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Treatment strategy for liver fibrosis by hydrogen water

Research Project

Project/Area Number 23659647
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionKyoto University

Principal Investigator

TAURA Kojiro  京都大学, 医学研究科, 助教 (80378629)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords肝線維化 / 活性酸素 / 星細胞 / 肝細胞 / 肝卵形細胞 / 水素水
Research Abstract

To investigate the effects of hydrogen water on liver fibrogenesis, C57BL/6 mice were fed with hydrogen water or control water, and subjected to carbon tetrachloride, thioacetamide and bile duct ligation treatments to induce liver fibrosis. Oral intake of hydrogen water significantly suppressed liver fibrogenesis in the carbon tetrachloride and thioacetamide models, but these effects were not seen in the bile duct ligation model.To investigate the mechanisms underlying these effects, hepatocytes and hepatic stellate cells were isolated from mice and cultured with or without hydrogen to test the effects of hydrogen on reactive oxygen species-induced hepatocyte injuries or hepatic stellate cell activation. Treatment of isolated hepatocyte with 1 μg/mL antimycin A generated hydroxyl radicals. Culturing in the hydrogen-rich medium selectively suppressed the generation of hydroxyl radicals in hepatocytes and significantly suppressed hepatocyte death induced by antimycin A; however, it did not suppress hepatic stellate cell activation. We conclude that hydrogen water protects hepatocytes from injury by scavenging hydroxyl radicals and thereby suppresses liver fibrogenesis in mice.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (37 results)

All 2014 2013 2012 2011

All Journal Article (32 results) (of which Peer Reviewed: 19 results) Presentation (5 results)

  • [Journal Article] Sorafenib in a hepatocellular carcinoma patient with end-stage renal failure: A pharmacokinetic study.2014

    • Author(s)
      Ishii T, Hatano E, Taura K, Mizuno T, Kawai T, Fukudo M, Katsura T, Uemoto S.
    • Journal Title

      Hepatology Research

      Volume: 44 Issue: 6 Pages: 685-688

    • DOI

      10.1111/hepr.12156

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of oral intake of hydrogen water on liver fibrogenesis in mice2013

    • Author(s)
      Koyama Y, Taura K, Hatano E, Tanabe K, Yamamoto G, Nakamura K, Yamanaka K, Kitamura K, Narita M, Nagata H, Yanagida A, Iida T, Iwaisako K, Fujinawa H, Uemoto S
    • Journal Title

      Hepatol Res

      Volume: May 20 Issue: 6 Pages: 663-677

    • DOI

      10.1111/hepr.12165

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 消化器外科医が知っておくべき血管外科手技2013

    • Author(s)
      田浦康二朗, 波多野悦朗, 池野嘉信, 上本伸二
    • Journal Title

      肝腫瘍に対する下大静脈合併切除・再建術(解説/特集) 手術

      Volume: 67巻 Pages: 297-302

    • URL

      http://www.kanehara-shuppan.co.jp/journal/guide.html

    • Related Report
      2012 Final Research Report
  • [Journal Article] 進行胆道癌(Stage III、IV)切除後長期生存例からみた治療方針2013

    • Author(s)
      石井隆道 波多野悦朗 田浦康二朗 上本伸二
    • Journal Title

      進行胆道癌の長期生存に関わる予後因子の解析ならびに再発症例に対する治療方針の検討(原著論文/特集) 癌の臨床

      Volume: 59巻 Pages: 33-37

    • URL

      http://www.shinoharashinsha.co.jp/

    • Related Report
      2012 Final Research Report
  • [Journal Article] 肝胆膵外科手術におけるシミュレーションとナビゲーション2013

    • Author(s)
      田浦康二朗 波多野悦朗 石井隆道 上本伸二
    • Journal Title

      3D CT angiographyとcholangiographyのfusion画像による胆道癌手術プラニング(解説/特集)

      Volume: 34巻 Pages: 81-85

    • URL

      http://www.igakutosho.co.jp/

    • Related Report
      2012 Final Research Report
  • [Journal Article] Effect of olprinone on liver microstructure in rat partial liver transplantation2013

    • Author(s)
      Yamanaka K, Hatano E, Iguchi K, Yamamoto G, Sato M, Toriguchi K, Tanabe K, Takemoto K, Nakamura K, Koyama N, Narita M, Nagata H, Taura K, Uemoto S
    • Journal Title

      J Surg Res

      Volume: 183(1) Issue: 1 Pages: 391-396

    • DOI

      10.1016/j.jss.2012.11.033

    • NAID

      120005298136

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Origin of myofibroblasts in liver fibrosis.2012

    • Author(s)
      Brenner DA
    • Journal Title

      Fibrogenesis Tissue Repair.

