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Monitor of molecular-targeted cancer therapy using multimodal in vivo molecular imaging

Research Project

Project/Area Number 23659601
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionNational Cancer Center Japan

Principal Investigator

UMEDA Izumi  独立行政法人国立がん研究センター, 臨床開発センター, ユニット長 (40160791)

Co-Investigator(Renkei-kenkyūsha) KIMURA Sadaaki  独立行政法人国立がん研究センター, 臨床開発センター, 研究員 (10585029)
YAMAGUCHI Masayuki  独立行政法人国立がん研究センター, 臨床開発センター, ユニット長 (90450577)
YOSHINO Takayuki  独立行政法人国立がん研究センター, 東病院, 外来病棟医長 (20469969)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords分子イメージング / 分子標的薬 / 治療最適化 / 個別化医療
Research Abstract

To improve prediction of drug sensitivity, as well as optimization of cancer therapy through non-invasive imaging, we aimed at simultaneous visualization of drug-target interaction and drug efficacy. 1) Recently, new small molecules have been developed for treatment of EGFR-TKI resistant cancer, and we designed and synthesized new probes that allow the evaluation of their interaction to the intended target. 2) As indicators of the drug efficacy, we synthesized novel probes to visualize hypoxic tumor microenvironment. 3) To concurrently visualize the aforementioned events, we proceeded to develop simultaneous dual radionuclide imaging system.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (30 results)

All 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (25 results)

  • [Journal Article] In Vivo SPECT Imaging with 111In-DOTA-c(RGDfK) to Detect Early Pancreatic Cancer in a Hamster Pancreatic Carcinogenesis Model.2012

    • Author(s)
      Yoshimoto M, Hayakawa T, Mutoh M, Imai T, Tsuda K, Kimura S, Umeda IO, Fujii H, Wakabayashi K
    • Journal Title

      J Nucl Med

      Volume: 53(5) Issue: 5 Pages: 765-771

    • DOI

      10.2967/jnumed.111.099630

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo visualization of heterogeneous intra- tumoral distribution of hypoxia- inducible factor-1alpha activity by the fusion of high-resolution SPECT and morphological imaging tests.2012

    • Author(s)
      Fujii H, Yamaguchi M, Inoue K, Mutou Y, Ueda M, Saji H, Kizaka-Kondoh S, Moriyama N, Umeda IO
    • Journal Title

      J Biomed Biotechnol

      Volume: 2012(262741) Pages: 1-6

    • DOI

      10.1155/2012/262741

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] High resolution SPECT imaging for visualization of intratumoral heterogeneity using a SPECT/CT scanner dedicated for small animal imaging2012

    • Author(s)
      Umeda IO, Fujii H, et al
    • Journal Title

      Ann Nucl Med

      Volume: 26 Issue: 1 Pages: 67-76

    • DOI

      10.1007/s12149-011-0542-7

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthesis and evaluation of a novel ^<99m>Tc-labeled bioreductive probe for tumor hypoxia imaging2011

    • Author(s)
      Kimura S, Umeda I O, Moriyama N, Fujii H
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 21 (24) Pages: 7359-7362

    • URL

      http://dx.doi.org/10.1016/j.bmcl.2011.10.022

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and evaluation of a novel ^<99m>Tc-labeled bioreductive probe for tumor hypoxia imaging2011

    • Author(s)
      Kimura S, Fujii H, et al
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 21 Issue: 24 Pages: 7359-7362

    • DOI

      10.1016/j.bmcl.2011.10.022

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 分子標的薬耐性化の判定を目指した新規SPECTプローブの開発2013

    • Author(s)
      服部久範、梅田泉、木村禎亮、吉本光喜、藤井博史
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Development of RGD-liposomes for MR imaging of pancreatic tumor2012

    • Author(s)
      Mitsuyoshi Yoshimoto, Takuya Hayakawa, Masayuki Yamaguchi, Sadaaki Kimura, Izumi O. Umeda, Hirofumi Fujii
    • Organizer
      2012 World Molecular Imaging Congress
    • Place of Presentation
      Dubline, Ireland
    • Year and Date
      2012-09-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Quantitative Estimation of Activity with an Artificial Neural Network for Multi-isotope SPECT Study2012

