Gene expression studies in delayed carbon monoxide encephalopathy rat model.

• Project/Area Number: 23659567
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Ehime University
• Principal Investigator: UENO Shuichi 愛媛大学, 大学院・医学系研究科, 教授 (80232768)
• Co-Investigator(Renkei-kenkyūsha): YOSHIDA Kenichi 東京大学, 大学院・医学系研究科・公共健康医学専攻, 教授 (40166947)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 一酸化炭素 / 遅発性神経細胞障害 / ラット / 受動的回避試験 / DNA チップ / DNAチップ / 動物モデル / 遺伝子発現

Research Abstract

Delayed carbon monoxide encephalopathy is a serious organic brain disorder but its mechanism is not known yet. In this study, we made the delayed carbon monoxide encephalopathy rat model and analyzed the behavior with passive avoidance test and gene expressions with DNA chip. The latencies in passive-avoidance test were significantly shorter two weeks after carbon monoxide treatment. However, there were no gene expressional changes in the hippocampus three weeks after treatment. Further studies should be needed to clarify it.

Research Products

• [Journal Article] Heteroplasmic m.1624C>T mutation of the mitochondrial tRNAVal gene in a proband and his mother with repeated consciousness disturbances (2012)
  • Author(s): Y. Sangatsuda, M. Nakamura, A. Tomiyasu, A. Deguchi, Y. Toyota, Y. Goto, I. Nishino, S. Ueno, A. Sano
  • Journal Title: Mitochondrion Volume: 12 Pages: 617-622
  • Peer Reviewed
• [Journal Article] Ohmori Gene expression and association analysis of the epithelial membrane protein 1 gene in major depressive disorder in the Japanese population (2011)
  • Author(s): M. Nakataki, J. Iga, S. Numata, E. Yoshimoto, K. Kodera, S. Watanabe, H. Song, S. Ueno, T
  • Journal Title: Neurosci Lett Volume: 489 Pages: 126-130
  • Peer Reviewed
• [Journal Article] Different actions for acute and chronic administration of mirtazapine on serotonergic transmission associated with raphe nuclei and their innervation cortical regions (2011)
  • Author(s): S. Yamamura, M. Abe, M. Nakagawa, S. Ochi, S. Ueno, M. Okada
  • Journal Title: Neuropharmacology Volume: 60 Pages: 550-560
  • Peer Reviewed
• [Journal Article] Mitochondrial DNA deletion mutations in patients with neuropsychiatric symptoms (2011)
  • Author(s): M. Kato, M. Nakamura, M. Ichiba, A. Tomiyasu, H. Shimo, I. Higuchi, S. Ueno, A. Sano
  • Journal Title: Neurosci Res Volume: 69(4) Pages: 331-336
  • Peer Reviewed
• [Journal Article] Clinical profiles of late-onset semantic dementia, compared with early-onset semantic dementia and late-onset Alzheimer's disease (2011)
  • Author(s): H. Shimizu,K. Komori, R Fukuhara,S. Shinagawa, Y. Toyota, T. Kashibayashi, N. Sonobe, T. Matsumoto, T. Mori, T. Ishikawa, K. Hokoishi, S. Tanimukai, S. Ueno, M. Ikeda
  • Journal Title: Psychogeriatrics Volume: 11 Pages: 46-53
  • Peer Reviewed
• [Journal Article] Pathogenic mutations and copy number variations in the VPS13A gene in patients with chorea-acanthocytosis (2011)
  • Author(s): A. Tomiyasu, M. Nakamura, M. Ichiba, S. Ueno, S. Saiki, M. Morimoto, J. Kobal, Y. Kageyama, T. Inui, K. Wakabayashi, T. Yamada, Y. Kanemori, H. H. Jung, H. Tanaka, S. Orimo, Z. Afawi, I. Blatt, J. Aasly, H. Ujike, D. Babovic-Vuksanovic, K. A. Josephs, R. Tohge, G. R. Rodrigues, N. Dupre, H. Yamada, F. Yokochi, K. Kotschet, T. Takei, M. Rudzinska, A. Szczudlik, S. Penco, M. Fujiwara, K. Tojo, A. Sano
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet Volume: 156B(5) Pages: 620-631
  • Peer Reviewed
• [Journal Article] 高気圧酸素療法治療中に鏡現象を呈した間歇型一酸化炭素中毒後遺症の一例 (2011)
  • Author(s): 清水秀明, 鉾石和彦, 福原竜治, 上野修一
  • Journal Title: 最新精神医学 Volume: 16 Pages: 349-353
  • Peer Reviewed
• [Presentation] Change of sleep habits and sleep problems across kindergarten, primary school, junior and senior high-school (2012)
  • Author(s): F. Horiuchi, Y. Oka, N. Takahashi, N. Takata, S. Tanno, Y. Kawasaki, E. Campos, K. Kawabe, T. Tanigawa, S. Ueno
  • Organizer: The International Pediatric Association Congress 2012
  • Place of Presentation: Manchester, England
• [Presentation] Relationship between sleep insufficiency and behavioral/ emotional problems (2012)
  • Author(s): F. Horiuchi, Y. Oka, N. Takata, N. Takahashi, S. Tanno, Y. Kawasaki, E. Campos, K. Kawabe, T. Tanigawa, S. Ueno
  • Organizer: The International Pediatric Association Congress 2012
  • Place of Presentation: Manchester, England
• [Presentation] Genetical and Clinical study of an Alzheimer's disease Family with Amyloid Precursor Protein (APP) V717L Mutation (2012)
  • Author(s): S. Ochi, M. Abe, Y. Mori, Y. Yoshino, T. Ishimaru, S. Matsuda, S. Ueno
  • Organizer: The Society for Neuroscience 2012
  • Place of Presentation: NewOrleans, USA
• [Presentation] Distribution of D- 3- amino isobutyrate-pyruvate aminotransferase in rat brain (2012)
  • Author(s): M. Abe, S. Ochi, Y. Mori, Y Yoshino, T. Ishimaru, S. Matsuda, S. Ueno
  • Organizer: The Society for Neuroscience 2012
  • Place of Presentation: NewOrleans, USA
• [Presentation] Two cases of Alzheimer's disease with persecutory delusion effectively improved by medication of paroxetine (2012)
  • Author(s): R. Fukuhara, T. Matsumoto, I. Kitamura, S. Ueno, M. Ikeda
  • Organizer: International Psychogeriatric Association International Meeting 2012
  • Place of Presentation: Cairns, Australia
• [Presentation] Different Actions for 21- Day Administration of Mirtazapine on Serotonergic Transmission Associated with Raphe Nuclei and their Innervation Cortical Regions (2011)
  • Author(s): M. Abe, S. Ochi, M. Okada, S. Ueno
  • Organizer: 2nd Congress Asian College of Neuropsychopharmacology
  • Place of Presentation: Seoul, Korea
• [Book] 幻覚と妄想 (2011)
  • Author(s): 福原竜治, 上野修一
  • Publisher: シナジー