      Volume: Jun 6;5 Suppl 1 Issue: S1

    • DOI

      10.1186/1755-1536-5-s1-s17

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of olprinone on liver microstructure in rat partial liver transplantation.2012

    • Author(s)
      Yamanaka K, Hatano E, Taura K, Uemoto S
    • Journal Title

      J Surg Res

    • NAID

      120005298136

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sorafenib attenuates monocrotaline-induced sinusoidal obstruction syndrome in rats through suppression of JNK and MMP-9.2012

    • Author(s)
      Nakamura Koijro
    • Journal Title

      J Hepatol.

      Volume: Nov;57(5) Issue: 5 Pages: 1037-43

    • DOI

      10.1016/j.jhep.2012.07.004

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] An eClinical trial system for cancer that integrates with clinical pathways and electronic medical records2012

    • Author(s)
      Yamamoto K, Yamanaka K, Taura K, Fukushima M
    • Journal Title

      Clin Trials

      Volume: 9巻 Issue: 4 Pages: 408-417

    • DOI

      10.1177/1740774512445912

    • NAID

      120005323017

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist2012

    • Author(s)
      Iwaisako K, Haimerl M, Paik YH, Taura K, Kodama Y, Sirlin C, Yu E, Yu RT, Downes M, Evans RM, Brenner DA, Schnabl B
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 109 Issue: 21 Pages: 1369-76

    • DOI

      10.1073/pnas.1202464109

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 肝細胞癌に対する治療の現状と標準化2012

    • Author(s)
      波多野悦朗 瀬尾智 田浦康二朗上本伸二
    • Journal Title

      肝動脈注入化学療法により切除可能となった高度脈管侵襲を伴う切除不能進行肝細胞癌(解説/特集), 消化器内科

      Volume: 55巻 Pages: 656-661

    • URL

      http://www.kahyo.com/

    • Related Report
      2012 Final Research Report
  • [Journal Article] 肝細胞癌のすべて20122012

    • Author(s)
      波多野悦朗 瀬尾智 田浦康二朗上本伸二
    • Journal Title

      治療法の進歩 高度進行癌の外科治療(解説/特集) 肝・胆・膵

      Volume: 65巻 Pages: 1211-1217

    • URL

      http://www.arcmedium.co.jp/

    • Related Report
      2012 Final Research Report
  • [Journal Article] 肝内胆管癌診療のトピックス2012

    • Author(s)
      波多野悦朗 瀬尾智 田浦康二朗上本伸二
    • Journal Title

      肝内胆管癌におけるPET/CTの意義(解説/特集) 日本消化器病学会

      Volume: 109巻 Pages: 1878-1884

    • URL

      http://mol.medicalonline.jp/library/journal/download?GoodsID=ck8syokb/2012/010911/003&name=1878-1884j&UserID=130.54.130.240&base=jamas_pdf

    • Related Report
      2012 Final Research Report
  • [Journal Article] Radiation therapy for tumor thrombus in the portal vein or inferior vena cava in unresectable hepatocellular carcinoma2012

    • Author(s)
      小山幸法 波多野悦朗 田浦康二朗 上本伸二
    • Journal Title

      Kanzo

      Volume: 53 Issue: 8 Pages: 486-493

    • DOI

      10.2957/kanzo.53.486

    • NAID

      130002098035

    • ISSN
      0451-4203, 1881-3593
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 胆嚢癌フロントライン2012

    • Author(s)
      金井雅史 波多野悦朗 田浦康二朗 上本伸二
    • Journal Title

      薬物治療 GEM/S-1併用療法による切除不能胆道癌の治療成績, 肝・胆・膵

      Volume: 64巻 Pages: 599-605

    • URL

      http://mol.medicalonline.jp/library/journal/download?GoodsID=ao1ktsud/2012/006404/020&name=0599-0605j&UserID=130.54.130.240&base=jamas_pdf

