| Project/Area Number |
23659578
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Mitsuaki 近畿大学, 農学部, 講師 (20433641)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 抗体 / 放射性同位元素 / 有機化学 |
|---|
| Research Abstract |
We planned to develop a novel chelating agent suitable for the prelabeling to establish a generic method for preparation radiolabeled antibodies. CHX-DTPA was selected as a chelate group, and then CHX-DTPA-Bn-Gly, which conjugated Gly via benzene ring attached to backbone carbon, was designed and synthesized. The chelating agent could be radiolabeled with indium-111 at low concentration, and it showed rapid urinary excretion. These results indicated that CHX-DTPA-Bn-Gly is a promising mother compound of the novel chelating agent.
|
