Development of liver tissue regeneration therapy using a novel low-power extracorporeal shock wave for treatment of liver cirrhosis
| Project/Area Number |
23659633
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
MIYATA Go 東北大学, 大学院・医学系研究科, 准教授 (60282076)
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| Co-Investigator(Kenkyū-buntansha) |
SATOMI Susumu 東北大学, その他部局等, 総長 (00154120)
SATO Akira 東北大学, 大学院・医学系研究科, 講師 (20250764)
ITO Kenta 東北大学, 大学院・医学系研究科, 助教 (50375086)
KAWAGISHI Naoki 東北大学, 病院, 准教授 (00333807)
SEKIGUCHI Satoshi 東北大学, 病院, 講師 (20312580)
AKAMATSU Yorihiro 東北大学, 病院, 助教 (50302112)
FUJISIMA Fumiyosi 東北大学, 病院, 助教 (40451596)
NAKANO Toru 東北大学, 病院, 助教 (50451571)
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| Co-Investigator(Renkei-kenkyūsha) |
SATO Yasufumi 東北大学, 加齢医学研究所, 教授 (50178779)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 肝 / 衝撃波 / 肝硬変 / 体外衝撃波 / 肝再生 / 血管新生 |
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| Research Abstract |
There is no silver bullet of the treatment for liver cirrhosis currently and essentially. It is important to prevent the complications and help the function of the cirrhotic liver. Development of new treatments highly effective and minimally invasive is strongly desired. Angiogenic activity and inhibition of myocardial remodeling have been reported by irradiation of the low power extracorporeal shock wave to the ischemic tissue. We elucidate the effect of the low power extracorporeal shock wave for the liver cirrhosis. In this study, we evaluate the liver function, cell regeneration, degree of fibrosis, angiogenic activity and adverse events in the animal model using rat. Although the irradiation of the low power extracorporeal shock wave were performed safely, it is necessary to consider the optimum condition and the biological mechanism further more.
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Report
(3 results)
Research Products
(3 results)
