Study on volatile organic compounds associated with schizophrenia.

• Project/Area Number: 23659572
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: 公益財団法人東京都医学総合研究所 (2012); Tokyo Metropolitan Organization for Medical Research (2011)
• Principal Investigator: ITOKAWA Masanari 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 参事研究員 (40332324)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 精神薬理学 / 統合失調症 / 代謝分泌物質 / ビタミンB6 / カルボニルストレス

Research Abstract

We found a case with schizophrenia who is in pedigree with multiple affected individuals and had a frameshift mutation reducing enzymatic activity by 50% in glyoxalase1 gene. The case suggested possibility of carbonyl stress is involved in pathophysiology of schizophrenia and high plasma AGEs was detected in 46.7% of the patients. We studied on volatile organic compounds associated with schizophrenia to reveal pathophysiology of the disease(Arai et al. Arch Gen Psychiatry 2010). We detected volatile organic compounds contained in the air of the ward by using GCMS

Research Products

• [Journal Article] Paradox of Schizophrenia genetics: is a paradigm shift ocurring? (2012)
  • Author(s): Doi N, Hoshi Y, Itokawa M, Yoshikawa T, Ichikawa T, Arai M, Usui C, Tachikawa H
  • Journal Title: Behave Brain Funct Volume: 8(1) Pages: 28-28
  • Peer Reviewed
• [Journal Article] Association of SNPs linked to increased expression of SLC1A1 with schizophrenia (2012)
  • Author(s): Horiuchi Y, Iida S, Koga M, Ishiguro H, Iijima Y, Inada T, Watanabe Y, Someya T, Ujike H, Iwata N, Ozaki N, Kunugi H, Tochigi M, Itokawa M, Arai M, Niizato K, Iritani S, Kakita A, Takahashi H, Nawa H, Arinami T
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet Volume: 159B(1) Pages: 30-7
  • Peer Reviewed
• [Journal Article] Paradox of schizophrenia genetics: do we need a paradigm shift? (2012)
  • Author(s): Nagafumi Doi N, Yoko Hoshi, Masanari Itokawa, Takeo Yoshikawa, Tomoe Ichikawa, Chie Usui, Hirokazu Tachikawa
  • Journal Title: Behavioral and Brain Functions Volume: 8 Issue: 1 Pages: 28-28
  • DOI: 10.1186/1744-9081-8-28
  • Peer Reviewed
• [Journal Article] Association of SNPs linked to increased expression of SLC1A1 with schizophrenia (2012)
  • Author(s): Horiuchi Y, Iida S, Koga M, Ishiguro H, Iijima Y, Inada T, Watanabe Y, Someya T, Ujike H, Iwata N, Ozaki N, Kunugi H, Tochigi M, Itokawa M, Arai M, Niizato K, Iritani S, Kakita A, Takahashi H, Nawa H, Arinami T
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet Volume: 159 B Issue: 1 Pages: 30
  • DOI: 10.1002/ajmg.b.31249
  • URL: https://pure.teikyo.jp/en/publications/0fa6173e-8aca-454e-be68-1fb6ca2ab9da
  • Peer Reviewed
• [Journal Article] 精神疾患の新しい病態仮説：カルボニルストレス (2012)
  • Author(s): 新井誠, 糸川昌成.
  • Journal Title: 日薬雑誌 Volume: 139 Pages: 87-87
  • NAID: 10030456295
• [Journal Article] Positive association of Phencyclidine-responsive genes, PDE4A and PLAT,with schizophrenia (2011)
  • Author(s): Deng X, Takaki H, Wang L, Kuroki T, Nakahara T, Hashimoto K, Ninomiya H, Arinami T, Inada at, Ujike H, Itokawa M, Tochigi M, Watanabe Y, Someya T, Kunugi H, Iwata N, Ozaki N, Shibata H, Fukumaki Y
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet Volume: 156(7) Pages: 850-858
  • Peer Reviewed
• [Journal Article] Association analysis of the tryptophan hydroxylase 2 gene polymorphisms in patients with methamphetamine dependence/psychosis (2011)
  • Author(s): Kobayashi H, Ujike H, Iwata N, Inada T, Yamada M, Sekine Y, Uchimura N, Iyo M, Ozaki N, Itokawa M, Sora I
  • Journal Title: Curr Neuropharmacol Volume: 9(1) Pages: 137-142
  • Peer Reviewed
