Development of Intelligent Gadorinium Neutron Capture Therapy asCancer Specific Atomic Suppression Therapy

• Project/Area Number: 23659639
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: The University of Tokyo
• Principal Investigator: YANAGIE Hironobu 東京大学, 大学院・工学系研究科, 准教授 (30212278)
• Co-Investigator(Kenkyū-buntansha): TAKAHASHI Hiroyuki 東京大学, 大学院・工学系研究科, 教授 (70216753) ; IYOMOTO Naoko 九州大学, エネルギー量子工学部門, 大学院工学研究員 (40508173)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: ガドリニウム化合物 / 中性子捕捉療法 / Drug delivery System / Liposome / 三元複合体 / PEG-C / JTS-1 / X線照射 / Drug Delivery System / Ｘ線照射

Research Abstract

The Colon 26 tumour growth suppression was revealed in treated with gadolinium (Gd)-entrapped liposome with thermal neutron irradiation(5 x 10^12 n/cm^2) (Gd Neutron Capture Therapy). We prepared Gd mixed complex consisted with polyethyleneimine (PEI), polyethylene glycol derivatives having carboxylic acid (PEG-C), and JTS-1 (fusogenic peptide), and the Gd concentration in 2 hours / 12 hours after intratumoral injection are 21.9 / 12.3 ppm. The concentration of Gd is two times highed compared with the control group. The cytotoxic effect was showed 29% suppression by 1.96-mg of Gadteridol with X ray irradiation.

