Development ofa new therapy by a risk gene for schizophrenia

• Project/Area Number: 23659565
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Osaka University
• Principal Investigator: HASHIMOTO Ryota 大阪大学, 大学院・連合小児発達学研究科, 准教授 (10370983)
• Co-Investigator(Kenkyū-buntansha): YASUDA Yuka 大阪大学, 大学院・医学系研究科, 特任研究員 (20448062) ; YAMAMORI Hidenaga 大阪大学, 大学院・医学系研究科, 寄附講座助教 (90570250)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 統合失調症 / 遺伝子 / 神経科学 / 生物学的精神医学

Research Abstract

The reduced expression level of dysbindin, which is a risk gene of schizophrenia, was observed in schizophrenia brain and the behavioral abnormalities similar to patients with schizophrenia were found in dysbindin deficient mouse. When PCP which causes the positive and negative sympotoms similar to schizophrenia were treated in dysbindin transgenic mouse overexpressing dysbindin protein, we found overexpression of dysbindin protein protected some behavioral abnormalities induced by PCP. Since change of the gene expression of transcription factors including EGR2 was found in dysbindin transgenic mouse, a possibility that the dysbindin signaling pathway through a transcription factor was participating in the protective action was suggested.

Research Products

• [Journal Article] The KCNH2 gene is associated with neurocognition and the risk of schizophrenia. (2013)
  • Author(s): Hashimoto R, Ohi K, Yasuda Y, Fukumnoto M, Yamamori H, Kamino K, Morihara T, Iwase M, Kazui H, Takeda M.
  • Journal Title: World J Biol Psychiatry. Volume: 14(2) Pages: 114-20
  • Peer Reviewed
• [Journal Article] The AKT1 gene is associated with attention and brain morphology in schizophrenia (2013)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Nemoto K, Ohnishi T, Yamamori H, Takahashi H, Iike N, Kamino K, Yoshida T, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Iwase M, Kazui H, Takeda M.
  • Journal Title: World J Biol Psychiatry. Volume: 14(2) Pages: 100-13
  • Peer Reviewed
• [Journal Article] The regulation of gene expression involved in TGF-β signaling by ZNF804A, a risk gene for schizophrenia. (2013)
  • Author(s): Umeda-Yano S, Hashimoto R, Yamamori H, Okada T, Yasuda Y, Ohi K, Fukumoto M, Ito A, Takeda M.
  • Journal Title: Schizophr Res
  • Peer Reviewed
• [Journal Article] An association analysis of the cardiomyopathy-associated 5(CMYA5) gene with schizophrenia in a Japanese population (2013)
  • Author(s): Furukawa M, Tochigi M, Otowa T, Arinami T, Inada T, Ujike H, Watanabe Y, Iwata N , Itokawa M, Kunugi H, Hashimoto R, Ozaki N, Kakiuchi C, Kasai K, Sasaki T
  • Journal Title: Psychiatr Genet
  • Peer Reviewed
• [Journal Article] The regulation of gene expression involved in TGF-β signaling by ZNF804A, a risk gene for schizophrenia. (2013)
  • Author(s): Umeda-Yano S, et al.
  • Journal Title: Schizophr Res, Volume: e-pub
  • Peer Reviewed
• [Journal Article] An association analysis of the cardiomyopathy-associated 5(CMYA5) gene with schizophrenia in a Japanese population. (2013)
  • Author(s): Furukawa M, et al,
  • Journal Title: Psychiatr Genet Volume: e-pub
  • Peer Reviewed
• [Journal Article] Analysis of the VAV3 as candidate gene for schizophrenia: evidences from voxel based morphometry and mutation screening (2012)
  • Author(s): Aleksic B., Kushima I, Hashimoto R, Ohi K, Ikeda M, Yoshimi A, Nakamura Y, Ito Y, Okochi T, Fukuo Y, Yasuda Y, Fukumoto M, Yamamori H, Ujike H, Suzuki M, Inada T, Takeda M, Kaibuchi K, Iwata N, Ozaki N.
  • Journal Title: Schizophrenia Bulletin
  • Peer Reviewed
• [Journal Article] Discrimination of schizophrenic females from healthy women using multiple structural brain measures obtained with voxel-based morphometry (2012)
  • Author(s): Ota M, Sato N, Ishikawa M, Hori H, Sasayama D, Hattori K, Teraishi T, Obu S, Nakata Y, Nemoto K, Moriguchi Y, Hashimoto R, Kunugi H.
