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The study of application of microRNA to radiation therapy

Research Project

Project/Area Number 23659603
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionNational Cancer Center Japan

Principal Investigator

ZENDA Sadamoto  独立行政法人国立がん研究センター, 臨床開発センター, 研究員 (30466198)

Co-Investigator(Kenkyū-buntansha) OMURA Motoko  横浜市立大学, 大学院・医学研究科, 客員准教授 (70244506)
HARA Takamitsu  福島県立医科大学, 医学部, 准教授 (70464542)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsmicroRNA / miRNA / 放射線感受性 / アポトーシス
Research Abstract

MicroRNA is the cellular RNA which was identified controlling expression of protein at a translation level in late years. There are many unknown parts about the function. However, some microRNAs about radiosensitivity of the cell are reported, and it is thought that new knowledge about the biological influence of the radiation may be provided if relations with microRNA and the radiosensitivity are analyzed in detail. It was thought that some microRNAs concerned radiosensitivity from the result of this study.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (10 results)

All 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Impact of early radiological response evaluation on radiotherapeutic outcomes in the patients with nasal cavity and paranasal sinus malignacies2012

    • Author(s)
      H. Hojo, S. Zenda, T. Akimoto, R. Kohno, M. Kawashima, S. Arahira, T. Nishio, M. Tahara, R. Hayashi, K. Sasai
    • Journal Title

      J. Radiat. Res.

      Volume: 53 Issue: 5 Pages: 704-709

    • DOI

      10.1093/jrr/rrs021

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of early radiological response evaluation on radiotherapeutic outcomes in the patients with nasal cavity and paranasal sinus malignancies.2012

    • Author(s)
      Hojo H.
    • Journal Title

      J Radiat Res.

      Volume: 53(5) Pages: 704-9

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Dermatitis Control Program (DeCoP) for head and neck cancer patients receiving radiotherapy: a prospective phase II study2012

    • Author(s)
      Sadamoto Zenda , Shinobu Ishi, et al.
    • Journal Title

      International Journal of Clinical Oncology

      Volume: in press Issue: 2 Pages: 350-355

    • DOI

      10.1007/s10147-012-0385-9

    • NAID

      10031176276

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multicenter phase II study of an opioid-based pain control program for head and neck cancer patients receiving chemoradiotherapy2011

    • Author(s)
      Zenda S, Matsuura K, Tachibana H, Homma A, Kirita T, Monden N, Iwae S, Ota Y, Akimoto T, Otsuru H, Tahara M, Kato K, Asai M
    • Journal Title

      Radiother Oncol

      Volume: 101 Issue: 3 Pages: 410-414

    • DOI

      10.1016/j.radonc.2011.09.016

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Proton Beam Therapy for Unresectable Malignancies of The Nasal Cavity and Paranasal Sinuses2011

    • Author(s)
      Sadmoto Zenda ,Takashi Ogino, et al.
    • Journal Title

      International Journal of Radiation Oncology Biology Physics

      Volume: 81(5) Issue: 5 Pages: 1473-1478

    • DOI

      10.1016/j.ijrobp.2010.08.009

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Proton Beam Therapy as a Nonsurgical Approach to Mucosal Melanoma of The Head and Neck: A Pilot Study2011

    • Author(s)
      Sadamoto Zenda , Mitsuhiko Kawashima , Takashi Ogino , et al.
    • Journal Title

      International Journal of Radiation Oncology Biology Physics

      Volume: 81(1) Issue: 1 Pages: 135-139

    • DOI

      10.1016/j.ijrobp.2010.04.071

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] ワークショップ頭頸部癌治療-最新の知見―2011

    • Author(s)
      全田貞幹
    • Organizer
      第36回日本外科系連合学会学術集会
    • Place of Presentation
      浦安
    • Related Report
      2012 Final Research Report
  • [Presentation] Proton Beam Therapy for Patients with Malignancies of The Nasal Cavity, Para-nasal Sinuses, and/or Involving The Skull Base2011

    • Author(s)
      S Zenda
    • Organizer
      The Analysis of Late Toxicity, American Society for Radiation Oncology(ASTRO)
    • Place of Presentation
      Miami
    • Related Report
      2012 Final Research Report
  • [Presentation] Proton Beam Therapy for Patients with Malignancies of The Nasal Cavity, Para-nasal Sinuses, and/or Involving The Skull base : The Analysis of Late Toxicity2011

    • Author(s)
      Sadamoto Zenda
    • Organizer
      American Society for Radiation Oncology
    • Place of Presentation
      Miami Beach, FLA, US
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.ncc.go.jp/jp/ncce/rcio/research/ptd/szenda.html

    • Related Report
      2012 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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