| Project/Area Number |
23659576
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KANEKO Tsuyoshi 筑波大学, 医学医療系, 講師 (90510181)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 放射線腫瘍学 / 亜鉛ポルフィリン / 陽電子放出型同位体 / PET / がん画像診断 / 62Zn / ポルフィリン |
|---|
| Research Abstract |
To develop a new tracer for positron emission tomography imaging(PET), we newly synthesized 62Zn containing porphyrin derivatives which have been reported to be accumulated in neoplastic cells. We investigated the efficacy of our Zn-porphyrins for tumor-area diagnosis with cancer cell-transplanted mice. These tracers were accumulated in the tumor tissue, as well as the liver and the spleen: both organs play important role for heme metabolisms. According to these results, 62Zn-porphyrin is suggested to be one of candidates for a tumor tracer in PET imaging.
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