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Research of treatment planning technology combination withmicro-dosimetry and macro-dosimetry for particle radiotherapy

Research Project

Project/Area Number 23659577
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionUniversity of Tsukuba

Principal Investigator

KUMADA Hiroaki  筑波大学, 医学医療系, 准教授 (30354913)

Co-Investigator(Kenkyū-buntansha) SATO Tatsuhiko  日本原子力研究開発機構, 原子力基礎工学部門, 研究員 (30354707)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords治療計画システム / 放射線治療 / 中性子捕捉療法 / モンテカルロ法 / マイクロドシメトリ / 粒子線治療 / 線量評価 / シミュレーション工学 / 治療計画 / ホウ素中性子捕捉療法
Research Abstract

We performed research and development for fundamentaltechnology of treatment planning in particle therapy which can estimate equivalent dose using numerical simulation by combination with micro-dosimetry in cell level and treatment planning technology (Macro-dosimetry). A patent for the new technology has been applied based on the achievement. We have verified the technology in the work, and the verification results demonstrated that equivalent dose can be calculated in the treatment planning work with PHITS as a Monte-Carlo code by innovating the technology into PHITS.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (36 results)

All 2013 2012 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 1 results) Presentation (18 results) (of which Invited: 1 results) Book (3 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] つくば国際戦略総合特区における次世代がん治療(BNCT)の開発実用化プロジェクトについて2013

    • Author(s)
      熊田博明
    • Journal Title

      バイオサイエンスとインダストリー

      Volume: Vol.71(1) Pages: 63-66

    • NAID

      10031140307

    • Related Report
      2012 Final Research Report
  • [Journal Article] つくば国際戦略総合特区における次世代がん治療(BNCT)の開発実用化プロジェクトについて2013

    • Author(s)
      熊田博明
    • Journal Title

      バイオサイエンスとインダストリー

      Volume: 71 Pages: 63-66

    • NAID

      10031140307

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Cell survival faction estimation based on the probability densities of domain and cell nucleus specific energies using improved microdosimetric kinetic models2012

    • Author(s)
      T.Sato, Y. Furuwasa
    • Journal Title

      RADIATION RESEARCH

      Volume: 178 Pages: 341-356

    • Related Report
      2012 Final Research Report
  • [Journal Article] Project of development of the linac based NCT facility in University of Tsukuba2012

    • Author(s)
      H. Kumada, A. Matsumura, H. Sakurai, T. Sakae, M. Yoshioka, H. Matsumoto, H. Kobayashi, Y. Kiyanagi, T. Shibata, H. Nakashima
    • Journal Title

      Abstract of 15thInternational Congress on Neutron Capture Therapy

      Volume: 109

    • Related Report
      2012 Final Research Report
  • [Journal Article] Development of a new linac based neutron capture therapy devices in University of Tsukuba2012

    • Author(s)
      H. Kumada, A. Matsumura, H. Sakurai, T. Sakae, M. Yoshioka, H. Matsumoto, H. Kobayashi, Y. Kiyanagi, T. Shibata, H. Nakashima
    • Journal Title

      Proceedings of PTCOG51

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] 小林仁、松本浩、中島宏、鬼柳善明、J-PARC技術を応用した加速器ベース中性子捕捉療法用治療装置の開発2012

    • Author(s)
      熊田博明、松村明、櫻井英幸、栄武二、吉岡正
    • Journal Title

      医学物理-第103回日本医学物理学会報文集‐

      Volume: 32 Pages: 197-197

    • Related Report
      2012 Final Research Report
  • [Journal Article] 加速器中性子源によるBNCTの実現、医学物理2012

    • Author(s)
      熊田博明、松村明、櫻井英幸、栄武二、吉岡正和、小林仁、松本浩、鬼柳善明、平賀富士夫、柴田徳思、中島宏
    • Journal Title

      第104回日本医学物理学会報文集

      Volume: 32 Pages: 19-20

    • Related Report
      2012 Final Research Report
  • [Journal Article] Multistep lattice-Voxel method utilizing lattice function for Monte-Carlo treatment planning with pixel based voxel model2012

    • Author(s)
      H. Kumada, K. Saito, T. Nakamura, T. Sakae, H. Sakurai, A. Matsumura, K. Ono
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 69 Pages: 1866-1869

    • NAID

      120007137344

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Project of development of the linac based NCT facility in University of Tsukuba2012

    • Author(s)
      H. Kumada, A. Matsumura, H. Sakurai, T. Sakae, M. Yoshioka, H. Matsumoto, H. Kobayashi, Y. Kiyanagi, T. Shibata, H. Nakashima
    • Journal Title

