Development of a monitoring system of in vivo cell dynamics for therapeutic evaluation of psychiatric disorders
Project/Area Number |
23659562
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Psychiatric science
|
Research Institution | Hamamatsu University School of Medicine |
Principal Investigator |
OUCHI Yasuomi 浜松医科大学, メディカルフォトニクス研究センター, 教授 (40436978)
|
Co-Investigator(Kenkyū-buntansha) |
UEKI Takatoshi 浜松医科大学, 医学部, 准教授 (60317328)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 臨床精神分子遺伝学 / 神経幹細胞 |
Research Abstract |
It has been reported that neural stem cells are variously changed in the process of not only normal neural growth but also neuronal degeneration occurring in neuropsychiatric disorders. Despite these findings, there was no study about the contribution of neural stem cells to the physiological and pathophysiological significance. Hence we tried to develop an in vivo monitoring system with which the dynamics of the stem cells can be visualized. Using positron emission tomography with a new gene-reporter system and amino acid transporter, we were able to make a new in vivo system for measuring live neural stem cells in vivo specifically.
|
Report
(4 results)
Research Products
(21 results)
-
-
-
-
-
-
-
[Journal Article] In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer's disease2011
Author(s)
Yok oku r a M, Mo r i N, Yag i S, Yos h ik awa E, Kikuchi M, Yoshihara Y, Wakuda T, Sugihara G, Takebayashi K, Suda S, Iwata Y, Ueki T, Tsuchiya KJ, Suzuki K, Nakamura K, Ouchi Y
-
Journal Title
Eur J Nucl Med Mol Imaging
Volume: 38
Issue: 2
Pages: 343-51
DOI
Related Report
-
[Journal Article] Reduced acetylcholinesterase activity in the fusiform gyrus in adults with autism spectrum disorders2011
Author(s)
Suzuki K, Sugihara G, Ouchi Y, Nakamura K, Tsujii M, Futatsubashi M, Iwata Y, Tsuchiya KJ, Matsumoto K, Takebayashi K, Wakuda T, Yoshihara Y, Suda S, Kikuchi M, Takei N, Sugiyama T, Irie T, Mori N
-
Journal Title
Arch Gen Psychiatry
Volume: 68
Issue: 3
Pages: 306-13
DOI
Related Report
-
[Journal Article] Effects of brain amyloid deposition and reduced glucose metabolism on the default mode of brain function in normal aging2011
Author(s)
Kikuchi M, Hirosawa T, Yokokura M, Yagi S, Mori N, Yoshikawa E, Yoshihara Y, Sugihara G, Takebayashi K, Iwata Y, Suzuki K, Nakamura K, Ueki T, Minabe Y, Ouchi Y
-
Journal Title
Neurosci
Volume: 31
Issue: 31
Pages: 11193-9
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Effects of brain amyloid deposition and reduced glucose metabolism on the default mode of brain function in normal aging.2011
Author(s)
Kikuchi M, Hirosawa T, Yokokura M, Yagi S, Mori N, Yoshikawa E, Yoshihara Y, Sugihara G, Takebayashi K, Iwata Y, Suzuki K, Nakamura K, Ueki T, Minabe Y, Ouchi Y.
-
Journal Title
J Neurosci
Volume: 31
Pages: 11193-11199
Related Report
Peer Reviewed
-
-
[Journal Article] In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer’s disease.2011
Author(s)
Yokokura M, Mori N, Yagi S, Yoshikawa E, Kikuchi M, Yoshihara Y, Wakuta T, Sugihara G, Takebayashi K, Suda S, Iwata Y, Ueki T, Tsuchiya KJ, Suzuki K, Nakamura K, Ouchi Y.
-
Journal Title
Eur J Nucl Med Mol Imaging
Volume: 38
Pages: 343-351
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-