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 66(7) Pages: 611-7
  • Peer Reviewed
• [Journal Article] Itakura M, Takeda M, Ohmori T. Meta-analysis of association studies between DISC1 missense variants and schizophrenia in Japanese population. (2012)
  • Author(s): Kinoshita M, Numata S, Tajima A, Ohi K, Hashimoto R, Shimodera S, Imoto I, Itakura M, Takeda M, Ohmori T.
  • Journal Title: Schizophr Res Volume: 141(2-3) Pages: 271-3
  • Peer Reviewed
• [Journal Article] Expression analysis of a novel mRNA variant of the schizophrenia risk gene ZNF804A (2012)
  • Author(s): Okada T, Hashimoto R, Yamamori H, Umeda-Yano S, Yasuda Y, Ohi K, Fukumoto M, Ikemoto K, KUnii Y, Tomita H, Ito A, Takeda M.
  • Journal Title: Schizophr Res Volume: 141(2-3) Pages: 277-8
  • Peer Reviewed
• [Journal Article] No Associations Found between the Genes Situated at 6p22.1, HIST1H2BJ, PRSS16 and PGBD1 in Japanese Patients Diagnosed With Schizophrenia. (2012)
  • Author(s): Kitazawa M, Ohnuma T, Takebayashi Y, Shibata N, Baba H, Ohi K, Yasuda Y, Nakamura Y, Aleksic B, Yoshimi A, Okochi T, Ikeda M, Naitoh H, Hashimoto R, Iwata N, Ozaki N, Takeda M.
  • Journal Title: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Volume: 159B(4) Pages: 456-64
  • Peer Reviewed
• [Journal Article] Personality traits and schizophrenia: evidence from a case-control study and meta-analysis. (2012)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Iwase M, Kazui H, Takeda M.
  • Journal Title: Psychiatry Research Volume: 198(1) Pages: 7-11
  • Peer Reviewed
• [Journal Article] Functional genetic variation at the NRGN gene and schizophrenia: evidence from a gene-based case-control study and gene expression analysis. (2012)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Okada T, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ohmura T, Iwata N, Ueno S, Ozaki N, Ohmori T, Arai H, Takeda M.
  • Journal Title: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Volume: 159B(4) Pages: 405-13
  • Peer Reviewed
• [Journal Article] Searching for a consensus five-factor model of the Positive and Negative Syndrome Scale for schizophrenia. (2012)
  • Author(s): Wallwork RS, Fortgang R, Hashimoto R, Weinberger DR, Dickinson D.
  • Journal Title: Schizophr Res Volume: (Schizophr Res) Pages: 246-50
  • Peer Reviewed
• [Journal Article] A two-stage case-control association study between the tryptophan hydroxylase 2(TPH2) gene and schizophrenia in a Japanese population (2012)
  • Author(s): Watanabe Y, Egawa J, Iijima Y, Nunokawa A, Kaneko N, Shibuya M, Arinami T, Ujike H, Inada T, Iwata N, Tochigi M, Kunugi H, Itokawa Ma, Ozaki N, Hashimoto R, Someya T.
  • Journal Title: Schizophrenia Research Volume: 137 Pages: 264-266
  • Peer Reviewed
• [Journal Article] Common Variants in MAGI2 Gene Are Associated with Increased Risk for Cognitive Impairment in Schizophrenic Patients. (2012)
  • Author(s): Koide T, Banno M, Aleksic B, Yamashita S, Kikuchi T, Kohmura K, Adachi Y, Kawano N, Kushima I, Nakamura Y, Okada T, Ikeda M, Ohi K, Yasuda Y, Hashimoto R, Inada T, Ujiike H, Iidaka T, Suzuki M, Takeda M, Iwata N, Ozaki N.
  • Journal Title: PLos One Volume: 7(5)
  • Peer Reviewed
• [Journal Article] Resequencing and Association Analysis of the KALRN and EPHB1 Genes And Their Contribution to Schizophrenia Susceptibility. (2012)
  • Author(s): Kushima I, Nakamura Y, Aleksic B, Ikeda M, Ito Y, Shiino T, Okochi T, Fukuo Y, Ujike H, Suzuki M, Inada T, Hashimoto R, Takeda M, Kaibuchi K, Iwata N, Ozaki N
  • Journal Title: Schizophr Bull Volume: 38(3) Pages: 552-560
  • Peer Reviewed
• [Journal Article] The p250GAP Gene is Associated with Risk for Schizophrenia and Schizotypal Personality Traits. (2012)
  • Author(s): Ohi K, Hashimoto R, Nakazawa T, Okada T, Yasuda Y, Yamamori H, Fukumoto M, Umeda-Yano S, Iwase M, Kazui H, Yamamoto T, Kano M, Takeda M.