• [Journal Article] Schizophrenia with the 22q11.2 deletion and additional genetic defects: case history (2011)
  • Author(s): Toyosima M, Maekawa M, Toyota T, Iwayama Y, Arai M, Ichikawa T, Miyashita M, Arinami T, Itokawa M, Yoshikawa T
  • Journal Title: The British Journal of Psychiatry Volume: 199 Pages: 245-246
  • Peer Reviewed
• [Journal Article] Classification of First-Episode Schizophrenia Patients and Healthy Subjects by Automated MRI Measures of Regional Brain Volume and Cortical Thickness (2011)
  • Author(s): Takayanagi Y, Takahashi T, Orikabe L, Mozue Y, Kawasaki Y, Nakamura K, Sato Y, Itokawa M, Yamasue H, Kasai K, Kurachi M, Okazaki Y, Suzuki M
  • Journal Title: PLoS One Volume: 6(6)
  • Peer Reviewed
• [Journal Article] Positive association of phencyclidine-responsive genes, PDE4A and PLAT, with schizophrenia. (2011)
  • Author(s): Deng X, Takaki H, Wang L, Kuroki T, Nakahara T, Hashimoto K, Ninomiya H, Arinami T, Inada T, Ujike H, Itokawa M, et al.
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet. Volume: 156B(7) Pages: 850-858
  • Peer Reviewed
• [Journal Article] Association analysis of the tryptophan hydroxylase 2 gene polymorphisms in patients with methamphetamine dependence/psychosis. (2011)
  • Author(s): Kobayashi H, Ujike H, Iwata N, Inada T, Yamada M, Sekine Y, Uchimura N, Iyo M, Ozaki N, Itokawa M, *Sora I.
  • Journal Title: Curr Neuropharmacol Volume: 9(1) Pages: 137-142
  • Peer Reviewed
• [Journal Article] Schizophrenia with the 22q11.2 deletion and additional genetic defects: case history. (2011)
  • Author(s): Toyosima M, Maekawa M, Toyota T, Iwayama Y, Arai M, Ichikawa T, Miyashita M, Arinami T, Itokawa M, *Yoshikawa T.
  • Journal Title: The British Journal of Psychiatry Volume: 199 Pages: 245-246
  • Peer Reviewed
• [Journal Article] Classification of First-Episode Schizophrenia Patients and Healthy Subjects by Automated MRI Measures of Regional Brain Volume and Cortical Thickness. (2011)
  • Author(s): 1.Takayanagi Y, Takahashi T, Orikabe L, Mozue Y, Kawasaki Y, Nakamura K, Sato Y, Itokawa M, Yamasue H, Kasai K, Kurachi M, Okazaki Y, *Suzuki M.
  • Journal Title: PLoS One Volume: 6(6)
  • Peer Reviewed
• [Presentation] (招待講演) カルボニルストレス性統合失調症 (2013)
  • Author(s): 糸川昌成
  • Organizer: 第5回レドックス・ライフイノベーションシンポジウム
  • Place of Presentation: 川崎
  • Year and Date: 2013-03-07
• [Presentation] カルボニルストレス性統合失調症 (2013)
  • Author(s): 糸川昌成
  • Organizer: 第5回レドックス・ライフイノベーションシンポジウム
  • Place of Presentation: 川崎
  • Invited
• [Presentation] Research of mechanisms of glycation as pathophysiololgy of schizophrenia. (2012)
  • Author(s): Arai M, Ichikawa T, Miyashita M, Toriumi K, Okazaki Y, Yoshikawa T, Miyata T, Itokawa M, Naila Rabbani, Paul Thornalley.
  • Organizer: 11°International Symposium on the Maillard Reaction
  • Place of Presentation: Nance, France
• [Presentation] (招待講演) 日常臨床から研究テーマをどのように得るのか (2011)
  • Author(s): 糸川昌成
  • Organizer: 第107回日本精神神経学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2011-10-26
• [Presentation] (招待講演) イブニングセミナー臨床家がなぜ研究をするのか-日本人だからこそ発見できる統合失調症研究- (2011)
  • Author(s): 糸川昌成
  • Organizer: 第33回日本生物学的精神医学会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-21
• [Presentation] 臨床家がなぜ研究をするのか－日本人だからこそ発見できる統合失調症研究－. (2011)
  • Author(s): *糸川昌成.
  • Organizer: 第33回 日本生物学的精神医学会(招待講演)
  • Place of Presentation: 東京
• [Presentation] 日常臨床から研究テーマをどのように得るのか. (2011)
  • Author(s): *糸川昌成.
  • Organizer: 第107回 日本精神神経学会学術総会(招待講演)
  • Place of Presentation: 東京
• [Book] 「統合失調症」からの回復を早める本 (2013)
  • Author(s): 糸川昌成. (監修)
  • Publisher: 東京:株式会社法研
• [Book] 統合失調症からの回復が早まる本 (2013)
  • Author(s): 糸川昌成
  • Total Pages: 199
  • Publisher: 法研
• [Remarks]
  • URL: http://www.igakuken.or.jp/schizo-dep/