| Project/Area Number |
23659614
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
OHDAN Hideki 広島大学, 医歯薬保健学研究院, 教授 (10363061)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Yuka 広島大学, 医歯薬保健学研究院, 助教 (90432666)
ONOE Takashi 独立行政法人国立病院機構, 臨床研究部, 室長 (90549809)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 臓器移植 / 抗体関連拒絶反応 / B細胞 / CD1d / 血液型不適合 / Ｂ細胞 |
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| Research Abstract |
Antibodies produced through the activation of T cell-dependent B-2 cells and independent B-1 cells are now appreciated as important mediators of acute and chronic rejection. It is important to suppress sufficiently both type of B cell activation for improvement of allograft survival. However, the sensitivity of B-1/B-2 cell differentiation to various immunosuppressants still remained to be elucidated. To address this issue, in the present study, we have established in vitro and in vivo B cell activation models, in which the differentiation to B-1a, B-1b, and B-2 cells can be induced. By use of those models, we have evaluate the sensitivity and specificity of various immunosuppressive drugs and anti-CD1d antibody newly developed by us to B cell activation.
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