  • Journal Title: PLoS One Volume: 7(4)
  • Peer Reviewed
• [Journal Article] A promoter variant in the Chitinase 3-Like 1 gene is associated with serum YKL-40 level and personality trait. (2012)
  • Author(s): Yamamori H, Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Kasahara E, Sekiyama A, Umeda-Yano S, Okada T, Iwase M, Kazui H, Ito A, Takeda M
  • Journal Title: Neurosci Lett Volume: 513(3) Pages: 204-208
  • Peer Reviewed
• [Journal Article] Relationship of Prepulse Inhibition to Temperament and Character in Healthy Japanese subjects (2012)
  • Author(s): Takahashi H, Iwase M, Yasuda Y, Ohi Y, Fukumoto M, Iike N, Yamamori H, Nakahachi T, Ikezawa K, Azechi M, Canuet L, Ishii R, Kazui H, Hashimoto R, Takeda M.
  • Journal Title: Neuroscience Research Volume: 72(2) Pages: 187-193
  • Peer Reviewed
• [Journal Article] Impact of the Genome Wide Supported NRGN Gene on Anterior Cingulate Morphology in Schizophrenia. (2012)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Nemoto K, Ohnishi T, Fukumoto M, Yamamori H, Umeda-Yano S. Okada T, Iwase M, Kazui H, Takeda M.
  • Journal Title: PLoS One Volume: 7(1)
  • Peer Reviewed
• [Journal Article] Analysis of the VAV3 as candidate gene for schizophrenia: evidences from voxel based morphometry and mutation screening. (2012)
  • Author(s): Aleksic B., et al
  • Journal Title: Schizophrenia Bulletin. Volume: e-pub
  • Peer Reviewed
• [Journal Article] Discrimination of schizophrenic females from healthy women using multiple structural brain measures obtained with voxel-based morphometry. (2012)
  • Author(s): Ota M, et al,
  • Journal Title: Psychiatry and Clinical Neurosciences, Volume: 66(7): Issue: 7 Pages: 611-7
  • DOI: 10.1111/j.1440-1819.2012.02397.x
  • Peer Reviewed
• [Journal Article] Meta-analysis of association studies between DISC1 missense variants and schizophrenia in Japanese population. (2012)
  • Author(s): Kinoshita M, et al
  • Journal Title: Schizophr Res, Volume: 141(2-3): Issue: 2-3 Pages: 271-273
  • DOI: 10.1016/j.schres.2012.07.020
  • Peer Reviewed
• [Journal Article] Expression analysis of a novel mRNA variant of the schizophrenia risk gene ZNF804A. (2012)
  • Author(s): Okada T, et al,
  • Journal Title: Schizophr Res, Volume: 141(2-3): Issue: 2-3 Pages: 277-278
  • DOI: 10.1016/j.schres.2012.08.015
  • Peer Reviewed
• [Journal Article] No associations found between the genes situated at 6p22.1, HIST1H2BJ, PRSS16, and PGBD1 in Japanese patients diagnosed with schizophrenia (2012)
  • Author(s): Kitazawa M, Ohnuma T, Takebayashi Y, Shibata N, Baba H, Ohi K, Yasuda Y, Nakamura Y, Aleksic B, Yoshimi A, Okochi T, Ikeda M, Naitoh H, Hashimoto R, Iwata N, Ozaki N, Takeda M, Arai H
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet Volume: 159B(4) Issue: 4 Pages: 456-464
  • DOI: 10.1002/ajmg.b.32049
  • Peer Reviewed
• [Journal Article] Personality traits and schizophrenia : evidence from a case-control study and meta-analysis (2012)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Iwase M, Kazui H, Takeda M
  • Journal Title: Psychiatry Res Volume: (Epub ahead of print) Issue: 1 Pages: 7-11
  • DOI: 10.1016/j.psychres.2011.12.018
  • Peer Reviewed
• [Journal Article] Functional genetic variation at the NRGN gene and schizophrenia: Evidence from a gene-based case-control study and gene expression analysis (2012)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Okada T, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ohnuma T, Iwata N, Ueno S, Ozaki N, Ohmori T, Arai H, Takeda M
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet Volume: 159B(4) Issue: 4 Pages: 405-413