    • Author(s)
      Koichi Ogawa, Shuko Abe, Yusuke Koike, Izumi O. Umeda, Hirofumi Fujii
    • Organizer
      2012 World Molecular Imaging Congress
    • Place of Presentation
      Dubline, Ireland
    • Year and Date
      2012-09-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Development of ^<111>In-labeled phosphatidylserine liposomes for detection of atherosclerotic plaques2012

    • Author(s)
      Mikako Ogawa, Izumi O. Umeda, Mutsumi Kosugi, Ayumi Kawai, Yasuhiro Magata
    • Organizer
      SNM 2012 annual meeting(米国核医学会議2012年年会)
    • Place of Presentation
      Miami, FL, US
    • Year and Date
      2012-06-12
    • Related Report
      2012 Final Research Report
  • [Presentation] A novel PET probe for tumor hypoxia imaging with excellent renal clearance2012

    • Author(s)
      Sadaaki Kimura, Takuya Kuriyama, Yoshiki Kojima, Izumi O. Umeda, Noriyuki Moriyama, Hirofumi Fujii
    • Organizer
      SNM 2012 annual meeting(米国核医学会議2012年年会)
    • Place of Presentation
      Miami, FL, US
    • Year and Date
      2012-06-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Estimation of True Activity with An Artificial Neural Network for Multiple Isotope SPECT Study2012

    • Author(s)
      Shuko Abe, Koichi Ogawa, Yusuke Koike, Izumi O. Umeda, Hirofumi Fujii
    • Organizer
      2012 World Congress on Medical Physics and Biomedical Engineering
    • Place of Presentation
      Beijing, China
    • Year and Date
      2012-05-30
    • Related Report
      2012 Final Research Report
  • [Presentation] in vivo NIR Fluorescence and Nuclear Medical Hybrid ioimaging by Using Er-Doped YPO4 Nanoparticles2012

    • Author(s)
      Rie Saitoh, Kosuke Tsuji, Ryota Yamazaki, Hiroshi Hyodo, Kohei Soga, Hidehiro Kishimoto, Izumi O. Umeda, Hirofumi Fujii
    • Organizer
      2012 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environmental Sciences (PT-BMES 2012)
    • Place of Presentation
      Hsinchu, Taiwan
    • Related Report
      2012 Annual Research Report
  • [Presentation] 腫瘍選択性の向上を目指した新規低酸素PETプローブの合成と評価2012

    • Author(s)
      栗山拓也、小島良紀、木村禎亮、梅田 泉、西谷 潔、小島周二、藤井博史
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(札幌)
    • Related Report
      2011 Research-status Report
  • [Presentation] 腫瘍内HIF-1α陽性領域可視化を目指したSPECTプローブの開発 -組織分布の経時的変化と腫瘍内分布の検討-2012

    • Author(s)
      柿島 祐,梅田 泉,木村禎亮,口丸高弘,近藤科江,谷中昭典,藤井博史
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(札幌)
    • Related Report
      2011 Research-status Report
  • [Presentation] 99mTcを用いた低酸素領域可視化SPECTプローブの開発2011

    • Author(s)
      木村禎亮、梅田 泉、藤井博史
    • Organizer
      第9回がんとハイポキシア研究会
    • Place of Presentation
      学習院大学(東京)
    • Related Report
      2011 Research-status Report
  • [Presentation] 化学発癌モデルを用いた111In-DOTAーc(RGDfK)による膵がんイメージング2011

    • Author(s)
      吉本光喜、早川拓也、津田啓介、梅田 泉、藤井博史、谷中昭典、若林敬二
    • Organizer
      第11回放射性医薬品・画像診断薬研究会
    • Place of Presentation
      京都テルサ(京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] 低酸素還元を利用した新規メタボリックトラップ型99m Tc標識プローブの合成と評価2011

    • Author(s)
      木村禎亮、梅田 泉、藤井博史
    • Organizer
      第11回放射性医薬品・画像診断薬研究会
    • Place of Presentation
      京都テルサ(京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] 投与後早期のイメージングが可能な新規低酸素PETプローブの開発

