| Project/Area Number |
23659616
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
KATANO Mitsuo 九州大学, 医学(系)研究科(研究院), 教授 (10145203)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANO Kenji 九州大学, 先端融合医療レドックスナビ研究拠点, 教授 (00315061)
ONISHI Hideya 九州大学, 大学院医学研究院, 准教授 (30553276)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | がん細胞 / 細胞周期 / 細胞周期離脱 / 細胞周期再進入 / 低酸素 / G0期 / Smo / Hedgehogシグナル / 膵がん細胞 / Ｓｍｏ / 細胞周期再侵入 / 治療 |
|---|
| Research Abstract |
We have found that proliferation in pancreatic cancer cells under hypoxia is inhibited and that Hedgehog signaling is activated under hypoxia. Then we have provided the possibility that Hedgehog signaling may contribute to the mechanism of the re-entry into cell cycle from G0/G1 phase. To analyze this mechanism we have generated the hypoxia-resistant pancreatic cancer cell line and have confirmed that Hedgehog signaling, especially Smo molecule is involved in one of the mechanisms of re-entry into cell cycle from G0/G1 phase by reoxygenating this hypoxia-resistant cell line in vitro and in vivo experiments.
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