  • DOI: 10.1002/ajmg.b.32043
  • Peer Reviewed
• [Journal Article] Searching for a consensus five-factor model of the Positive and Negative Syndrome Scale for schizophrenia. (2012)
  • Author(s): Wallwork RS, et al
  • Journal Title: Schizophr Res, Volume: 137(1-3): Issue: 1-3 Pages: 246-50
  • DOI: 10.1016/j.schres.2012.01.031
  • Peer Reviewed
• [Journal Article] A two-stage case-control association study between the tryptophan hydroxylase 2 (TPH2) gene and schizophrenia in a Japanese population (2012)
  • Author(s): Watanabe Y, Egawa J, Iijima Y, Nunokawa A, Kaneko N, Shibuya M, Arinami T, Ujike H, Inada T, Iwata N, Tochigi M, Kunugi H, Itokawa M, Ozaki N, Hashimoto R, Someya T
  • Journal Title: Schizophr Res Volume: 137(1-3) Issue: 1-3 Pages: 264-266
  • DOI: 10.1016/j.schres.2012.01.034
  • Peer Reviewed
• [Journal Article] Common Variants in MAGI2 Gene Are Associated with Increased Risk for Cognitive Impairment in Schizophrenic Patients (2012)
  • Author(s): Koide T, Banno M, Aleksic B, Yamashita S, Kikuchi T, Kohmura K, Adachi Y, Kawano N, Kushima I, Nakamura Y, Okada T, Ikeda M, Ohi K, Yasuda Y, Hashimoto R, Inada T, Ujike H, Iidaka T, Suzuki M, Takeda M, Iwata N, Ozaki N
  • Journal Title: PLoS One Volume: 7(5) Issue: 5 Pages: e36836-e36836
  • DOI: 10.1371/journal.pone.0036836
  • Peer Reviewed
• [Journal Article] Resequencing and Association Analysis of the KALRN and EPHB1 Genes And Their Contribution to Schizophrenia Susceptibility (2012)
  • Author(s): Kushima I, Nakamura Y, Aleksic B, Ikeda M, Ito Y, Shiino T, Okochi T, Fukuo Y, Ujike H, Suzuki M, Inada T, Hashimoto R, Takeda M, Kaibuchi K, Iwata N, Ozaki N
  • Journal Title: Schizophr Bull Volume: 38(3) Issue: 3 Pages: 552-560
  • DOI: 10.1093/schbul/sbq118
  • Peer Reviewed
• [Journal Article] The p250GAP gene is associated with risk for schizophrenia and schizotypal personality traits (2012)
  • Author(s): Hashimoto R
  • Journal Title: PLoS ONE Volume: 7 Issue: 4 Pages: e35696-e35696
  • DOI: 10.1371/journal.pone.0035696
  • Peer Reviewed
• [Journal Article] Discrimination of schizophrenic females from healthy women using multiple structural brain measures obtained with voxel-based morphometry. (2012)
  • Author(s): Ota M, Hashimoto R, et al.
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: in press
  • Peer Reviewed
• [Journal Article] Functional genetic variation at the NRGN gene and schizophrenia: evidence from a gene-based case-control study and gene expression analysis. (2012)
  • Author(s): Ohi K, Hashimoto R, et al.
  • Journal Title: American Journal of Medical Genetics Part B: Volume: in press
  • Peer Reviewed
• [Journal Article] Analysis of the VAV3 as candidate gene for schizophrenia: evidences from voxel based morphometry and mutation screening. (2012)
  • Author(s): Aleksic B., Hashimoto R, et al
  • Journal Title: Schizophrenia Bulletin Volume: in press
  • Peer Reviewed
• [Journal Article] A promoter variant in the Chitinase 3-Like 1 gene is associated with serum YKL-40 level and personality trait. (2012)
  • Author(s): Yamamori H, Hashimoto R, et al
  • Journal Title: Neuroscience Letters Volume: in press
  • Peer Reviewed
• [Journal Article] A two-stage case-control association study between the tryptophan hydroxylase 2(TPH2) gene and schizophrenia in a Japanese population. (2012)
  • Author(s): Watanabe Y, Hashimoto R, et al
  • Journal Title: Schizophrenia Research Volume: in press
  • Peer Reviewed
• [Journal Article] Personality traits and schizophrenia: evidence from a case-control studyand meta-analysis. (2012)
  • Author(s): Ohi K, Hashimoto R, et al.
