• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Liver regeneration using stem cells from hteeth (SHED) for congenital metabol

Research Project

Project/Area Number 23659618
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General surgery
Research InstitutionKyushu University

Principal Investigator

TAGUCHI Tomoaki  九州大学, 医学研究院, 教授 (20197247)

Co-Investigator(Kenkyū-buntansha) 野中 和明  九州大学, 歯学研究科(研究院), 教授 (90128067)
中山 功一  佐賀大学, 工学(系)研究科(研究院), 教授 (50420609)
大賀 正一  九州大学, 医学(系)研究科(研究院), 教授 (60233053)
山座 孝義  九州大学, 歯学研究科(研究院), 講師 (80304814)
山座 治義  九州大学, 歯学研究科(研究院), 講師 (30336151)
林田 真  九州大学, 大学病院, 助教 (70452761)
増本 幸二  筑波大学, 医学医療系, 教授 (20343329)
松浦 俊治  九州大学, 大学病院, 助教 (10532856)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords移植外科学 / 肝細胞移植 / 乳歯幹細胞 / 立体物 / 免疫寛容 / 先天性代謝異常症 / 先天性凝固異常症 / 肝移植 / 再生医療
Research Abstract

SHED was shown to have the character of MSC as well as HSC. SHED low expression of HLA. SHED was successfully induced to the hepatocyte-like cell in medium. These hepatocyte-like cells were settled to the damaged liver tissue in CCl4 induced liver chirrhosis as well as Wilson disease. These cells could compose the sphere structure. On the other hand, 3D liver structure was built using 3D bioprinter.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (29 results)

All 2013 2012 2011 Other

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (10 results) Book (2 results)

  • [Journal Article] A formula for determining the standard liver volume in children: a special reference for neonates and infants2012

    • Author(s)
      Saeki I, Tokunaga S, Matsuura T, Hayashida M, Yanagi Y, Taguchi T
    • Journal Title

      Pediatr Transplant

      Volume: 16 Issue: 3 Pages: 244-249

    • DOI

      10.1111/j.1399-3046.2011.01624.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relevance of HLA compatibility in living donor liver transplantation : the double-edged sword associated with the patient outcome2012

    • Author(s)
      Uchiyama H,Kayashima H, Matomo R,Shirabe K, Yoshizumi T, Ikegami T, Soejima Y, Matsuura T, Taguchi T, Maehara Y,
    • Journal Title

      Clin Transplant

      Volume: 26 Issue: 5

    • DOI

      10.1111/ctr.12019

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intracranial hemorrhage associated with vitamin K-deficiency bleeding in patients with biliary atresia : focus on long-term outcomes2012

    • Author(s)
      Alatas FS, Hayashida M, Matsuura T, Saeki I, Yanagi Y, Taguchi T
    • Journal Title

      J Pediatr Gastroenterol Nutr

      Volume: 54 Issue: 4 Pages: 52-57

    • DOI

      10.1097/mpg.0b013e3182421878

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A morphological study of the removed livers from patients receiving living donor liver transplantation for adult biliary atresia2012

    • Author(s)
      Matsuura T, Kohashi K, Yanagi Y, Saeki I, Hayashida M, Aishima S, Oda Y, Taguchi T
    • Journal Title

      Pediatr Surg Int

      Volume: 28 Issue: 12 Pages: 1171-1172

    • DOI

      10.1007/s00383-012-3183-6

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significance of abnormalities in systems proximal and distal to the obstructed site of duodenal atresia.2012

    • Author(s)
      Alatas FS, Masumoto K, Esumi G, Nagata K, Taguchi T
    • Journal Title

      J Pediatr Gastroenterol Nutr

      Volume: 54(2) Pages: 242-247

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The utility of muscle sparing axillar skin crease incision for pediatric thoracic surgery.2012