Research Products

• [Journal Article] Tumour Growth Suppression by Gadolinium Neutron Capture Therapy Using Gadolinium-Entrapped Liposome as Gadolinium Delivery Agent (2013)
  • Author(s): Novriana D, Y a na g ie H, Zhu H, Demachi K, Shinohara A, Yokoyama K, Sekino M, Sakurai Y, Morishita Y, Iyomoto N, Nagasaki T, Horiguchi Y, Nagasaki Y, Nakajima J, Ono M & Takahashi H
  • Journal Title: Biomed Pharmacother Volume: (in press)
• [Journal Article] Tumour Growth Suppression by Gadolinium Neutron Capture Therapy Using Gadolinium-Entrapped Liposome as Gadolinium Delivery Agent (2013)
  • Author(s): Novriana Dewi
  • Journal Title: Biomedecine & Pharacotherapy Volume: 67
  • Peer Reviewed
• [Journal Article] Production of Polyoxoboronate as Novel Boron compound for Boron Neutron Capture Therapy (2012)
  • Author(s): H. Yanagie, H. Takahashi, et al
  • Journal Title: Solid State Science (Elsevier) Volume: なし
  • Peer Reviewed
• [Journal Article] Feasibility Evaluation of Neutron Capture Therapy for Hepatocellular Carcinoma using Selective Enhancement of Boron Accumulation in Tumour with Intra-arterial Administration of Boron-Entrapped Water-in-Oil -in-Water Emulsion (2011)
  • Author(s): Yanagie H, Kumada H, Nakamura T, Higashi S, Ikushima I, Morishita Y, Shinohara A, Fijiwara M, Suzuki M, Sakurai Y, Sugiyama H, Kajiyama T, Nishimura R, Ono K, Nakajima J, Minoru O, Eriguchi M, & Takahashi H
  • Journal Title: Applied Radiation & Isotopes Volume: 69(12) Pages: 1854-7
• [Journal Article] 中性子捕捉療法を目指した再発・進行乳癌におけるFBPA-PET診断 (2011)
  • Author(s): 柳衛宏宣、高橋浩之
  • Journal Title: Isotope News Volume: 69(11) Pages: 4-7
• [Journal Article] Feasibility Evaluation of Neutron Capture Therapy for Hepatocellular Carcinoma using Selective Enhancement of Boron Accumulation in Tumour with Intra-arterial Administration of Boron-Entrapped Water-in-Oil-in-Water Emulsion. (2011)
  • Author(s): H. Yanagie, H. Takahashi, et al
  • Journal Title: Applied Radiation & Isotopes Volume: 69(12) Pages: 1854-7
  • Peer Reviewed
• [Journal Article] Production of Polyoxoboronate as Novel Boron compound for Boron Neutron Capture Therapy
  • Author(s): Yanagie H, Shibai A, Inoue S, Miyazaki A, Shinohara A, Yokoyama K, Sakurai Y, Kishi T, Satoh M, Sugiyama H, Hisa T, Kawate M, Yamase T, Ono M, Eriguchi M and Takahashi H
  • Journal Title: Solid State Science
• [Presentation] 三元複合体を用いた胃癌細胞への遺伝子デリバリーシステムの検討 (2013)
  • Author(s): 柳衛宏宣、芝井亜弥、榮光子、江里口正純、久智行、古谷嘉隆、杉山弘高、小山義之、小野稔、中島淳
  • Organizer: 第85回日本胃癌学会総会
  • Place of Presentation: 大阪国際会議場、大阪
  • Year and Date: 2013-02-28
• [Presentation] 原発性肝細胞癌に対する中性子捕捉療法への応用に向けたボロン封入WOWエマルションシステムの検討 (2013)
  • Author(s): 柳衛宏宣、東秀史、瀬口浩司、生嶋一朗、藤原光輝、鈴木実、増永慎一郎、櫻井良憲、田中浩基、木梨友子、丸橋晃、小野公二、江里口正純、小野稔、高橋浩之
  • Organizer: 東京大学先端医療シーズ開発フォーラム
  • Place of Presentation: 東京大学国際学術研究センター、東京
  • Year and Date: 2013-01-25
• [Presentation] Novel Arterial-Injection-Chemotherapy using Epirubicin Entrapped WOW Emulsion for Hepatocellular Carcinoma (2013)
  • Author(s): Yanagie H, Higashi S, Ikushima I, Morishita Y, Mizumachi R, Murata Y, Sakurai Y, Mouri K, Shinohara A, Nagata M, Nagasaki T, Imagawa T, Terao T, Hisa T, Sugiyama H, Nakajima T, Kakimi K, Arimori K, Nishimura R, Eriguchi M, Takamoto S, Ono M, Nakajima J, and Takahashi H
  • Organizer: 3rd Inter-national Conference on Multifunctional, Hybrid and Nanomaterials
  • Place of Presentation: Sorrento, Italy
• [Presentation] Novel Arterial-Injection-Chemotherapy using Epirubicin Entrapped WOW Emulsion for Hepatocellular Carcinoma (2013)
  • Author(s): Yanagie Hironobu
  • Organizer: 3rd International Conference on Multifunctional, Hybrid and Nanomaterials
