Depression mechanism of survival signals induced by radiation
| Project/Area Number |
23659594
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Nara Medical University |
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Principal Investigator |
ONISHI Takeo 奈良県立医科大学, 医学部, 特任教授 (60094554)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 放射線治療生物学 / 重粒子線 / 粒子線治療 / 細胞死シグナル / 生存シグナル / Akt |
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| Research Abstract |
Human gingival cancer cells (Ca9-22 cells) harboring mutated p53 (mp53) gene were irradiated with 2 Gy of X-rays or Fe-ion beams. Akt-related protein levels decreased when cells were irradiated with high LET radiation. In addition, high LET radiation increased G2/M phase arrests and suppressed the progression of the cell cycle much more efficiently when compared to low LET radiation. These results suggest that high LET radiation enhances apoptosis and cell cycle arrest by suppressing Akt-related signals,even in the cancer cells bearing mp53 gene.
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Report
(3 results)
Research Products
(84 results)
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[Journal Article] Depression of p53-independent Akt-survival signals in human oral cancer cells bearing mutatedp53 gene after exposure to high-LET radiation2012
Author(s)
Nakagawa, Y., A. Takahashi, A. Kajihara, N. Yamakawa, Y. Imai, I. Ota, N. Okamoto, E. Mori, T. Noda, Y. Furusawa, T. Kirita& T. Ohnishi
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Journal Title
Biochem Biophys Res Commun
Volume: 423(4)
Pages: 654-660
Related Report
Peer Reviewed
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[Journal Article] Depression of p53-independent Akt survival signals in human oral cancer cells bearing mutated p53 gene after exposure to high-LET radiation.2012
Author(s)
Yosuke Nakagawa,Akihisa Takahashi,Atsuhisa Kajihara,Nobuhiro Yamakawa,Yuichiro Imai,Ichiro Ota,Noritomo Okamoto,Eiichiro Mori,Taichi Noda,Yoshiya Furusawa,Tadaaki Kirita,Takeo Ohnishi
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 423 (4)
Issue: 4
Pages: 654-660
DOI
Related Report
Peer Reviewed
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[Journal Article] Frozen human cells can record radiation damage accumulated during space flight; mutation induction and radioadaptation2011
Author(s)
Yatagai, F., M. Honma, A. Takahashi, K. Omori, H. Suzuki, T. Shimazu, M. Seki, T. Hashizume, A. Ukai, K. Sugasawa, T. Abe, N. Dohmae, S. Enomoto, T. Ohnishi, A. Gordon & N. Ishioka
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Journal Title
Radiat. Environ. Biophys
Volume: 50(1)
Pages: 125-134
Related Report
Peer Reviewed
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[Journal Article] FANCD1/BRCA2 Plays Predominant Role in the Repair of DNA Damage Induced by ACNU or TMZ2011
Author(s)
Kondo, N., A. Takahashi, E. Mori, T. Noda, M. Z. Zdzienicka, L. H. Thompson, T. Helleday, M. Suzuki, Y. Kinashi, S. Masunaga, K. Ono, M. Hasegawa & T. Ohnishi
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Journal Title
PLoS One
Volume: 6(5)
Pages: 19659-19659
Related Report
Peer Reviewed
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[Journal Article] Repair pathways independent of the Fanconi anemia nuclear core complex play a predominant role in mitigating formaldehyde-induced DNA damage2011
Author(s)
Noda, T., A. Takahashi, N. Kondo, E. Mori, N. Okamoto, Y. Nakagawa, K. Ohnishi, M. Z. Zdzienicka, L. H. Thompson, T. Helleday, H. Asada & T. Ohnishi
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Journal Title
Biochem. Biophys. Res. Commun
Volume: 404(1)
Pages: 206-210
Related Report
Peer Reviewed
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[Presentation] FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ2011
Author(s)
Kondo, N., A. E. Takahashi, T. Mori, M. Noda, Z. Zdzienicka, L. H. Thompson, T. Helleday, M. Suzuki, Y. Kinashi, S. Masunaga, K. Ono, M. Hasegawa & T.Ohnishi
Organizer
14th Int. Conr. Radiat. Res
Place of Presentation
The Palace of Culture and Science, Warsaw, Poland
Year and Date
2011-08-30
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