    • Author(s)
      Taguchi T, Nagata K, Kinoshita Y, Ieiri S, Tajiri T, Teshiba R, Esumi G, Karashima Y, Hoka S, Masumoto K
    • Journal Title

      Pediatr Surg Int

      Volume: 28 Pages: 239-244

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reduced-intensity conditioning in unrelated donor cord blood transplantation for patients with familial hemophagocytic lymphohistiocytosis.2012

    • Author(s)
      Nishi M, Nishimura R, Suzuki N, Sawada A, Okamura T, Fujita N, Kanai R, Yano J, Adachi S, Yasumi T, Sato E, Yasutomo K, Ishii E, Ohga S
    • Journal Title

      Am J Hematol

      Volume: in press

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acute liver failure as the initial manifestation of Wilson disease trigerred by human parvovirus B19 infection.2012

    • Author(s)
      Shiraishi A, Hoshina T, Ihara K, Doi T, Ohga S, Hara T
    • Journal Title

      Pediatr Infect Dis J

      Volume: 31(1) Pages: 103-104

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 臀部血管腫に伴うKasabach-Merritt症候群を疑われた新生児プロテインC欠損症の1例2012

    • Author(s)
      松永 友佳, 山本 順子, 大賀 正一, 横田 千恵, 高橋 保彦, 末延 聡一, 浦田 美秩代, 栢森 裕三, 康 東天, 原 寿郎
    • Journal Title

      日本小児皮膚科学会雑誌

      Volume: 印刷中

    • NAID

      10030291673

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Complete immunotolerance induction after FEIBA prophylaxis in a hemophilia A patient with high-titer inhibitor.2012

    • Author(s)
      Nanishi E, Ohga S, Doi T, Ishimura M, Ihara K, Takada H, Shima M, Hara T
    • Journal Title

      Haemophilia

      Volume: in press

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neonatal asphyxia and renal failure as the presentation of severe protein C deficiency.2012

    • Author(s)
      Matsunaga Y, Ohga S, Kinjo T, Ochiai M, Fukumoto Y, Ito N, Doi T, Kang D, Hara T
    • Journal Title

      J Perinatol

      Volume: in press

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hedgehog signaling pathway mediates the progression of non-invasive breast cancer to invasive breast cancer.2011

    • Author(s)
      Souzaki M, Kubo M, Kai M, Kameda C, Tanaka H, Taguchi T, Tanaka M, Onishi
    • Journal Title

      Cancer Sci

      Volume: 10(2) Pages: 373-381

    • NAID

      10029290080

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sessile serrated adenoma with early neoplastic progression: a clinicopathologic and molecular study.2011

    • Author(s)
      Fujita K, Yamamoto H, Matsumoto T, Hirahashi M, Gushima M, Kishimoto J, Nishiyama K, Taguchi T, Yao T, Oda Y
    • Journal Title

      Am J Surg Pathol

      Volume: 35(2) Pages: 295-304

    • NAID

      120004951575

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Correlation between the Number of segmental chromosome aberrations and the age at diagnosis of diploid neuroblastomas without MYCN amplification.2011

    • Author(s)
      Sozaki R, Tajiri T, Teshiba R, Kinoshita Y, Yosue R, Kohashi K, Oda Y, Taguchi T
    • Journal Title

      Journal of Pediatric Surgery

      Volume: 46 Pages: 2228-2232

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Outcome of modified portal vein anastomosis for recipients with portal vein thrombosis or stenosisi before living donor liver transplantation.2011

    • Author(s)
      Matsuura T, Yanagi Y, Saeki I, Hayashida M, Taguchi T
    • Journal Title

      Journal of Pediatric Surgery

      Volume: 46 Pages: 2291-2295

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Serum prohepcidin concentrations at birth and one month after birth in premature infants.2011

    • Author(s)
      Kitajima J, Ohga S, Kinjo T, Ochiai M, Takahata Y, Honjo S, Hara T
    • Journal Title

