| Project/Area Number |
23659611
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
MATSUURA Nariaki 大阪大学, 医学(系)研究科(研究院), 教授 (70190402)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MORI Seiji 大阪大学, 大学院医学系研究科, 助教 (90467506)
濱田 吉之輔 大阪大学, 医学(系)研究科(研究院), 助教 (10362683)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HAMADA Yoshinosuke 大阪大学, 大学院医学系研究科, 特任助教 (10362683)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 血管新生 / マクロファージ / がん治療 / 血管申請 |
|---|
| Research Abstract |
DBP-maf (Vitamin D binding protein-macrophage activating factor) showed inhibitory activity for angiogenesis through suppressive effect on endothelial proliferation, adhesion activity to extracellular matrix proteins, migration capacity, and tube formation. DBP-maf inhibits markedly angiogenesis by Aorta ring assay, Das assay and Matrigel plague assay. Furthermore DBP-maf has stimulatory effect on macrophage activation. DBP-maf suppresses growth of hepatocellular carcinoma or pancreatic carcinoma cell lines in vivo.
|
