Molecular mechanisms of tumorigenesis of enteric and pancreatic neuroendocrine tumor and development of new molecular targeting therapy.
| Project/Area Number |
23659638
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Chiba University |
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Principal Investigator |
MIYAZAKI Masaru 千葉大学, 大学院・医学研究院, 教授 (70166156)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDOME Hiroyuki 千葉大学, 大学院・医学研究院, 講師 (10312935)
YOSHITOMI Hideyuki 千葉大学, 大学院・医学研究院, 助教 (60375631)
TAKAYASHIKI Tukasa 千葉大学, 大学院医学研究院, 助教 (30456024)
NAKAJIMA Masayuki 千葉大学, 医学部付属病院, 助教 (80466705)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 膵臓外科学 / 神経内分泌腫瘍 / 膵腫瘍 / Pdx-1 / Ngn-3 / 膵内分泌腫瘍 / 膵内分泌癌 / 転写因子 |
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| Research Abstract |
The aim of this study is to reveal the molecular mechanisms underlying tumorigenesis of pancreatic neuroendocrine tumors (pNET). Reevaluating 33 resected cases revealed that patients with Neuroendocrine carcinoma experienced extremely poor prognosis and the development of new therapy is necessary. Strong expression of Pdxl and Ngn3, which play important role in pancreatic development, in NET cells predicted favorable prognosis. These results indicate that these factors induce tumor cell differentiation. We are now trying the molecular roles of these factors using cell line.
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Report
(3 results)
Research Products
(32 results)
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[Journal Article] Akt/mTOR signaling pathway is crucial for gemcitabine resistance induced by Annexin II in pancreatic cancer cells2012
Author(s)
Kagawa S, Takano S, Yoshitomi H, Kimura F, Satoh M, Shimizu H, Yoshidome H, Ohtsuka M, Kato A, Furukawa K, Matsushita K, Nomura F, Miyazaki M.
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Journal Title
J Surg Res
Volume: 2;178
Pages: 758-767
Related Report
Peer Reviewed
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[Journal Article] Hepatocyte apoptosis is enhanced after ischemia/reperfusion in the steatotic liver.2011
Author(s)
Suzuki T, Yoshidome H, Kimura F, Shimizu H, Ohtsuka M, Takeuchi D, Kato A, Furukawa K, Yoshitomi H, Iida A, Dochi T, Miyazaki M
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Journal Title
J. Clin. Biochem, Nutr
Pages: 48142-148
NAID
Related Report
Peer Reviewed
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[Journal Article] Similarities and differences between intraductal papillary tumors of the bile duct with and without macroscopically visible mucin secretion2011
Author(s)
Ohtsuka M, Kimura F, Shimizu H, Yoshidome H, Kato A, Yoshitomi H, Furukawa K, Takeuchi, D, Takayashiki T, Suda K, TakanoS, Kondo Y, Miyazaki M
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Journal Title
Am J Surg Pathol
Volume: 35
Pages: 512-521
Related Report
Peer Reviewed
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[Presentation] 膵腺傍細胞癌自験例の検討2012
Author(s)
中村祐介,吉富秀幸、木村文夫、清水宏明、吉留博之、大塚将之、加藤厚、古川勝規、竹内男、高屋敷吏、久保木知、鈴木大亮、中島正之、宜崎勝
Organizer
日本膵臓学会雑誌,(27,432,2012)第43回目本膵臓学会大会
Place of Presentation
山形(一般演題)
Year and Date
2012-06-29
Related Report
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[Presentation] Poster Combination of preoperative gemcitabine/S-1 chemotherapy and aggressive surgical resection for borderline or initially unresectable locally advanced pancreatic cancer2012
Author(s)
Yoshitomi H, Shimizu H, Yoshidome H, Ohtsuka M, Kato A, Furukawa H, Takeuchi D, Takayashiki T, Kimura F, Miyazaki M
Organizer
32nd ESSO (European Society of Surgical Oncology)
Place of Presentation
Valencia, Spain
Related Report
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[Presentation] Combination of Preoperative Gemcitabi ne/S-1 Chemotherapy and Aggressive Su rgical Resection for Borderline or In itially Unresectable Locally Advanced Pancreatic Cancer2011
Author(s)
Hideyuki Yoshitomi, Fumio Kimura Hiroaki Shimizu Hiroyuki Yoshidome, Masayuki Ohtsuka, Atsushi Kato, Katsunori Furukawa, Dan Takeuchi, Tsukasa Takayashiki, Satoshi Kuboki, Daisuke Suzuki, Masayuki Nakajima, Masaru Miyazaki.
Organizer
21th IASGO (World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists)
Place of Presentation
Tokyo, Japan
Year and Date
2011-11-11
Related Report
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[Presentation] Frozen section examination of bile duct margins in hilarcholangiocarcinoma2011
Author(s)
Masayuki Nakajima, Masayuki Ohtsuka, Fumio Kimura, Hiroaki Shimizu, Hiroyuki Yoshidome, Atsushi Kato, Hideyuki Yoshitomi, Dan Takeuchi, Katsunori Furukawa, Tsukasa Takayashiki, Kosuke Suda, Satoshi Kuboki, Masaru Miyazaki.
Organizer
International Surgical Week (ISW) 2011
Place of Presentation
Yokohama, Japan
Year and Date
2011-08-31
Related Report
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