Screening of radio-sensitizing phytochemicals and examination on their structures
| Project/Area Number |
23659593
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Ibaraki Prefectural University of Health Science |
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Principal Investigator |
OHNISHI Ken 茨城県立医療大学, 保健医療学部, 教授 (50152195)
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| Co-Investigator(Kenkyū-buntansha) |
HATANO Osamu 奈良県立医科大学, 医学部, 講師 (40164850)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 放射線増感 / フィトケミカル / フラボノイド / 放射線 / 癌 / 植物生理活性物質 / 増感剤 |
|---|
| Research Abstract |
We performed screening of about 40 kinds of flavonoid to find novel radiosensitizers derived from plants. From the screening, we found that 2 kinds of flavonoid enhance radiosensitivity of cancer cells and one of the flavonoids (Flavonoid A) has a stronger radiosensitization action to cancer cells compared with normal cells. Furthermore, it is suggested that apoptosis contributes to the radiosensitization. These results show that Flavonoid A is an efficacious radiosensitizer because of its faint cytotoxicity and preferential radiosensitization to cancer cells.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] siRNA Targeted for NBS1 enhances heat sensitivity in human anaplastic thyroid carcinoma cells2011
Author(s)
Okamoto N, Takahaski A, Ota I, Ohnishi K, Mori E, Kondo N, Noda T, Nakagawa Y, Uemura H, Yane K, Hosoi H, Ohnishi T
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Journal Title
International Journal of Hyperthermia
Volume: 27
Pages: 297-304
Related Report
Peer Reviewed
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[Journal Article] Repair pathways independent of the Fanconi anemia nuclear core complex play a predominant role in mitigating formaldehyde-induced DNA damage2011
Author(s)
Noda T, Takahashi A, Kondo N, Mori E, Okamoto N, Nakagawa Y, Ohnishi K, Zdzienicka, MZ, Thompson LH, Helleday T, Asada H, Ohnishi T
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Journal Title
Biochemical and Biophysical Research Communications
Volume: 404
Pages: 206-210
Related Report
Peer Reviewed
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[Journal Article] siRNA Targeted for NBS1 enhances heat sensitivity in human anaplastic thyroid carcinoma cells.2011
Author(s)
Okamoto N, Takahaski A, Ota I, Ohnishi K, Mori E, Kondo N, Noda T, Nakagawa Y, Uemura H, Yane K, Hosoi H, Ohnishi T
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Journal Title
International Journal of Hyperthermia
Volume: 27
Pages: 297-304
Related Report
Peer Reviewed
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