  • Place of Presentation: Sorrento, Italy
• [Presentation] In Vivo Study of Gadolinium-based Neutron Capture Therapy (2012)
  • Author(s): Novriana D, Yanagie H, Zhu H, Demachi K, Shinohara A, Yokoyama K, Sekino M, Sakurai Y, Morishita Y, Iyomoto N, Nagasaki T, Horiguchi Y, Nagasaki Y, Nakajima J, Ono M & Takahashi H
  • Organizer: 15th International Conference of Neutron Capture Therapy
  • Place of Presentation: Tsukuba, Japan
  • Year and Date: 2012-09-13
• [Presentation] 肝臓癌へのBNCTの実施経験例の検討 (2012)
  • Author(s): 柳衛宏宣、東秀史、瀬口浩司、生嶋一朗、藤原光輝、鈴木実、増永慎一郎、櫻井良憲、田中浩基、木梨友子、丸橋晃、小野公二、江里口正純、小野稔、高橋浩之
  • Organizer: 平成23年度京都大学原子炉実験所専門研究会「研究炉及び加速器中性子源を用いた中性子捕捉療法の高度化に関する研究会」
  • Place of Presentation: 京都大学原子炉実験所、熊取、大阪府
  • Year and Date: 2012-02-18
• [Presentation] 肝臓癌へのBNCTの実施経験例の検討 (2012)
  • Author(s): 柳衛宏宣、高橋浩之、他
  • Organizer: 平成23年度京都大学原子炉実験所専門研究会 「研究炉及び加速器中性子源を用いた中性子捕捉療法の高度化に関する研究会」
  • Place of Presentation: 京都大学原子炉実験所、熊取、大阪府
• [Presentation] Feasible Evaluation of Neutron Capture Therapy for Local Recurrenced Breast Cancer According to Boron Uptake in Tumour with Estimating by F-BPA Positron Emission Tomograpy (2011)
  • Author(s): Yanagie H, Furuya Y, Taniike K, Kumada H, Nakamura T, Horiguchi H, Ogata H, Sugiyama H, Uchiyama K, Ono K, Ono M, Eriguchi M, and Takahashi H
  • Organizer: 東大病院先端医療開発部局合同第 7回 22 世紀医療センターシンポジウム・第 8回 医工連携研究会・第 4回 ティッシュ・エンジニアリング部シンポジウム 「再生医療・細胞医療の早期実用化にむけた開発戦略
  • Place of Presentation: 東京大学医学部教育研究棟鉄門記念講堂、文京区、東京都
  • Year and Date: 2011-12-17
• [Presentation] Production of Polyoxoboronate and BSH Delivery Systems for Boron Neutron Capture Therapy (2011)
  • Author(s): Yanagie H, Shibai A, Inoue S , Miyazaki A, Shinohara A, Yokoyama K, Sakurai Y, Kishi T, Satoh M , Sugiyama H, Hisa T, Kawate M , Yamase T, Ono M, Eriguchi M and Takahashi H
  • Organizer: 17th INTERNATIONAL SYMPOSIUM ON BORON, BORIDES AND RELATED MATERIALS(ISBB2011)
  • Place of Presentation: Istanbul, TURKEY
  • Year and Date: 2011-09-15
• [Presentation] Feasible Evaluation of Neutron Capture Therapy for Local Recurrenced Breast Cancer According to Boron Uptake in Tumour with Estimating by F-BPA Positron Emission Tomograpy (2011)
  • Author(s): Yanagie H, Furuya Y, Taniike K, Kumada H, Nakamura T, Horiguchi H, Ogata H, Sugiyama H, Uchiyama K, Ono K, Ono M, Eriguchi M, and Takahashi H
  • Organizer: AACR 2011
  • Place of Presentation: Orlando, FL,U.S.A.
  • Year and Date: 2011-04-04
• [Presentation] Feasible Evaluation of Neutron Capture Therapy for Local Recurrenced Breast Cancer According to Boron Uptake in Tumour with Estimating by F-BPA Positron Emission Tomograpy. (2011)
  • Author(s): H. Yanagie, H. Takahashi, et al
  • Organizer: AACR 2011
  • Place of Presentation: Orlando, FL, U.S.A.
• [Presentation] Production of Polyoxoboronate and BSH Delivery Systems for Boron Neutron Capture Therapy. (2011)
  • Author(s): H. Yanagie, H. Takahashi, et al
  • Organizer: 17th INTERNATIONAL SYMPOSIUM ON BORON, BORIDES AND RELATED MATERIALS(ISBB2011)(招待講演)
  • Place of Presentation: Istanbul, TURKEY
• [Presentation] 原発性肝細胞癌に対する 中性子捕捉療法への応用に向けた ボロン封入WOWエマルションシステムの検討
  • Author(s): 柳衛宏宣
  • Organizer: 東京大学先端医療シーズ開発フォーラム
  • Place of Presentation: 東京大学国際学術研究センター、東京
  • Invited
• [Presentation] Feasible Evaluation of Neutron Capture Therapy for Local Recurrenced Breast Cancer According to Boron Uptake in Tumour with Estimating by F-BPA Positron Emission Tomograpy.
  • Author(s): H. Yanagie, H. Takahashi, et al
  • Organizer: 東大病院先端医療開発部局合同 第7回 22世紀医療センターシンポジウム・第8回 医工連携研究会・第4回 ティッシュ・エンジニアリング部シンポジウム 「再生医療・細胞医療の早期実用化にむけた開発戦略
  • Place of Presentation: 東京大学医学部教育研究棟鉄門記念講堂、文京区、東京都