| Project/Area Number |
23659574
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
TAMAKI Nagara 北海道大学, 大学院・医学研究科, 教授 (30171888)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHINAGA Keiichiro 北海道大学, 大学院・医学研究科, 特任教授 (30435961)
HATTORI Naoya 北海道大学, 大学院・医学研究科, 特任講師 (30568499)
NISHIJIMA Kenichi 北海道大学, 大学院・医学研究科, 特任講師 (60364254)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | MIBG / 交感神経機能 / 受容体機能 / 心筋交感神経機能 / PET / 心臓核医学 |
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| Research Abstract |
In order to facilitate understanding of cardiac ne uronal function, the parameters estimated by MIBG imaging was compared with qua ntitative presynaptic and postsynaptic functional parameters obtained by cardia c PET studies. MIBG myocardial uptake was closely correlated with presynaptic f unction estimated by PET. Regional myocardial analysis indicated that more homo genous distribution on PET presynaptic function than MIBG uptake. Furthermore, postsynaptic (receptor) function estimated by PET closely correlated with MIBG washout from the myocardium but not MIBG myocardial uptake. These comparative s tudies may help better understanding of variousmyocardial MIBG parameters.
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