• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Study of synthesis and metabolism of D-serine in the brain

Research Project

Project/Area Number 23659557
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionChiba University

Principal Investigator

HASHIMOTO Kenji  千葉大学, 社会精神保健教育研究センター, 教授 (10189483)

Co-Investigator(Renkei-kenkyūsha) IYO Masaomi  千葉大学, 大学院・医学研究院, 教授 (50191903)
MORI Hisashi  富山大学, 大学院・医学薬学研究部(医学), 教授 (00239617)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsD 型アミノ酸 / D 型セリン / D 型アスパラギン酸 / セリンラセマーゼ / D型アミノ酸 / D型セリン / D型アスパラギン酸 / 脳疾患 / NMDA受容体 / グルタミン酸受容体 / ピルビン酸 / 脳
Research Abstract

D-serine in the brain is known to be synthesized from serine racemase (SRR). In this study, we found that levels of D-aspartic acid I the forebrain of SRR knock-out (KO) mice was significantly lower than those of wild type mice. Furthermore, the enzymatic activity of D-aspartate oxidase (DDO) in the forebrain of SRR-KO mice was not changed. It is unlikely that DDO activity plays a role in the findings of this study.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (11 results)

All 2013 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (3 results) Remarks (2 results)

  • [Journal Article] (2013) Decreased levels of D-aspartic acid in the forebrain of serine racemase (Srr) knock-out mice.2013

    • Author(s)
      Horio, M., Ishima, T., Fujita, Y., Inoue, R., Mori, H., and Hashimoto, K.
    • Journal Title

      Neurochem. Int.

      Volume: 62 Pages: 843-847

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decreased levels of D-aspartic acid in the forebrain of serine racemase (Srr) knock-out mice2013

    • Author(s)
      Horio, M., Ishima, T., Fujita, Y., Inoue, R., Mori, H., and Hashimoto, K
    • Journal Title

      Neurochem. Int

      Volume: 62 Issue: 6 Pages: 843-847

    • DOI

      10.1016/j.neuint.2013.02.015

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Is D-cycloserine a prodrug forD-serine in the brain? Biol2013

    • Author(s)
      Horio, M., Mori, H., and Hashimoto, K
    • Journal Title

      Psychiatry

      Volume: (in press) Issue: 12 Pages: e33-e34

    • DOI

      10.1016/j.biopsych.2012.07.013

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] (2013) Is D-cycloserine a prodrug forD-serine in the brain? Biol.2012

    • Author(s)
      Horio, M., Mori, H., and Hashimoto, K.
    • Journal Title

      Psychiatry

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] (2011) Levels of D-serine in the brain and peripheral organs of serine racemase (Srr) knock-out mice.2011

    • Author(s)
      Horio, M., Kohno, M., Fujita, Y., Ishima, T., Inoue, R., Mori, H., and Hashimoto, K.
    • Journal Title

      Neurochem. Int.

      Volume: 59 Pages: 853-859

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Levels of D-serine in the brain and periphery.2011

    • Author(s)
      Horio M et al
    • Journal Title

      Neurochemistry International

      Volume: 59 Pages: 853-859

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] D-サイクロセリンは、脳においてD-セリ ンのプロドラッグか?2012

    • Author(s)
      堀尾菜央、森 寿、橋本謙二
    • Organizer
      第8回D-アミノ酸 研究会学術講演会
    • Place of Presentation
      滋賀県大津市
    • Related Report
      2012 Final Research Report
  • [Presentation] D-サイクロセリンは、脳においてD-セリンのプロドラッグか?2012

    • Author(s)
      堀尾菜央(橋本謙二)
    • Organizer
      第8回D-アミノ酸研究会学術講演会
    • Place of Presentation
      滋賀県大津市
    • Related Report
      2012 Annual Research Report
  • [Presentation] セリンラセマーゼ遺伝子欠損マウスでの覚せい剤投与 による行動感作の欠如2011

    • Author(s)
      堀尾菜央、河野眞美、藤田有子、井上 蘭、森 寿、橋本謙二
    • Organizer
      第7回D-アミノ酸 研究会学術講演会
    • Place of Presentation
      東京都
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.m.chiba-u.ac.jp/class/shakai/jp/index.html

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.m.chiba-u.ac.jp/class/shakai/jp/byoutai/index.html

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi