| Project/Area Number |
23659579
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Chiba University |
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Principal Investigator |
ARANO Yasushi 千葉大学, 大学院・薬学研究院, 教授 (90151167)
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| Co-Investigator(Kenkyū-buntansha) |
UEHARA Tomoya 千葉大学, 大学院・薬学研究院, 准教授 (10323403)
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| Co-Investigator(Renkei-kenkyūsha) |
HANAOKA Hirofumi 千葉大学, 大学院・薬学研究院, 助教 (50361390)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 分子イメージング / アイソトープ治療 / 抗体 / 比放射能 / 体内動態 / キャリアタンパク質 / SPECT |
|---|
| Research Abstract |
Radiolabeled antibodies have been applied to molecular imaging and targeted radionuclice therapy. Since radiolabeled antibodies are administered in the presence of a large amount of non-labeled antibodies, the non-radiolabeled antibodies would inhibit the target accumulation of the radiolabeled antibodies. In this study, a new method was developed to prepare <99m>^Tc-labeled antibodies of high specific activities utilizing <99m>^Tc complexation reaction. The <99m>^Tc-labeled antibodies exhibited similar biodistribution in the presence of albumin or antibody F(ab')_2 fragment, suggesting further studies are worth pursuing for molecular imaging and targeted radionuclides therapy.
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