Development of perfusion preservation method of liver graft, aiming to clinical application for liver transplantation using non-heart-beating-donor
Project/Area Number |
23659608
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
General surgery
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Research Institution | Asahikawa Medical College |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
TANIGUCHI Masahiko 旭川医科大学, 医学部, 准教授 (30374333)
FUKAI Moto 北海道大学, 大学病院, 医員 (60374344)
MATSUBARA Kazuo 旭川医科大学, 医学部, 教授 (20127533)
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Co-Investigator(Renkei-kenkyūsha) |
NISHIKAWA Yuji 旭川医科大学, 医学部, 教授 (90208166)
KARASAKI Hidenori 旭川医科大学, 医学部, 講師
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 移植外科学 / 灌流保存 / 心停止下移植 / 肝移植 / マージナルドナー / 臓器不足 / 心停止ドナー / 臓器保存 |
Research Abstract |
We confirmed that the superiority of the novel solution over UW solution for the use of simple cold preservation in rat liver and heart, due to the inhibition of cytosolic Ca2+ overload and cytoskeletal breakdown, and stimulation of aerobic respiration. However, these beneficial effects were abolished in liver and kidney preservation and transplantation of the large animal models, due to insufficient perfusion, which is possibly attributed with high concentration of PEG. To proceed for clinical application, customization of PEG concentration should be explored. Perfusion preservation might be a solution for this problem. Thus, the model of liver perfusion preservation and transplantation in pigs has been established with resolving various technical problems.
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Report
(3 results)
Research Products
(63 results)
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[Journal Article] Does heavy water attenuate cold preservation and reperfusion injury in canine kidney?2012
Author(s)
Hirokata G, Fukai M, Wakayama K, Suzuki T, Taniguchi M, Yamashita K, Tahara M, Shibasaki S, Shimada S, Shimamura T, Hatanaka K, Taketomi A, and Todo S.
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Journal Title
Low Temperature Medicine
Volume: 38(3)
Pages: 62-68
Related Report
Peer Reviewed
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[Presentation] Heavy water confers protection against hepatic cold ischemia injury and hydrogen confers protection against hepatic reperfusion injury in isolated perfused rat liver2013
Author(s)
Shimada S, Fukai M, Wakayama K, Yamashita K, Taniguchi M, Suzuki T, Shimamura T, Kamiyama T, Furukawa H, Todo S, Taketomi A,
Organizer
The American Transplant Congress
Place of Presentation
Seattle, WA, USA
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[Presentation] ラット冷保存肝における再灌流時水素ガス投与の効果2012
Author(s)
島田慎吾 ,深井原 ,若山顕治, 山下健一郎,谷口雅彦,鈴木友己 ,嶋村剛 ,神山俊哉,古川博之,藤堂省 , 武冨紹信
Organizer
第39回日本臓器保存生物医学会
Place of Presentation
コラッセ福島
Related Report
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[Presentation] Hydrogen Sulfide Confers Protection Against Hepatic Warm Ischemia Reperfusion Injury in Mice2012
Author(s)
Shimada S, Fukai M, Yamashita K, Wakayama K, Kimura T, Fujiyoshi M, Suzuki T, Shimamura T, Kamiyama T, Taketomi A, and Todo S
Organizer
Annual Congress 24th International Congress of the Transplantation Society
Place of Presentation
Berlin Germany
Related Report
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[Presentation] 臓器の保存から修復への試み~ミトコンドリア機能と細胞内Ca2+ の重要性2011
Author(s)
深井原, 若山顕治, 山下健一郎, 福森大介, 廣方玄太郎、島田慎吾、芳賀早苗, 谷口雅彦, 嶋村剛, 鈴木友己, 尾崎倫孝, 松下通明, 古川博之, 藤堂省
Organizer
第38回日本臓器保存生物医学会学術集会
Place of Presentation
仙台
Year and Date
2011-11-23
Related Report
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[Presentation] ラット心冷保存・移植後のグラフト機能の評価2011
Author(s)
島田慎吾、深井原, 若山顕治, 山下健一郎, 福森大介, 廣方玄太郎, 芳賀早苗, 谷口雅彦, 嶋村剛, 鈴木友己, 尾崎倫孝, 松下通明, 古川博之, 藤堂省
Organizer
第38回日本臓器保存生物医学会学術集会
Place of Presentation
仙台
Year and Date
2011-11-23
Related Report
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