      Abstract of 15th International Congress on Neutron Capture Therapy

      Volume: -

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Multistep lattice-Voxel method utilizing lattice function for Monte-Carlo treatment planning with pixel based voxel model2011

    • Author(s)
      H. Kumada, K. Saito, T. Nakamura, T. Sakae, H. Sakurai, A. Matsumura, K.Ono
    • Journal Title

      Applied Radiation and Isotopes

      Volume: Vol. 69 Pages: 1866-1869

    • NAID

      120007137344

    • Related Report
      2012 Final Research Report
  • [Journal Article] Development of the Efficient Modeling Method with Complicated Human Geometry for Monte-Carlo Treatment Planning System2011

    • Author(s)
      H. Kumada, K. Saito, T. Sakae, A. Matsumura, T. Nakamura, K. Ono
    • Journal Title

      Progress in NUCLEAR SCIENCE and TECHNOLOGY

      Volume: Vol.2 Pages: 226-231

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] Application of the Multi-Modal Monte-Carlo Treatment Planning System Combined with PHITS to Proton Radiotherapy2011

    • Author(s)
      H. Kumada, T. Sakae, K. Saito, T. Isobe, T. Hashimoto, H. Sakurai
    • Journal Title

      Progress in NUCLEAR SCIENCE and TECHNOLOGY

      Volume: Vol.2 Pages: 213-218

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 筑波大学の加速器計画の進捗状況2013

    • Author(s)
      熊田博明
    • Organizer
      京都大学原子炉実験所専門研究会
    • Place of Presentation
      熊取
    • Year and Date
      2013-02-16
    • Related Report
      2012 Final Research Report
  • [Presentation] がん治療のための中性子利用2013

    • Author(s)
      熊田博明
    • Organizer
      平成24年度日本原子力学会 北関東支部講演会
    • Year and Date
      2013-02-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 最先端医療機器・医工連携分のイノベーション‐がん治療に貢献2012

    • Author(s)
      熊田博明
    • Organizer
      首都圏北部4大学連合(4u)医工連携シンポジウム
    • Place of Presentation
      千代田区
    • Year and Date
      2012-12-07
    • Related Report
      2012 Final Research Report
  • [Presentation] 加速器中性子源によるBNCTの実現2012

    • Author(s)
      熊田博明、松村明、櫻井英幸、栄武二、吉岡正和、小林仁、松本浩、鬼柳善明、平賀富士夫、柴田徳思、中島宏
    • Organizer
      第104回日本医学物理学会学術大会
    • Place of Presentation
      つくば
    • Year and Date
      2012-09-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Project of development of the linac based NCT facility in University of Tsukuba2012

    • Author(s)
      H. Kumada, A. Matsumura, H. Sakurai, T. Sakae, M. Yoshioka, H. Matsumoto, H. Kobayashi, Y. Kiyanagi, T. Shibata, H. Nakashima
    • Organizer
      15thInternational Congress on Neutron Capture Therapy
    • Place of Presentation
      Tsukuba
    • Year and Date
      2012-09-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Development of a new linac based neutron capture therapy devices in University of Tsukuba2012

    • Author(s)
      H. Kumada, A.Matsumura, H. Sakurai, T. Sakae, M. Yoshioka, H. Matsumoto, H. Kobayashi, Y. Kiyanagi, T. Shibata, H. Nakashima
    • Organizer
      PTCOG51
    • Place of Presentation
      Seoul
    • Year and Date
      2012-05-10
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] J-PARC 技術を応用した加速器ベース中性子捕捉療法用治療装置の開発2012

    • Author(s)
      熊田博明、松村明、櫻井英幸、榮 武二、吉岡正和、小林仁、松本浩、中島宏、鬼柳善明
    • Organizer
      第103回日本医学物理学会学術大会
    • Place of Presentation
      横浜
    • Year and Date
      2012-04-14
    • Related Report
      2012 Final Research Report
  • [Presentation] ホウ素中性子捕捉療法の最前線2012

    • Author(s)
      熊田博明、松村明、櫻井英幸
    • Organizer
      日本薬学会第132回年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-30
    • Related Report
      2012 Final Research Report
  • [Presentation] J-PARC技術を応用した加速器BNCT治療装置の開発2012

    • Author(s)
      熊田博明、松村明、櫻井英幸、榮武二、吉岡正和、小林仁、松本浩、鬼柳善明、中島宏
    • Organizer
      平成23年度研究炉及び加速器中性子源を用いた中性子捕捉療法の高度化に関する研究会
    • Place of Presentation
      大阪
    • Year and Date
      2012-02-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Project of development of the linac based NCT facility in University of Tsukuba2012

