| Project/Area Number |
23659638
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Chiba University |
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Principal Investigator |
MIYAZAKI Masaru 千葉大学, 大学院・医学研究院, 教授 (70166156)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDOME Hiroyuki 千葉大学, 大学院・医学研究院, 講師 (10312935)
YOSHITOMI Hideyuki 千葉大学, 大学院・医学研究院, 助教 (60375631)
TAKAYASHIKI Tukasa 千葉大学, 大学院医学研究院, 助教 (30456024)
NAKAJIMA Masayuki 千葉大学, 医学部付属病院, 助教 (80466705)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 膵臓外科学 / 神経内分泌腫瘍 / 膵腫瘍 / Pdx-1 / Ngn-3 / 膵内分泌腫瘍 / 膵内分泌癌 / 転写因子 |
|---|
| Research Abstract |
The aim of this study is to reveal the molecular mechanisms underlying tumorigenesis of pancreatic neuroendocrine tumors (pNET). Reevaluating 33 resected cases revealed that patients with Neuroendocrine carcinoma experienced extremely poor prognosis and the development of new therapy is necessary. Strong expression of Pdxl and Ngn3, which play important role in pancreatic development, in NET cells predicted favorable prognosis. These results indicate that these factors induce tumor cell differentiation. We are now trying the molecular roles of these factors using cell line.
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