  • Journal Title: Psychiatry Research Volume: in press
  • Peer Reviewed
• [Journal Article] Relationship of prepulse inhibition to temperament and character in healthy Japanese subjects (2012)
  • Author(s): Takahashi H, Iwase M, Yasuda Y, Ohi K, Fukumoto M, Iike N, Yamamori H, Nakahachi T, Ikezawa K, Azechi M, Canuet L, Ishii R, Kazui H, Hashimoto R, Takeda M
  • Journal Title: Neurosci Res Volume: 72(2) Issue: 2 Pages: 187-193
  • DOI: 10.1016/j.neures.2011.10.009
  • Peer Reviewed
• [Journal Article] Impact of the genome wide supported NRGN gene on anterior cingulate morphology in schizophrenia (2012)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Nemoto K, Ohnishi T, Fukumoto M, Yamaniori H, Umeda-Yano S, Okada T, Iwase M, Kazui H, Takeda M
  • Journal Title: PLoS One Volume: 7(1) Issue: 1 Pages: e29780-e29780
  • DOI: 10.1371/journal.pone.0029780
  • Peer Reviewed
• [Journal Article] A polymorphism of the ABCA1 gene confers susceptibility to schizophrenia and related brain changes. (2011)
  • Author(s): Ota M, Fujii T, Nemoto K, Tatsumi M, Moriguchi Y, Hashimoto R, Sato N, Iwata N, Kunugi H.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry. Volume: 35(8) Pages: 1877-1883
  • Peer Reviewed
• [Journal Article] Decreased alpha event-related synchronization in the left posterior temporal cortex in schizophrenia: A magnetoencephalography-beamformer study. (2011)
  • Author(s): Ikezawa K, Ishii R, Iwase M, Kurimoto R, Canuet L, Takahashi H, Nakahachi T, Azechi M, Ohi K, Fukumoto M, Yasuda Y, Iike N, Takaya M, Yamamori H, Kazui H, Hashimoto R, Yoshimine T, Takeda M.
  • Journal Title: Neurosci Res Volume: 71(3) Pages: 235-43
  • Peer Reviewed
• [Journal Article] Variants of the RELA gene are associated with schizophrenia and their startle responses (2011)
  • Author(s): Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Takahashi H, Iwase M, Okochi T, Kazui H, Saitoh O, Tatsumi M, Iwata N, Ozaki N, Kamijima K, Kunugi H, Takeda M.
  • Journal Title: Neuropsychopharmacology Volume: 36(9) Pages: 1921-1931
  • Peer Reviewed
• [Journal Article] Dysbindin-1 and NRG-1 gene expression in immortalized lymphocytes from patients with schizophrenia (2011)
  • Author(s): Yamamori H, Hashimoto R, Verrall L, Yasuda Y, Ohi K, Fukumoto M, Umeda-Yano S, Ito A, Takeda M
  • Journal Title: J Hum Genet Volume: 56(7) Pages: 478-83
  • NAID: 10030659941
  • Peer Reviewed
• [Journal Article] Gene expression analysis in lymphoblasts derived from patients with autism spectrum disorder (2011)
  • Author(s): Yasuda Y, Hashimoto R, Yamamori H, Ohi K, Fukumoto M, Umeda-Yano S, Mohri I, Ito A, Taniike M, Takeda M.
  • Journal Title: Molecular Autism Volume: 2(1) Pages: 9-9
  • NAID: 40019049794
  • Peer Reviewed
• [Journal Article] No association between the PCM1 gene and schizophrenia: a multi-center case-control study and a meta-analysis. (2011)
  • Author(s): Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Kamino K, Morihara T, Iwase M, Kazui H, Numata S, Ikeda M, Ueno S, Ohmori T, Iwata N, Ozaki N, Takeda M
  • Journal Title: Schizophrenia Res Volume: 129 Pages: 80-84
  • Peer Reviewed
• [Journal Article] Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene (2011)
  • Author(s): Yasuda Y, Hashimoto R, Ohi K , Fukumoto M, Umeda-Yano S, Yamamori H, Okochi T, Iwase M, Kazui H, Iwata N, Takeda M.
  • Journal Title: Neurosci let Volume: 495 Pages: 216-220
  • Peer Reviewed
• [Journal Article] PACAP is Implicated in the Stress Axes (2011)
  • Author(s): Hashimoto H, Shintani N, Tanida M, Hayata A, Hashimoto R, Baba A
  • Journal Title: Curr Pharm Des, review Volume: 17(10) Pages: 985-9
  • Peer Reviewed
• [Journal Article] The SIGMAR1 gene is associated with a risk of schizophrenia and activation of the prefrontal cortex. (2011)
  • Author(s): Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Yamamori H, Umeda-Yano S, Kamino K, Ikezawa K, Azechi M, Iwase M, Kazui H, Kasai K, Takeda M
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 35 Pages: 1309-1315
  • Peer Reviewed
• [Journal Article] The AKT1 gene is associated with attention and brain morphology in schizophrenia (2011)
  • Author(s): Ohi K, Hashimoto R, et al
  • Journal Title: World J Biol Psychiatry Volume: e-pub Issue: 2 Pages: 100-13
  • DOI: 10.3109/15622975.2011.591826
  • Peer Reviewed
• [Journal Article] The KCNH2 gene is associated with neurocognition and the risk of schizophrenia (2011)
  • Author(s): Hashimoto R, et al
  • Journal Title: World J Biol Psychiatry. Volume: e-pub Issue: 2 Pages: 114-20
  • DOI: 10.3109/15622975.2011.604350
  • Peer Reviewed
• [Journal Article] A polymorphism of the ABCA1 gene confers susceptibility to schizophrenia and related brain changes (2011)
  • Author(s): Ota M, Fujii T, Nemoto K, Tatsumi M, Moriguchi Y, Hashimoto R, et al
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 35(8) Issue: 8 Pages: 1877-1883
  • DOI: 10.1016/j.pnpbp.2011.07.012
  • Peer Reviewed
• [Journal Article] Variants of the RELA gene are associated with schizophrenia and their startle responses. (2011)
  • Author(s): Hashimoto R, et al.