    • Author(s)
      H. Kumada, A. Matsumura, H. Sakurai, T. Sakae, M. Yoshioka, H. Matsumoto, H. Kobayashi, Y. Kiyanagi, T. Shibata, H. Nakashima
    • Organizer
      15th International Congress on Neutron Capture Therapy
    • Place of Presentation
      つくば市
    • Related Report
      2012 Annual Research Report
  • [Presentation] J-PARC技術を応用した加速器ベース中性子捕捉療法用治療装置の開発2012

    • Author(s)
      熊田博明、松村明、櫻井英幸、栄武二、吉岡正和、小林仁、松本浩、中島宏、鬼柳善明
    • Organizer
      第103回日本医学物理学会学術大会
    • Place of Presentation
      横浜市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 加速器中性子源によるBNCTの実現2012

    • Author(s)
      熊田博明、松村明、櫻井英幸、栄武二、吉岡正和、小林仁、松本浩、鬼柳善明、平賀富士夫、柴田徳思、中島宏
    • Organizer
      第104回日本医学物理学会学術大会
    • Place of Presentation
      つくば市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] New Challenge for advanced BNCT in University of Tsukuba2011

    • Author(s)
      H. Kumada, A. Matsumura, H. Sakurai, T. Sakae, M. Yoshioka, H. Kobayashi, H. Matsumoto, Y. Kiyanagi, T. Shibata, H. Nakashima
    • Organizer
      6thYoung Researcher BNCT Meeting
    • Place of Presentation
      Taipei
    • Year and Date
      2011-12-08
    • Related Report
      2012 Final Research Report
  • [Presentation] J-PARC 加速器技術を応用した高強度中性子発生技術による加速器BNCT治療装置の開発2011

    • Author(s)
      熊田博明
    • Organizer
      日本放射線腫瘍学会第24回学術大会
    • Place of Presentation
      神戸
    • Year and Date
      2011-11-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Verification of performance of Monte-Carlo dose estimation by combination with the Multistep Lattice Voxel modeling method2011

    • Author(s)
      H. Kumada, T. Sakae, H. Sakurai, H. Horiguchi, T. Nakamura, K. Saito, A. Matsumura
    • Organizer
      第6回日韓医学物理学術合同大会
    • Place of Presentation
      博多
    • Year and Date
      2011-09-30
    • Related Report
      2012 Final Research Report
  • [Presentation] PHITSの放射線治療への応用2011

    • Author(s)
      熊田博明
    • Organizer
      平成23年度PHITS講演会
    • Place of Presentation
      東海村
    • Year and Date
      2011-08-23
    • Related Report
      2012 Final Research Report
  • [Presentation] モンテカルロ治療計画の粒子輸送計算を高速化するボクセルモデリング法の開発2011

    • Author(s)
      熊田博明、中村剛実、堀口洋徳、斎藤公明、榮武二、松村明
    • Organizer
      第101回医学物理学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-04-19
    • Related Report
      2012 Final Research Report
  • [Presentation] マイクロドジメトリはマイクロビームとブロードビーム実験を繋ぐ架け橋となれるか?2011

    • Author(s)
      佐藤達彦
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸
    • Related Report
      2011 Research-status Report
  • [Book] Treatment planning, Neutron Capture Therapy Principles and Applications2012

    • Author(s)
      W.A.G. Sauerwein, R. Moss, A. Wittig, Y. Nagakawa
    • Total Pages
      553
    • Publisher
      Springer
    • Related Report
      2012 Final Research Report
  • [Book] Neutron Capture Therapy Principles and Applications2012

    • Author(s)
      W.S.Kiger 3rd, H. Kumada, W.A.G. Sauerwein, R. Moss, A. Wittig, et al.
    • Publisher
      Springer
    • Related Report
      2012 Annual Research Report
  • [Book] BNCTの基礎から臨床応用まで ~BNCTを用いて治療にかかわる人のためのテキスト~2011

    • Author(s)
      (財)医用原子力技術研究振興財団
    • Total Pages
      166
    • Related Report
      2012 Final Research Report
  • [Remarks] 本研究を通して発明した手法について特許出願するための手続きを現在行っている。平成24年5月中に特許出願する予定である。

    • Related Report
      2011 Research-status Report
  • [Patent(Industrial Property Rights)] 情報処理装置、情報処理法及びプログラム2012

    • Inventor(s)
      佐藤達彦、熊田博明
    • Industrial Property Rights Holder
      日本原子力研究開発機構、筑波大学
    • Filing Date
      2012-05-31
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 情報処理装置、情報処理法及びプログラム2012

    • Inventor(s)
      佐藤達彦、熊田博明
    • Industrial Property Rights Holder
      佐藤達彦、熊田博明
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-124674
    • Filing Date
      2012-05-31
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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