    • Related Report
      2012 Final Research Report
  • [Journal Article] 手術助手にはこうしてほしい2012

    • Author(s)
      波多野悦朗 岡村裕輔 田浦康二朗 上本伸二
    • Journal Title

      肝胆膵領域 肝尾状葉切除術, 外科

      Volume: 74巻 Pages: 12-15

    • URL

      http://www.nankodo.co.jp/

    • Related Report
      2012 Final Research Report
  • [Journal Article] Early evaluation of Tran catheter arterial chemoembolization-refractory hepatocellular carcinoma2011

    • Author(s)
      Yamanaka K, Hatano E, Kitamura K, Iida T, Ishii T, Machimito T, Taura K, Yasuchika K, Isoda H, Shibata T, Uemoto S.
    • Journal Title

      J Gastroenterol

      Volume: (Epub ahead of print) Issue: 3 Pages: 343-346

    • DOI

      10.1007/s00535-011-0511-x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preoperative FDG-PET predicts recurrence patterns in hepatocellular carcinoma.2011

    • Author(s)
      Kitamura K, Hatano E, Taura K, Uemoto S
    • Journal Title

      Ann Surg Oncol

      Volume: 19 Issue: 1 Pages: 156-162

    • DOI

      10.1245/s10434-011-1990-y

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Downregulation of the Wnt antagonist Dkk2 links the loss of Sept4 and myofibroblastic transformation of hepatic stellate cells2011

    • Author(s)
      Yanagida A, Iwaisako K, Hatano E, Taura K, Sato F, Narita M, Nagata H, Asechi H, Uemoto S, Kinoshita M
    • Journal Title

      BBA-Molecular Basis of Disease

      Volume: 812 Issue: 11 Pages: 1403-1411

    • DOI

      10.1016/j.bbadis.2011.06.015

    • NAID

      120003517932

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Non-alcoholic steatohepatitis-induced fibrosis : Toll-like receptors, reactive oxygen species and Jun N-terminal kinase2011

    • Author(s)
      Brenner DA, Seki E, Taura K, Kisseleva T, Deminicis S, Iwaisako K, Inokuchi S, Schnabl B, Oesterreicher CH, Paik YH, Miura K, Kodama Y
    • Journal Title

      Hepatology Research

      Volume: 41 Issue: 7 Pages: 683-686

    • DOI

      10.1111/j.1872-034x.2011.00814.x

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Proliferative activity in hepatocellular carcinoma is closely correlated with glucose metabolism but not angiogenesis2011

    • Author(s)
      Kitamura K, Hatano E, Taura K, Uemoto S
    • Journal Title

      J Hepatol

      Volume: 55巻 Issue: 4 Pages: 846-857

    • DOI

      10.1016/j.jhep.2011.01.038

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative study of cisplatin and epirubicin in Tran catheter arterial chemoembolization for hepatocellular carcinoma2011

    • Author(s)
      Yamanaka K, Hatano E, Narita M, Taura K, Yasuchika K, Nitta T, Arizono S, Isoda H, Shibata T, Ikai I, Sato T, Uemoto S.
    • Journal Title

      Hepatol Res

      Volume: 41(4) Issue: 4 Pages: 303-309

    • DOI

      10.1111/j.1872-034x.2010.00770.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Olprinone attenuates excessive shear stress through up-regulation of endothelial nitric oxide synthase in a rat excessive hepatectomy model2011

    • Author(s)
      Yamanaka K, Hatano E, Taura K, Uemoto S
    • Journal Title

      Liver Transpl

      Volume: 17巻 Issue: 1 Pages: 60-69

    • DOI

      10.1002/lt.22189

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A multi-institution phase II study of gemcitabine/S-1 combination chemotherapy for patients with advanced biliary tract cancer2011

    • Author(s)
      Kanai M, Yoshimura K, Taura K, Hatano E
    • Journal Title

      Cancer Chemothera Pharmacol

      Volume: 67巻 Issue: 6 Pages: 1429-1434

    • DOI

      10.1007/s00280-010-1443-5

    • NAID

      120003238952

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic value of (18)F-fluorodeoxyglucose positron emission tomography in patients with extrahepatic bile duct cancer2011

