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Development of the novel therapeutic methods for diabetes using pig's tissue-derived cells.

Research Project

Project/Area Number 23659623
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General surgery
Research InstitutionJichi Medical University

Principal Investigator

TERATANI TAKUMI  自治医科大学, 医学部, 講師 (70373404)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Eiji  自治医科大学, 医学部, 客員教授 (00245044)
FUJIMOTO Yashuhiro  京都大学, 医学(系)研究科(研究院), 助教 (80335281)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords再生医療 / 間葉系幹細胞 / 糖尿病 / 細胞移植 / iPS細胞
Research Abstract

Pancreatic islet transplantation as a promising treatment for type 1 diabetes has received widespread attention. However, condition of isolated-islet, yield and quality, are collected and considered to determine whether the organ can be used for clinical islet transplantation. In this study, may be able to restore the condition of isolated islets after transportation or preservation, and may help to improve the long-term outcome of islet transplantation.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (28 results)

All 2013 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (17 results) Remarks (7 results)

  • [Journal Article] Use of mesenchymal stem cell-conditioned medium to activate islets in preservation solution2013

    • Author(s)
      Kasahara N, Teratani T, Doi J, Iijima Y, Maeda M, Uemoto S, Fujimoto Y, Sata N, Yasuda Y, Kobayashi E
    • Journal Title

      Cell Med

      Volume: 5 Issue: 2-3 Pages: 75-81

    • DOI

      10.3727/215517913x666477

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Use of Mesenchymal Stem Cell-conditioned Medium to Activate Islets in Preservation Solution2013

    • Author(s)
      Kasahara N, Teratani T, Doi J, Iijima Y, Maeda M, Uemoto S, Fujimoto Y, Sata N, Yasuda Y, Kobayashi E.
    • Journal Title

      Cell Medicine

      Volume: 5 Pages: 1-8

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Islets From Rats and Pigs Transgenic for Photogenic Proteins2012

    • Author(s)
      Teratani T, Matsunari H, Kasahara N, Nagashima H, Kawarasaki T, Kobayashi E
    • Journal Title

      Curr Diabetes Rev

      Volume: 8(5) Issue: 5 Pages: 382-389

    • DOI

      10.2174/157339912802083504

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Islets from rats and pigs transgenic for photogenic proteins.2012

    • Author(s)
      Teratani T, Matsunari H, Kasahara N, Nagashima H, Kawarasaki T, Kobayashi E.
    • Journal Title

      Curr Diabetes Rev.

      Volume: 8 Pages: 382-389

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 劣化膵島の再生-MSC を用いた克服に向けて2013

    • Author(s)
      寺谷 工・笠原尚哉・土井淳司・藤本康弘・上本伸二・後藤昌史・小林英司
    • Organizer
      第40回日本膵・膵島移植研究会
    • Place of Presentation
      高松
    • Related Report
      2013 Final Research Report
  • [Presentation] 膵島の賦活化因子の探索2013

    • Author(s)
      寺谷 工・笠原尚哉・土井淳司・藤本康弘・上本伸二・小林英司
    • Organizer
      第40回日本膵・膵島移植研究会
    • Place of Presentation
      高松
    • Related Report
      2013 Final Research Report
  • [Presentation] 劣化膵島の蘇生法に対する革新的技術2013

    • Author(s)
      寺谷 工・藤本康弘・上本伸二・後藤昌史・小林英司
    • Organizer
      第39回日本移植学会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 間葉系幹細胞分泌因子を用いた臓器保存の新しい試み2013

    • Author(s)
      寺谷 工・笠原尚哉・藤本康弘・上本伸二・後藤昌史・小林英司
    • Organizer
      第40回日本臓器保存生物医学会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 間葉系幹細胞分泌因子を用いた臓器保存の新しい試み2013

    • Author(s)
      寺谷 工、笠原尚哉、藤本康弘、上本伸二、後藤昌史、小林英司
    • Organizer
      日本臓器保存生物医学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 膵島の賦活化因子の探索2013

    • Author(s)
      寺谷 工
    • Organizer
      日本膵・膵島移植研究会
    • Place of Presentation
      高松
    • Related Report
      2012 Research-status Report
  • [Presentation] 劣化膵島の再生-MSCを用いた克服に向けて2013

    • Author(s)
      寺谷 工
    • Organizer
      日本膵・膵島移植研究会
    • Place of Presentation
      高松
    • Related Report
      2012 Research-status Report
  • [Presentation] MSCを用いた劣化膵島の機能回復システムの開発2012

    • Author(s)
      寺谷 工・笠原尚哉・土井淳司・藤本康弘・上本伸二・後藤昌史・小林英司
    • Organizer
      第39回日本膵・膵島移植研究会
    • Place of Presentation
      旭川
    • Related Report
      2013 Final Research Report
  • [Presentation] 脂肪由来間葉系幹細胞を用いた凍結傷害膵島の賦活効果2012

    • Author(s)
      笠原尚哉・寺谷 工・土井淳司・藤本康弘・上本伸二・佐田尚宏・安田是和・小林英司
    • Organizer
      第39回日本膵・膵島移植研究会
    • Place of Presentation
      旭川
    • Related Report
      2013 Final Research Report
  • [Presentation] MSCを用いた劣化膵島の機能回復システムの開発2012

    • Author(s)
      寺谷 工
    • Organizer
      第39回 日本膵・膵島移植研究会
    • Place of Presentation
      北海道・旭川
    • Related Report
      2011 Research-status Report
  • [Presentation] 膵島移植における新しい治療戦略2011

    • Author(s)
      寺谷 工・笠原尚哉・上本伸二・藤本康弘・小林英司
    • Organizer
      第47回日本移植学会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] 凍結保存膵島の臨床応用化を目指した新しい移植法2011

    • Author(s)
      笠原尚哉・寺谷 工・根岸幸司・岩崎純治・金澤寛之・佐田尚宏・上本伸二・藤本康弘・小林英司
    • Organizer
      第111回日本外科学会
    • Place of Presentation
      紙面開催
    • Related Report
      2013 Final Research Report
  • [Presentation] Cell-transplantation therapy of the aggregation-free infusion solution with mesenchymal stem cells2011

    • Author(s)
      Takumi Teratani・Naoya Kasahara・Shinji Uemoto ・Yasuhiro Fujimoto ・Eiji Kobayashi
    • Organizer
      CTS-IXA 2011
    • Place of Presentation
      マイアミ
    • Related Report
      2013 Final Research Report
  • [Presentation] 分離膵島の新規輸送液の開発2011

    • Author(s)
      寺谷 工・笠原尚哉・藤本康弘・上本伸二・小林英司
    • Organizer
      第38回日本臓器保存生物医学会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] 膵島移植における新しい治療戦略2011

    • Author(s)
      寺谷 工
    • Organizer
      第47回 日本移植学会
    • Place of Presentation
      宮城県・仙台
    • Related Report
      2011 Research-status Report
  • [Presentation] Cell-transplantation therapy of the aggregation-free infusion solution with mesenchymal stem cells2011

    • Author(s)
      寺谷 工
    • Organizer
      CTS-IXA 2011
    • Place of Presentation
      アメリカ・マイアミ
    • Related Report
      2011 Research-status Report
  • [Presentation] 分離膵島の新規輸送液の開発2011

    • Author(s)
      寺谷 工
    • Organizer
      第38回 日本臓器保存生物医学会
    • Place of Presentation
      宮城県・仙台
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.jichi.ac.jp/cdamt/index.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 自治医科大学webページ

    • URL

      http://www.jichi.ac.jp

    • Related Report
      2013 Annual Research Report
  • [Remarks] 先端医療技術開発センター

    • URL

      http://www.jichi.ac.jp/cdamt/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 自治医科大学webページ

    • URL

      http://www.jichi.ac.jp/

    • Related Report
      2012 Research-status Report
  • [Remarks] 先端治療開発部門webページ

    • URL

      http://www.jichi.ac.jp/ddat/top.htm

    • Related Report
      2012 Research-status Report
  • [Remarks] 「自治医科大学webページ」

    • URL

      http://www.jichi.ac.jp/

    • Related Report
      2011 Research-status Report
  • [Remarks] 「先端治療開発部門webページ」

    • URL

      http://www.jichi.ac.jp/ddat/top.htm

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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