
• [Journal Article] Photo(chemo)therapy reduces circulating Th17 cells and restores circulating regulatory T cells in psoriasis (2013)
  • Author(s): Furuhashi T, Saito C, Torii K, Nishida E, Yamazaki S, Morita A
  • Journal Title: PLosOne Volume: 8 Issue: 1 Pages: e54895-e54895
  • DOI: 10.1371/journal.pone.0054895
  • Peer Reviewed
• [Journal Article] Monotherapy for vitiligo treatment using a 308-nm xenon-chloride excimer laser: colorimetry to assess the factor influencing the efficacy of this treatment in Asian patients (2012)
  • Author(s): Reiko Noborio, Motoki Nakamura, Misako Yoshida, Reiko Nakamura, Rieko Ooshima, Ryoji Kubo, Hiroshi Kato , Akimichi Morita
  • Journal Title: J Dermatol Volume: 39 Issue: 12 Pages: 1102-1103
  • DOI: 10.1111/j.1346-8138.2012.01633.x
• [Journal Article] Development of an Ultraviolet A1 Light Emitting Diode-based Device for Phototherapy (2012)
  • Author(s): Shunko A. Inada, Satoshi Kamiyama, Isamu Akasaki, Kan Torii, Takuya Furuhashi, Hiroshi Amano and Akimichi Morita
  • Journal Title: The open dermatology Journal Volume: 6 Pages: 13-24
  • URL: http://198.247.95.142/open/todj/articles/V006/13TODJ.pdf
• [Journal Article] Tobacco smoke is related to Th17 generation with clinical implications for psoriasis patients (2011)
  • Author(s): Kan Torii, Chiyo Saito, Takuya Furuhashi, Akiko Nishioka, Yoichi Shintani, Kana Kawashima, Hiroshi Kato, and Akimichi Morita
  • Journal Title: Exp Dermatol Volume: 20 Issue: 4 Pages: 371-373
  • DOI: 10.1111/j.1600-0625.2010.01224.x
• [Journal Article] Phototherapy reduces serum resistin levels of psoriasis patients. (2011)
  • Author(s): Kana Kawashima, Kan Torii, Takuya Furuhashi,Chiyo Saito, Eiichi Nishio, Emi Nishida, Yoichi Shintani, Akimichi Morita
  • Journal Title: Photoderm Photoimmunol Photomedicin Volume: 27 Issue: 3 Pages: 152-155
  • DOI: 10.1111/j.1600-0781.2011.00575.x
• [Journal Article] Increased peripheral TH17 in patients with palmoplantar pustulosis. (2011)
  • Author(s): Kan Torii, Takuya Furuhashi, Chiyo Saito,Hiroshi Kato, Akiko Nishioka, Emi Nishida, Yoichi Shintani, and Akimichi Morita
  • Journal Title: Arch Dermatol Res Volume: 303 Issue: 6 Pages: 441-444
  • DOI: 10.1007/s00403-010-1112-x
• [Journal Article] Phototherapy reduces serum resistin levels of psoriasis patients (2011)
  • Author(s): Kana Kawashima, Kan Torii, Takuya Furuhashi, Chiyo Saito, Eiichi Nishio, Emi Nishida, Yoichi Shintani, Akimichi Morita
  • Journal Title: Photoderm Photoimmunol Photomedicin Volume: 27 Pages: 152-155
  • Peer Reviewed
• [Journal Article] Increased peripheral Th17 in patients with palmoplantar pustulosis (2011)
  • Author(s): Kan Torii, Takuya Furuhashi, Chiyo Saito, Hiroshi Kato, Akiko Nishioka, Emi Nishida, Yoichi Shintani, and Akimichi Morita
  • Journal Title: Arch Dermatol Res Volume: 303 Pages: 441-444
  • Peer Reviewed
• [Presentation] Dual action operative mechanisms of phototherapy-the induction of apoptosis and regulatory T cells (2012)
  • Author(s): Akimichi Morita
  • Organizer: 2nd Eastern Asian Dermatology Congress
  • Place of Presentation: Beijing(特別講演)(中国)
  • Year and Date: 2012-06-14
• [Presentation] UVB irradiation with a monochromatic wavelength of 300-310 nm increases filaggrin expression in a three dimensional human skin model. (2012)