  • Journal Title: Neuropsychopharmacology Volume: 36(9) Pages: 1921-1931
  • Peer Reviewed
• [Journal Article] Dysbindin-1 and NRG-1 gene expression in immortalized lymphocytes from patients with schizophrenia. (2011)
  • Author(s): Yamamori H, Hashimoto R, et al
  • Journal Title: J Hum Genet Volume: 56(7) Issue: 7 Pages: 478-83
  • DOI: 10.1038/jhg.2011.40
  • NAID: 10030659941
• [Journal Article] Gene expression analysis in lymphoblasts derived from patients with autism spectrum disorder (2011)
  • Author(s): Yasuda Y, Hashimoto R, et al
  • Journal Title: Molecular Autism Volume: 2(1) Issue: 1 Pages: 9-9
  • DOI: 10.1186/2040-2392-2-9
  • NAID: 40019049794
  • Peer Reviewed
• [Journal Article] No association between the PCM1 gene and schizophrenia : a multi-center case-control study and a meta-analysis (2011)
  • Author(s): Hashimoto R, et al
  • Journal Title: Schizophrenia Research Volume: 129 Issue: 1 Pages: 80-84
  • DOI: 10.1016/j.schres.2011.03.024
  • Peer Reviewed
• [Journal Article] Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene (2011)
  • Author(s): Yasuda Y, et al
  • Journal Title: Neuroscience Letters Volume: 495 Issue: 3 Pages: 216-220
  • DOI: 10.1016/j.neulet.2011.03.069
  • Peer Reviewed
• [Journal Article] PACAP is Implicated in the Stress Axes. (2011)
  • Author(s): Hashimoto H, Hashimoto R, et al.
  • Journal Title: Curr Pharm Des Volume: 17(10) Pages: 985-9
  • Peer Reviewed
• [Presentation] Genome-wide association study of cognitive decline in schizophrenia (2013)
  • Author(s): Hashimoto R, Ikeda M, Kazutaka O, Yasuda Y, Yamamori H, Fukumoto M, Umeda-Yano S, Dickinson D, Aleksic B, Iwase M, Kazui H, Ozaki N, Weinberger DR, Iwata N, Takeda M.
  • Organizer: The 3rdAsian Congress on Schizophrenia Research
  • Place of Presentation: Bali, Indonesia
• [Presentation] Genome-wide association study of cognitive decline in schizophrenia (2013)
  • Author(s): Hashimoto R
  • Organizer: The 3rd Asian Congress on Schizophrenia Research,
  • Place of Presentation: Indonesia
  • Invited
• [Presentation] The p250GAP Gene is Associated with Risk for Schizophrenia and Schizotypal Personality Trait (2012)
  • Author(s): Hashimoto R, Ohi K, Nakazawa T, Yasuda Y, Yamamori H, Fukumoto M, Iwase M, Kazui H, Yamamoto T, Kano M, Takeda M.
  • Organizer: CNIP 28th CINP World Congress of Neuropsychopharmacology.
  • Place of Presentation: Stockholm, Sweden
• [Presentation] 統合失調症入院プログラムにおける治療抵抗性統合失調症に対するclozapine の有用性 (2012)
  • Author(s): 橋本亮太、山森英長、安田由華、福本素由己、大井一高、井上頌子、竹上学、武田雅俊
  • Organizer: 第22回日本臨床精神神経薬理学会第42回日本神経精神薬理学会合同年
  • Place of Presentation: 栃木
• [Presentation] Variants of the RELA gene are associated with schizophrenia and their startle responses. (2012)
  • Author(s): Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Takahashi H, Iwase M, Okochi T, Kazui H, Saitoh O, Tatsumi M, Iwata N, OzakiN, Kamijima K, Kunugi H, Takeda M.
