Liver regeneration using stem cells from hteeth (SHED) for congenital metabol
| Project/Area Number |
23659618
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
野中 和明 九州大学, 歯学研究科(研究院), 教授 (90128067)
中山 功一 佐賀大学, 工学(系)研究科(研究院), 教授 (50420609)
大賀 正一 九州大学, 医学(系)研究科(研究院), 教授 (60233053)
山座 孝義 九州大学, 歯学研究科(研究院), 講師 (80304814)
山座 治義 九州大学, 歯学研究科(研究院), 講師 (30336151)
林田 真 九州大学, 大学病院, 助教 (70452761)
増本 幸二 筑波大学, 医学医療系, 教授 (20343329)
松浦 俊治 九州大学, 大学病院, 助教 (10532856)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 移植外科学 / 肝細胞移植 / 乳歯幹細胞 / 立体物 / 免疫寛容 / 先天性代謝異常症 / 先天性凝固異常症 / 肝移植 / 再生医療 |
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| Research Abstract |
SHED was shown to have the character of MSC as well as HSC. SHED low expression of HLA. SHED was successfully induced to the hepatocyte-like cell in medium. These hepatocyte-like cells were settled to the damaged liver tissue in CCl4 induced liver chirrhosis as well as Wilson disease. These cells could compose the sphere structure. On the other hand, 3D liver structure was built using 3D bioprinter.
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] Relevance of HLA compatibility in living donor liver transplantation : the double-edged sword associated with the patient outcome2012
Author(s)
Uchiyama H,Kayashima H, Matomo R,Shirabe K, Yoshizumi T, Ikegami T, Soejima Y, Matsuura T, Taguchi T, Maehara Y,
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Journal Title
Clin Transplant
Volume: 26
Issue: 5
DOI
Related Report
Peer Reviewed
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[Journal Article] Reduced-intensity conditioning in unrelated donor cord blood transplantation for patients with familial hemophagocytic lymphohistiocytosis.2012
Author(s)
Nishi M, Nishimura R, Suzuki N, Sawada A, Okamura T, Fujita N, Kanai R, Yano J, Adachi S, Yasumi T, Sato E, Yasutomo K, Ishii E, Ohga S
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Journal Title
Am J Hematol
Volume: in press
Related Report
Peer Reviewed
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