| Project/Area Number |
23659573
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
KUGE Yuji 北海道大学, アイソトープ総合センター, 教授 (70321958)
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| Co-Investigator(Kenkyū-buntansha) |
ZHAO Songji 北海道大学, 大学院・医学研究科, 教授 (80374239)
NISHIJIMA Ken-ichi 北海道大学, 大学院・医学研究科, 特任講師 (60364254)
川井 恵一 金沢大学, 保健学系, 教授 (30204663)
山下 篤 宮崎大学, 医学部, 助教 (90372797)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWAI Keiichi 金沢大学, 保健学系, 教授 (30204663)
YAMASHITA Atsushi 宮崎大学, 医学部, 助教 (90372797)
NISHIJIMA Ken-ichi 北海道大学, 大学院・医学研究科, 特任講師 (60364254)
SHIMIZU Youichi 北海道大学, アイソトープ総合センター, 助教 (90634212)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 放射線 / 核医学診断 / 動脈硬化 / 不安定プラーク / 組織因子 |
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| Research Abstract |
We performed several experiments to establish a new nuclear medicine technique for imaging unstable atherosclerotic plaques through specific detection of tissue factor (TF). Consequently, we obtained several new findings concerning: 1) synthesis methods of 18F-laveled biotin-derivative, 2) PET imaging protocols and TF expression levels in our rabbit model, 3) accumulation of anti-rabbit TF monoclonal antibody in atherosclerotic lesions, and 4) blood clearance of anti-rabbit TF monoclonal antibody. These findings provided important information to establish a new nuclear medicine technique for TF imaging.
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