    • Author(s)
      Kitamura K, Hatano E, Taura K, Uemoto S
    • Journal Title

      J hepatobiliary Pancreat Sci

      Volume: 18巻 Issue: 1 Pages: 39-46

    • DOI

      10.1007/s00534-010-0293-1

    • NAID

      10028172980

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 他科との連携手術-知っておくべき最新の知識2011

    • Author(s)
      波多野悦朗 三和千里 田浦康二朗 上本伸二
    • Journal Title

      呼吸器外科、心臓・血管外科との連携 肝癌の心大血管内腫瘍栓, 外科

      Volume: 73巻 Pages: 1437-1442

    • URL

      http://www.nankodo.co.jp/

    • Related Report
      2012 Final Research Report
  • [Journal Article] Prognostic Value of Intraoperative Peritoneal Cytology in Biliary Tract Cancer2011

    • Author(s)
      山中健也 波多野悦朗 田浦康二朗 上本伸二
    • Journal Title

      The Japanese Journal of Gastroenterological Surgery

      Volume: 44 Issue: 7 Pages: 803-808

    • DOI

      10.5833/jjgs.44.803

    • NAID

      130004560718

    • ISSN
      0386-9768, 1348-9372
    • Related Report
      2012 Final Research Report
  • [Journal Article] 下大静脈にかかわる病態を見直す2011

    • Author(s)
      波多野悦朗 小山幸法 田浦康二朗 上本伸二
    • Journal Title

      治療方針下大静脈内腫瘍栓を伴う肝癌の治療方針, 臨床外科

      Volume: 66巻 Pages: 1201-1207

    • URL

      http://www.igaku-shoin.co.jp/journalDetail.do?journal=32347

    • Related Report
      2012 Final Research Report
  • [Journal Article] Incidental Gallbladder Cancer2011

    • Author(s)
      田浦康二朗 波多野悦朗 安近健太郎 上本伸二
    • Journal Title

      偶発胆嚢癌に対する腹腔鏡下胆嚢摘出術後ポート部位再発の検討, 胆と膵

      Volume: 32巻 Pages: 425-429

    • URL

      http://mol.medicalonline.jp/library/journal/download?GoodsID=aa6tnsid/2011/003205/013&name=0425-0429j&UserID=130.54.130.240&base=jamas_pdf

    • Related Report
      2012 Final Research Report
  • [Journal Article] 肝区域と画像診断update2011

    • Author(s)
      田浦康二朗 小倉靖弘 上本伸二
    • Journal Title

      画像からみた新しい肝の解剖学的理解と臨床応用 肝移植のための区域診断, 肝胆膵画像

      Volume: 13巻 Pages: 456-460

    • URL

      http://www.igakutosho.co.jp/

    • Related Report
      2012 Final Research Report
  • [Journal Article] Proliferative activity in hepatocellular carcinoma is closely correlated with glucose metabolism but not angiogenesis.2011

    • Author(s)
      Kitamura K, Taura K et al.
    • Journal Title

      J Hepatol.

      Volume: 4 Pages: 846-57

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 3D CT cholangiographyを活用した肝門部胆管癌に対する術式選択と手術プラニング2012

    • Author(s)
      田浦 康二朗
    • Organizer
      日本外科学会総会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Plissimo Eraを用いた 肝切除術のVirtual Reality2012

    • Author(s)
      田浦 康二朗
    • Organizer
      日本消化器外科学会
    • Place of Presentation
      富山国際会議場(富山市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Usefulness of Liver Stiffness Measurement for the Prediction of Posthepatectomy Liver Failure2012

    • Author(s)
      Taura Kojiro
    • Organizer
      The 63rd Annual Meeting of the American Association for the Study of Liver Disease
    • Place of Presentation
      Hynes Convention Center (Boston, USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 肝胆膵外科における Virtual 3D画像と 臓器立体モデルへの取り組み2012

    • Author(s)
      田浦 康二朗
    • Organizer
      日本内視鏡外科学会総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Three-Dimensional Image of Hepatic Hilum by CT Cholangiography with Carbon Dioxide for Preoperative Assessment of Biliary Malignancies2012

    • Author(s)
      田浦 康二朗
    • Organizer
      Internationa Forum of Liver Surgery
    • Place of Presentation
      セイコーグランドホテル(秋田県)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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