  • Author(s): Kan Torii, Akimichi Morita
  • Organizer: 2012 SID aanual meeting
  • Place of Presentation: North Carolina (米国)
• [Presentation] Photo (chemo)therapy reduces circulating Th17 cells and restores dysfunctional regulatory T cells in psoriasis. (2012)
  • Author(s): Takuya Furuhashi, Chiyo Saito, Kan Torii, Emi Nishida, Akimichi Morita
  • Organizer: 2012 SID aanual meeting
  • Place of Presentation: North Carolina(米国)
• [Presentation] UVB irradiation with a monochromatic wavelength of 300-310 nm increases filaggrin expression in a three dimensional human skin model. (2012)
  • Author(s): Kan Torii
  • Organizer: 2012 SID aanual meeting
  • Place of Presentation: Raleigh Convention Center（米国）
• [Presentation] Photo(chemo)therapy reduces circulating Th17 cells and restores dysfunctional regulatory T cells in psoriasis (2012)
  • Author(s): Takuya Furuhashi
  • Organizer: 2012 SID annual meeting
  • Place of Presentation: Raleigh Convention Center（米国）
• [Presentation] Dual action operative mechanisms of narrow-band UVB phototherapy (2011)
  • Author(s): Akimichi Morita
  • Organizer: 22nd World Congress of Dermatology
  • Place of Presentation: Seoul(韓国)
  • Year and Date: 2011-05-28
• [Presentation] UVA1 phototherapy for refractory skin diseases (2011)
  • Author(s): Akimichi Morita
  • Organizer: 22nd World Congress of Dermatology
  • Place of Presentation: Seoul(韓国)
  • Year and Date: 2011-05-26
• [Presentation] Bath-psoralen UVA and narrow-band UVB reduce circulating Th17 cells and induce circulating regulatory T cells in psoriasis (2011)
  • Author(s): Takuya Furuhashi, Chiyo Saito, Emi Nishida, Kan Torii, Akimichi Morita
  • Organizer: 2011 SID aanual meeting
  • Place of Presentation: Fenix(米国)
• [Presentation] Bath-psoralen UVA and narrow-band UVB reduce circulating Th17 cells and induce circulating regulatory T cells in psoriasis (2011)
  • Author(s): Takuya Furuhashi, Chiyo Saito, Emi Nishida, Kan Torii, Akimichi Morita
  • Organizer: 2011 SID aanual meeting
  • Place of Presentation: JW Marriott Desert Ridge Resort and Spa（アメリカ）
• [Presentation] UVA1 phototherapy for refractory skin diseases (2011)
  • Author(s): Akimichi Morita
  • Organizer: 22nd World Congress of Dermatology(招待講演)
  • Place of Presentation: Coex Center（韓国）
• [Presentation] Dual action operative mechanisms of narrow-band UVB phototherapy (2011)
  • Author(s): Akimichi Morita
  • Organizer: 22nd World Congress of Dermatology,
  • Place of Presentation: Coex Center（韓国）
• [Presentation] Dual action operative mechanisms of phototherapy-the induction of apoptosis and regulatory T cells,
  • Author(s): Akimichi Morita
  • Organizer: 2nd Eastern Asian Dermatology Congress
  • Place of Presentation: China National Convention Center（中国）
  • Invited
• [Remarks]
  • URL: http://www.med.nagoya-cu.ac.jp/derma.dir/index.htm
• [Remarks]
  • URL: http://www.med.nagoya-cu.ac.jp/derma.dir/research/index.html
• [Patent(Industrial Property Rights)] 紫外線照射の制御方法及び紫外線照射装置 (2012)
  • Inventor(s): 森田 明理稲田シュンコ アルバーノ
  • Industrial Property Rights Holder: 公立大学法人名古屋市立大学
  • Industrial Property Number: 2012-031201
  • Filing Date: 2012-02-16