| Project/Area Number |
23659592
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
FUJII Hirotada 札幌医科大学, 医療人育成センター, 教授 (70209013)
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| Co-Investigator(Kenkyū-buntansha) |
EMOTO Miho 札幌医科大学, 医療人育成センター, 研究員 (10578735)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 電子常磁性共鳴イメージング / ESR / EPR / イメージング / 複数分子 / 生理機能 |
|---|
| Research Abstract |
Electron paramagnetic resonance (EPR) imagingcombined with nitroxides is a powerful, noninvasive method for visualizing the redox status modulated by oxidative stress in vivo. However, to date, it has not always been possible to obtain three-dimensional (3D) images with a continuous wave (CW)-EPR imager in small rodents while using nitroxides. Due to improvements in imagers that enable rapid data-acquisition, the feasibility of 3D EPR imaging with good quality in mice was tested with nitroxides of different lipophilicities. Using thisimproved EPR imager,multiple molecular imaging studies were carried out in vivo.
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