| Project/Area Number |
23659632
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIRANO Satoshi 北海道大学, 大学院・医学研究科, 教授 (50322813)
NAKAMURA Toru 北海道大学, 大学院・医学研究科, 助教 (70645796)
宮本 正樹 北海道大学, 大学病院, 助教 (40333611)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | TMA解析 / 胆道癌 / マーカー / 抗癌剤 / 免疫原性増強 / ＨＬＡ / classI発現増強 / 食道癌術前化学療法 / Immunogenic cell death |
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| Research Abstract |
We investigated the immune responses induced by neoadjuvant chemotherapy in esophageal cance and pancreatic cancer and clarified the increase of the CD4,CD8,CD45RO positive lymphocytes and the decrease of the Treg cells in the tumor microenvironment compared with the specimen without neoadjuvant chemotherapy. Next, we evaluated the optimal concentration of the anti cance agents to induce immunogenic cell death, and injected them into the lateral side of the mouse followed by the transplantation of the fresh viable cells into the contar-lateral side. The implanted tumor did not grow with lymphocytes and dendritic cells infiltrated ihn the microenvironment.At the present,we are now analyzing the subpopulation of the lymphocytes and their specificity to the tumor.
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