| Project/Area Number |
23659570
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
YOSHIKAWA Takeo 独立行政法人理化学研究所, 分子精神科学研究チーム, チームリーダー (30249958)
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| Co-Investigator(Kenkyū-buntansha) |
MAEKAWA Motoko 独立行政法人理化学研究所, 分子精神科学研究チーム, 研究員 (50435731)
TOYOSHIMA Manabu 独立行政法人理化学研究所, 分子精神科学研究チーム, 基礎科学特別研究員 (90582750)
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| Research Collaborator |
岡野 栄之 慶応大学, 医学部生理学教室
赤松 和土 慶応大学, 医学部生理学教室
岡田 洋平 慶応大学, 医学部生理学教室
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 22q11.2欠失 / 統合失調症 / iPS cell / neurosphere / DGCR8 / let-7 family / 22q11.2欠乏症候群 / iPS細胞 / miRNA / 22q11.2欠失症候群 / 神経分化 |
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| Research Abstract |
We established iPS cells from two patients with 22q11.2 deletion and schizophrenia. Control iPS cells were from two normal subjects. We differentiated them into neurospheres (NS). Using these NS, we performed cDNA microarray analysis and found that DGCR8 gene, which is responsible for miRNA processing, is down-regulated in the NS from patients. Then we did miRNA chip analysis and revealed that the expressions of miRNAs relevant to differentiation from NS to neurons are dysregulated.
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