      Pediatric Blood & Cancer

      Volume: 56(2) Pages: 267-272

    • NAID

      10026710614

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Potent induction of IFN-γ production from cord blood NK cells by the stimulation with single-strand RNA.2011

    • Author(s)
      Eljaafari FM, Takada H, Tanaka T, Doi T, Ohga S, Hara T
    • Journal Title

      J Clin Immunol

      Volume: 31(4) Pages: 728-735

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] バイオラピッドプロトタイピングシステム(BRP system)を用いた機能的三次元肝構造体の構築2013

    • Author(s)
      柳佑典、中山功一、田村忠士、田口智章
    • Organizer
      第12回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] バイオラピッドプロトタイピングシステム(BRP system)を用いた立体的肝細胞構造体の構築2012

    • Author(s)
      栁佑典、林田真、田村忠士、所村正晴、中山功一、田口智章
    • Organizer
      第48回日本移植学会総会
    • Place of Presentation
      愛知
    • Related Report
      2012 Annual Research Report
  • [Presentation] 頭蓋内出血で発症した非症候性肝内胆管低形成症の一例2012

    • Author(s)
      林田真、栁佑典、鹿毛政義、入戸野博、田口智章
    • Organizer
      第39回日本小児栄養消化器肝臓学会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] Transplantation Eraにおける胆道閉鎖症の予後~A Single-Center Experiences~2012

    • Author(s)
      林田真、栁佑典、池上徹、吉住朋晴、副島雄二、調憲、前原善彦、田口智章
    • Organizer
      第30回日本肝移植研究会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] Trans-differentiation capacity into hepatocyte-like cells of stem cells fromhuman exfoliated deciduous teeth2012

    • Author(s)
      Alatas FS, Yamaza T, Yamaza H, Hayashida M, Yanagi Y, KukitaT, Nonaka K, Ohga S, Taguchi T
    • Organizer
      PAPS2012
    • Place of Presentation
      中国
    • Related Report
      2012 Annual Research Report
  • [Presentation] The Outcome of Biliary Atresia in Transplantation Era:A Single-Center Experience2012

    • Author(s)
      Hayashida M, Matsuura T, Saeki I, Yanagi Y, Taguchi T
    • Organizer
      PAPS2012
    • Place of Presentation
      中国
    • Related Report
      2012 Annual Research Report
  • [Presentation] 脳死肝臓移植希望レシピエント選択基準の現状と問題点2012

    • Author(s)
      林田真、栁佑典、田口智章
    • Organizer
      第49回日本小児外科学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] Trans-differentiation capacity into hepatocyte-like cells of stem cells from human exfoliated deciduous teeth2012

    • Author(s)
      Alatas FS, Yamaza T, Yamaza H, Hayashida M, Yanagi Y, Kukita T, Nonaka K, Ohga S, Taguchi T
    • Organizer
      第49回日本小児外科学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] バイオラピッドプロトタイピングシステム(BRP system)を用いた肝組織再構築の試み

    • Author(s)
      栁佑典、林田真、江角元史郎、中山功一、田口智章
    • Organizer
      第39回日本胆道閉鎖症研究会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] Trans-differentiation and spheroid formation of hepatocyte-like cells of stem cells from human exfoliated deciduous teeth ~ A New treatment tool for coagulopathy and metabolic disease ~

    • Author(s)
      Alatas FS, Yamaza T, Yamaza H, Hayashida M, Yanagi Y, Kukita T, Nonaka K, Ohga S, Taguchi T
    • Organizer
      The Twenty-third FUKUOKA International Symposium on Pediatric / Maternal-Child health research
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Book] スタンダード小児外科手術2013

    • Author(s)
      田口智章、他
    • Publisher
      メジカルビュー社
    • Related Report
      2012 Annual Research Report
  • [Book] 標準小児外科学2012

    • Author(s)
      田口智章、他
    • Publisher
      医学書院
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi