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Formation of insulin-producing cells from iPS cells in conjunction with islet transplantation

Research Project

Project/Area Number 23659627
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General surgery
Research InstitutionFukuoka University

Principal Investigator

YASUNAMI Yohichi  福岡大学, 医学部, 教授 (00166521)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords移植外科学 / インスリン産生細胞 / iPS細胞 / インスリン / 膵島移植 / 糖尿病 / 再生医療
Research Abstract

In this study, we attempted to generate insulin-producing cells from mouse iPS cells by co-transplantation with isolated islets (rat, porcine) beneath the kidney capsule of STZ-diabetic nude mice since islets may serve to provide an appropriate circumstances as “nitch”. As a result, clusters of insulin producing cells were found in tumors at 30 days after transplantation. Currently, the study with the use of iPS cells transfected with transcription factors including Pdx1, Ngn3 and MafA) is under investigation.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (9 results)

All 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Pretreatment of donor islets with the Na+/Ca2+ exchanger inhibitor improves the efficiency of islet transplantation.2013

    • Author(s)
      Mera T, Itoh T, Kita S, Kodama S, Kojima D, Nishinakamura H, Okamoto K, Ohkura M, Nakai J, Iyoda T, Iwamoto T, Matsuda T, Baba A, Omori K, Ono J, Watarai H, Taniguchi M, Yasunami Y.
    • Journal Title

      Am J Transplant

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevention of High-Mobility Group Box 1-Mediated Early Loss of Transplanted Mouse Islets in the Liver by Antithrombin III.2012

    • Author(s)
      Kojima D, Mera T, Nishinakamura H, Itoh T, Ogata T, Matsuoka N, Kodama S, Yasunami Y.
    • Journal Title

      Transplantation

      Volume: 93(10) Issue: 10 Pages: 983-8

    • DOI

      10.1097/tp.0b013e31824d3508

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevention of High-Mobility Group Box 1-Mediated Early Loss of Transplanted Mouse Islets in the Liver by Antithrombin III2012

    • Author(s)
      Kojima D, Mera T, Nishinakamura H, Itoh T, Ogata T, Matsuoka N, Kodama S, Yasunami Y.
    • Journal Title

      Transplantation

      Volume: In press

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 糖尿病の新しい治療としての膵島細胞移植2011

    • Author(s)
      安波洋一
    • Journal Title

      九州実験動物雑誌

      Volume: 27 Pages: 23-26

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 膵島移植とHMGB12011

    • Author(s)
      安波洋一
    • Journal Title

      バイオメヂカル

      Volume: 21 Pages: 42-46

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Inhibitory effect of thrombomodulin on HMGB1-stimulated IFN-γ production of hepatic NKT and Gr-1+ Cells, facilitating to prevent early loss of transplanted islets in the liver of mice.2012

    • Author(s)
      Kojima D, Nishinakamura H, Ogata T, Nagaishi M, Mera T, Itoh T, Matsuoka N, Kodama S, Yasunami Y.
    • Organizer
      24th International Congress of the Transplantation society
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2012 Annual Research Report
  • [Presentation] Innate immunity in Transplantation2011

    • Author(s)
      安波洋一
    • Organizer
      The 2011 Fall Conference of the Korean Association of Immunologists(招待講演)
    • Place of Presentation
      Seoul
    • Related Report
      2011 Research-status Report
  • [Presentation] Targeting HMGB1 in Transplantation2011

    • Author(s)
      安波洋一
    • Organizer
      3rd HMGB1 International Worshop(招待講演)
    • Place of Presentation
      Pittsburgh, USA
    • Related Report
      2011 Research-status Report
  • [Remarks] グローバルFUプログラムホームページ

    • URL

      http://www.med.fukuoka-u.ac.jp/globalfu/

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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