| Project/Area Number |
23659599
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | National Defense Medical College |
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Principal Investigator |
SHINOMIYA NARIYOSHI 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 教授 (40505260)
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| Co-Investigator(Kenkyū-buntansha) |
MORIMOTO Yuji 防衛医科大学校, 医学教育部医学科専門課程, 准教授 (10449069)
AOKI Ichio 独立行政法人放射線医学総合研究, 所分子イメージング研究センター, チームリーダー (10319519)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 樹状細胞 / MRイメージング / がん / 造影剤 |
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| Research Abstract |
This study aimed to establish a non-invasive MR imaging technique for analyzing biodistribution of dendritic cells (DCs), which are known to play an important role in immunotherapy for cancer. Focusing on manganese as a new contrast agent, we synthesized a compound of manganese-chelate dextran (dex-Mn) and confirmed the agent was incorporated into DCs: however, it was not detected by MR imaging. Hence, we then synthesized a compound of gadolinium-chelate dextran (dex-Gd) and studied. As a result, dex-Gd-labeled DCs that were injected into mice footpads were visualized in the popliteal lymph nodes by TI-weighted MR imaging.
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