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸
• [Presentation] 広汎性発達障害の原因遺伝子とその探索ストラテジー- Research strategy for identifying ASD genes- (2012)
  • Author(s): 橋本亮太、安田由華、山森英長、梅田知美、深井綾子、大井一高、福本素由己、毛利育子、谷池雅子、松本直通、武田雅俊
  • Organizer: 第34回日本生物学的精神医学会、第11回アジア太平洋神経化学会大会・第55回日本神経化学会大会合同シンポジウム
  • Place of Presentation: 神戸
• [Presentation] 「ゲノム研究による精神疾患診断は可能か?」、シンポジウム:バイオロジカルマーカー研究からDSM-V に向けて (2012)
  • Author(s): 橋本亮太、大井一高、安田由華、山森英長、梅田知美、福本素由己、武田雅俊
  • Organizer: Biological marker research towards DSM-V、第34回日本生物学的精神医学会
  • Place of Presentation: 神戸
• [Presentation] シンポジウム:統合失調症の分子メカニズム研究の新しい潮流:中間表現型を用いた統合失調症の病態解明 (2012)
  • Author(s): 橋本亮太、大井一高、安田由華、山森英長、梅田知美、岩瀬真生、数井裕光、武田雅俊
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 愛知
• [Presentation] ヒトにおける脳表現型の分子機構の解明:ヒト脳表現型コンソーシアムについて (2012)
  • Author(s): 橋本亮太、大井一高、安田由華、梅田知美、山森英長、武田雅俊
  • Organizer: 2012 年度包括脳ネットワーク夏のワークショップ
  • Place of Presentation: 仙台
• [Presentation] 阪大病院における 20 症例の治療抵抗性統合失調症患者へのクロザピンの使用経験 (2012)
  • Author(s): 橋本亮太、山森英長、安田由華、福本素由己、大井一高、梅田知美、岡田武也、武田雅俊
  • Organizer: 第108回日本精神神経学会学術総会
  • Place of Presentation: 札幌
• [Presentation] 統合失調症専門外来・入院プログラムによる地域医療と臨床研究の融合システムの構築 (2012)
  • Author(s): 橋本亮太、大井一高、安田由華、山森英長、福本素由己、梅田知美、岡田武也、武田雅俊
  • Organizer: 第108回日本精神神経学会学術総会、第108回日本精神神経学会学術総会
  • Place of Presentation: 札幌
• [Presentation] The p250GAP Gene is Associated with Risk for Schizophrenia and Schizotypal Personality Trait. (2012)
  • Author(s): Hashimoto R
  • Organizer: 28th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Sweden
• [Presentation] 統合失調症入院プログラムにおける治療抵抗性統合失調症に対するclozapineの有用性 (2012)
  • Author(s): 橋本亮太
  • Organizer: 第22回日本臨床精神神経薬理学会第42回日本神経精神薬理学会合同年会
  • Place of Presentation: 栃木
• [Presentation] 広汎性発達障害の原因遺伝子とその探索ストラテジー- Research strategy for identifying ASD genes- (2012)
  • Author(s): 橋本亮太
  • Organizer: 第34回日本生物学的精神医学会、第11回アジア太平洋神経化学会大会・第55回日本神経化学会大会
  • Place of Presentation: 神戸
  • Invited
• [Presentation] ゲノム研究による精神疾患診断は可能か？ (2012)
  • Author(s): 橋本亮太
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸
  • Invited
• [Presentation] 統合失調症の分子メカニズム研究の新しい潮流：中間表現型を用いた統合失調症の病態解明 (2012)
  • Author(s): 橋本亮太
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 愛知
  • Invited
• [Presentation] ヒトにおける脳表現型の分子機構の解明：ヒト脳表現型コンソーシアムについて (2012)
  • Author(s): 橋本亮太
  • Organizer: 2012年度包括脳ネットワーク夏のワークショップ
  • Place of Presentation: 仙台
• [Presentation] 阪大病院における20症例の治療抵抗性統合失調症患者へのクロザピンの使用経験 (2012)
  • Author(s): 橋本亮太
  • Organizer: 第108回日本精神神経学会学術総会
  • Place of Presentation: 札幌
• [Presentation] 統合失調症専門外来・入院プログラムによる地域医療と臨床研究の融合システムの構築、 (2012)
  • Author(s): 橋本亮太
  • Organizer: 第108回日本精神神経学会学術総会
  • Place of Presentation: 札幌
• [Presentation] The KCNH2 gene is associated with neurocognition and the risk of schizophrenia (2011)
  • Author(s): Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Kamino K, Morihara T, Iwase M, Kazui H, Takeda M
  • Organizer: 2nd Congress of AsCNP
  • Place of Presentation: Seoul, Korea
• [Presentation] Variants of the RELA gene are associated with schizophrenia and their startle responses. (2011)
  • Author(s): Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Yamamori H, Takahashi H, Iwase M, Okochi T, Kazui H, Saitoh O, Tatsumi M, Iwata N, OzakiN, Kamijima K, Kunugi H, Takeda M.