    • Author(s)
      木村禎亮,栗山拓也,小島良紀,梅田泉,藤井博史
    • Organizer
      第7 回日本分子イメージング学会総会・学術集会
    • Place of Presentation
      浜松
    • Related Report
      2012 Annual Research Report
  • [Presentation] Estimation of True Activity with An Artificial Neural Network for Multiple Isotope SPECT Study

    • Author(s)
      Shuko Abe, Koichi Ogawa, Yusuke Koike, Izumi O. Umeda, Hirofumi Fujii
    • Organizer
      2012 World Congress on Medical Physics and Biomedical Engineering
    • Place of Presentation
      Beijing, China
    • Related Report
      2012 Annual Research Report
  • [Presentation] A novel PET probe for tumor hypoxia imaging with excellent renal clearance

    • Author(s)
      Sadaaki Kimura, Takuya Kuriyama, Yoshiki Kojima, Izumi O. Umeda, Noriyuki Moriyama, Hirofumi Fujii
    • Organizer
      SNM 2012 annual meeting (米国核医学会議 2012年年会)
    • Place of Presentation
      Miami, FL, US
    • Related Report
      2012 Annual Research Report
  • [Presentation] Development of 111In-labeled phosphatidylserine liposomes for detection of atherosclerotic plaques

    • Author(s)
      Mikako Ogawa, Izumi O. Umeda, Mutsumi Kosugi, Ayumi Kawai, Yasuhiro Magata
    • Organizer
      SNM 2012 annual meeting (米国核医学会議2012年年会)
    • Place of Presentation
      Miami, FL, US
    • Related Report
      2012 Annual Research Report
  • [Presentation] 近赤外蛍光バイオイメージングと核医学画像診断のハイブリッドin vivoイメージングプローブの作製と評価

    • Author(s)
      齋藤梨絵,辻孝輔,山崎良太,兵藤宏,曽我公平,岸本英博,梅田泉,藤井博史
    • Organizer
      第21回日本バイオイメージング学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Development of RGD-liposomes for MR imaging of pancreatic tumor

    • Author(s)
      Mitsuyoshi Yoshimoto, Takuya Hyakawa, Masayuki Yamaguchi, Sadaaki Kimura, Izumi O. Umeda, Hirofumi Fujii
    • Organizer
      2012 World Molecular Imaging Congress
    • Place of Presentation
      Dubline, Ireland
    • Related Report
      2012 Annual Research Report
  • [Presentation] ハムスター化学発がんモデルを用いた111In-DOTA-c(RGDfK)による早期膵癌イメージング

    • Author(s)
      吉本光喜,早川拓也,武藤倫弘,今井俊夫,津田啓介,木村禎亮,梅田泉,藤井博史,若林敬二
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] 腫瘍内HIF-1α陽性領域可視化を目指した融合タンパク質POH-SPECTプローブの体内動態に関する検討

    • Author(s)
      柿島祐,梅田泉,木村禎亮,口丸高弘,近藤科江,田沼靖一,藤井博史
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] Tc-99mおよびIn-111同時データ収集におけるニューラルネットワークを用いたプライマリ光子の推定

    • Author(s)
      尾川浩一,小池悠介,梅田泉,藤井博史
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] 良好な体内動態を示す新規低酸素PETプローブの開発 ~18F-FMISOとの比較~

    • Author(s)
      木村禎亮,栗山拓也,小島良紀,服部久範,梅田泉,藤井博史
    • Organizer
      第10回がんとハイポキシア研究会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 小動物SPECT装置を用いて高い空間分解能で腫瘍内部を観る

    • Author(s)
      梅田泉
    • Organizer
      第8回インビボイメージング研究会
    • Place of Presentation
      柏
    • Related Report
      2012 Annual Research Report
  • [Presentation] 分子標的薬耐性化の判定を目指した新規SPECTプローブの開発

    • Author(s)
      服部久範,梅田泉,木村禎亮,吉本光喜,藤井博史
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規低酸素PETプローブ18F-FPINIの腫瘍内分布及び代謝物の解析

    • Author(s)
      木村禎亮,栗山拓也,小島良紀,梅田泉,藤井博史
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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