Development of Intelligent Gadorinium Neutron Capture Therapy asCancer Specific Atomic Suppression Therapy
| Project/Area Number |
23659639
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YANAGIE Hironobu 東京大学, 大学院・工学系研究科, 准教授 (30212278)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Hiroyuki 東京大学, 大学院・工学系研究科, 教授 (70216753)
IYOMOTO Naoko 九州大学, エネルギー量子工学部門, 大学院工学研究員 (40508173)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ガドリニウム化合物 / 中性子捕捉療法 / Drug delivery System / Liposome / 三元複合体 / PEG-C / JTS-1 / X線照射 / Drug Delivery System / Ｘ線照射 |
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| Research Abstract |
The Colon 26 tumour growth suppression was revealed in treated with gadolinium (Gd)-entrapped liposome with thermal neutron irradiation(5 x 10^12 n/cm^2) (Gd Neutron Capture Therapy). We prepared Gd mixed complex consisted with polyethyleneimine (PEI), polyethylene glycol derivatives having carboxylic acid (PEG-C), and JTS-1 (fusogenic peptide), and the Gd concentration in 2 hours / 12 hours after intratumoral injection are 21.9 / 12.3 ppm. The concentration of Gd is two times highed compared with the control group. The cytotoxic effect was showed 29% suppression by 1.96-mg of Gadteridol with X ray irradiation.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] Tumour Growth Suppression by Gadolinium Neutron Capture Therapy Using Gadolinium-Entrapped Liposome as Gadolinium Delivery Agent2013
Author(s)
Novriana D, Y a na g ie H, Zhu H, Demachi K, Shinohara A, Yokoyama K, Sekino M, Sakurai Y, Morishita Y, Iyomoto N, Nagasaki T, Horiguchi Y, Nagasaki Y, Nakajima J, Ono M & Takahashi H
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Journal Title
Biomed Pharmacother
Volume: (in press)
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[Journal Article] Feasibility Evaluation of Neutron Capture Therapy for Hepatocellular Carcinoma using Selective Enhancement of Boron Accumulation in Tumour with Intra-arterial Administration of Boron-Entrapped Water-in-Oil -in-Water Emulsion2011
Author(s)
Yanagie H, Kumada H, Nakamura T, Higashi S, Ikushima I, Morishita Y, Shinohara A, Fijiwara M, Suzuki M, Sakurai Y, Sugiyama H, Kajiyama T, Nishimura R, Ono K, Nakajima J, Minoru O, Eriguchi M, & Takahashi H
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Journal Title
Applied Radiation & Isotopes
Volume: 69(12)
Pages: 1854-7
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[Journal Article] Production of Polyoxoboronate as Novel Boron compound for Boron Neutron Capture Therapy
Author(s)
Yanagie H, Shibai A, Inoue S, Miyazaki A, Shinohara A, Yokoyama K, Sakurai Y, Kishi T, Satoh M, Sugiyama H, Hisa T, Kawate M, Yamase T, Ono M, Eriguchi M and Takahashi H
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Journal Title
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[Presentation] Novel Arterial-Injection-Chemotherapy using Epirubicin Entrapped WOW Emulsion for Hepatocellular Carcinoma2013
Author(s)
Yanagie H, Higashi S, Ikushima I, Morishita Y, Mizumachi R, Murata Y, Sakurai Y, Mouri K, Shinohara A, Nagata M, Nagasaki T, Imagawa T, Terao T, Hisa T, Sugiyama H, Nakajima T, Kakimi K, Arimori K, Nishimura R, Eriguchi M, Takamoto S, Ono M, Nakajima J, and Takahashi H
Organizer
3rd Inter-national Conference on Multifunctional, Hybrid and Nanomaterials
Place of Presentation
Sorrento, Italy
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[Presentation] In Vivo Study of Gadolinium-based Neutron Capture Therapy2012
Author(s)
Novriana D, Yanagie H, Zhu H, Demachi K, Shinohara A, Yokoyama K, Sekino M, Sakurai Y, Morishita Y, Iyomoto N, Nagasaki T, Horiguchi Y, Nagasaki Y, Nakajima J, Ono M & Takahashi H
Organizer
15th International Conference of Neutron Capture Therapy
Place of Presentation
Tsukuba, Japan
Year and Date
2012-09-13
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[Presentation] Feasible Evaluation of Neutron Capture Therapy for Local Recurrenced Breast Cancer According to Boron Uptake in Tumour with Estimating by F-BPA Positron Emission Tomograpy2011
Author(s)
Yanagie H, Furuya Y, Taniike K, Kumada H, Nakamura T, Horiguchi H, Ogata H, Sugiyama H, Uchiyama K, Ono K, Ono M, Eriguchi M, and Takahashi H
Organizer
東大病院先端医療開発部局合同第 7回 22 世紀医療センターシンポジウム・第 8回 医工連携研究会・第 4回 ティッシュ・エンジニアリング部シンポジウム 「再生医療・細胞医療の早期実用化にむけた開発戦略
Place of Presentation
東京大学医学部教育研究棟鉄門記念講堂、文京区、東京都
Year and Date
2011-12-17
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[Presentation] Production of Polyoxoboronate and BSH Delivery Systems for Boron Neutron Capture Therapy2011
Author(s)
Yanagie H, Shibai A, Inoue S , Miyazaki A, Shinohara A, Yokoyama K, Sakurai Y, Kishi T, Satoh M , Sugiyama H, Hisa T, Kawate M , Yamase T, Ono M, Eriguchi M and Takahashi H
Organizer
17th INTERNATIONAL SYMPOSIUM ON BORON, BORIDES AND RELATED MATERIALS(ISBB2011)
Place of Presentation
Istanbul, TURKEY
Year and Date
2011-09-15
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[Presentation] Feasible Evaluation of Neutron Capture Therapy for Local Recurrenced Breast Cancer According to Boron Uptake in Tumour with Estimating by F-BPA Positron Emission Tomograpy2011
Author(s)
Yanagie H, Furuya Y, Taniike K, Kumada H, Nakamura T, Horiguchi H, Ogata H, Sugiyama H, Uchiyama K, Ono K, Ono M, Eriguchi M, and Takahashi H
Organizer
AACR 2011
Place of Presentation
Orlando, FL,U.S.A.
Year and Date
2011-04-04
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