| Project/Area Number |
23659608
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | Asahikawa Medical College |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TANIGUCHI Masahiko 旭川医科大学, 医学部, 准教授 (30374333)
FUKAI Moto 北海道大学, 大学病院, 医員 (60374344)
MATSUBARA Kazuo 旭川医科大学, 医学部, 教授 (20127533)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
NISHIKAWA Yuji 旭川医科大学, 医学部, 教授 (90208166)
KARASAKI Hidenori 旭川医科大学, 医学部, 講師
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 移植外科学 / 灌流保存 / 心停止下移植 / 肝移植 / マージナルドナー / 臓器不足 / 心停止ドナー / 臓器保存 |
|---|
| Research Abstract |
We confirmed that the superiority of the novel solution over UW solution for the use of simple cold preservation in rat liver and heart, due to the inhibition of cytosolic Ca2+ overload and cytoskeletal breakdown, and stimulation of aerobic respiration. However, these beneficial effects were abolished in liver and kidney preservation and transplantation of the large animal models, due to insufficient perfusion, which is possibly attributed with high concentration of PEG. To proceed for clinical application, customization of PEG concentration should be explored. Perfusion preservation might be a solution for this problem. Thus, the model of liver perfusion preservation and transplantation in pigs has been established with resolving various technical problems.
|