  • Organizer: 19th World Congress of Psychiatric Genetics
  • Place of Presentation: Washington D.C., U.S.A.
• [Presentation] Dysbindin: Possible target molecule for antipsychotic development. (2011)
  • Author(s): Hashimoto R, Yasuda Y, Ohi K, Fukumoto M, Yamamori H, Takeda M.
  • Organizer: 10th World Congress of Biological Psychiatry
  • Place of Presentation: Prague, Czech Republic
• [Presentation] 統合失調症の候補遺伝子の精神生物学、第54回日本神経化学会大会 (2011)
  • Author(s): 橋本亮太、安田由華、大井一高、福本素由己、山森英長、梅田知美、岡田武也、高雄啓三、小林克典、楯林義孝、宮川剛、貝淵弘三、岩田仲生、尾崎紀夫、武田雅俊
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 石川
• [Presentation] ヒト脳表現型と分子を結ぶ新しいアプローチ:ヒト脳表現型コンソーシアム (2011)
  • Author(s): 橋本亮太、大井一高、安田由華、福本素由己、山森英長、梅田知美、岡田武也、岩瀬真生、数井裕光、武田雅俊
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 石川
• [Presentation] 統合失調症の中間表現型研究の最前線-The front line of intermediate phenotype study in schizophrenia- (2011)
  • Author(s): 橋本亮太、大井一高、安田由華、福本素由己、山森英長、梅田知美、岩瀬真生、数井裕光、武田雅俊
  • Organizer: 第33回日本生物学的精神医学会
  • Place of Presentation: 東京
• [Presentation] The KCNH2 gene is associated with neurocognition and the risk of schizophrenia. (2011)
  • Author(s): Hashimoto R
  • Organizer: 2nd Congress of AsCNP
  • Place of Presentation: Seoul, Korea
• [Presentation] Variants of the RELA gene are associated with schizophrenia and their startle responses. (2011)
  • Author(s): Hashimoto R
  • Organizer: 19th World Congress of Psychiatric Genetics
  • Place of Presentation: Washington D.C., U.S.A
• [Presentation] Dysbindin: Possible target molecule for antipsychotic development. (2011)
  • Author(s): Hashimoto R
  • Organizer: 10th World Congress of Biological Psychiatry(招待講演)
  • Place of Presentation: Prague, Czech Republic
• [Presentation] 統合失調症の候補遺伝子の精神生物学 (2011)
  • Author(s): 橋本亮太
  • Organizer: 第54回日本神経化学会大会(招待講演)
  • Place of Presentation: 石川
• [Presentation] ヒト脳表現型と分子を結ぶ新しいアプローチ：ヒト脳表現型コンソーシアム (2011)
  • Author(s): 橋本亮太
  • Organizer: 第54回日本神経化学会大会(招待講演)
  • Place of Presentation: 石川
• [Presentation] 統合失調症の中間表現型研究の最前線-The front line of intermediate phenotype study in schizophrenia- (2011)
  • Author(s): 橋本亮太
  • Organizer: 第33回日本生物学的精神医学会(招待講演)
  • Place of Presentation: 東京
• [Book] 統合失調症入院プログラムにおける治療抵抗性統合失調症に対するclozapine の 有用性 (2012)
  • Author(s): 橋本亮太、山森英長、安田由華、福本素由己、大井一高、井上頌子、竹上学、武田雅俊
  • Publisher: 星和書店
• [Book] 臨床精神薬理：統合失調症入院プログラムにおける治療抵抗性統合失調症に対するclozapineの有用性 (2012)
  • Author(s): 橋本亮太
  • Publisher: 星和書店
• [Book] 中間表現型、精神医学キーワード事典 (2011)
  • Author(s): 橋本亮太、武田雅俊
  • Publisher: 中山
• [Book] 中間表現型、精神医学キーワード事典 (2011)
  • Author(s): 橋本亮太、武田雅俊
  • Publisher: 中山書店
• [Remarks]
  • URL: http://www.sp-web.sakura.ne.jp/lab/index.html
• [Remarks]
  • URL: http://www.sp-web.sakura.ne.jp/lab/index.html