Noveltechnology for imuse cell induction.
Project/Area Number |
23659648
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Digestive surgery
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Research Institution | Osaka University |
Principal Investigator |
MORI Masaki 大阪大学, 医学系研究科, 教授 (70190999)
|
Co-Investigator(Kenkyū-buntansha) |
EGUCHI Hidetoshi 大阪大学, 医学系研究科, 助教 (90542118)
ISHII Hideshi 大阪大学, 医学系研究科, 教授 (10280736)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 再生医学 / 外科学 / ES 細胞 / 再生医 / ES細胞 |
Research Abstract |
Given that multilineage differentiating stress enduring (Muse) cells exist in adult skin fibroblasts and bone marrow stroma and possess stress tolerance and endogenous pluripotency, we studied the possible induction of Muse-like cells by miRNAs (iMuse cells). The iMuse cells have a potentially usefulness for the regenerative medicine as safety and efficiency. While expression of SSEA-3 showed specifically the relationship of representative stem markers as well as with mesenchymal stem cell/Muse cell markers in normal and cancer cells. Further study would be necessary for the final clinical setting.
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Report
(3 results)
Research Products
(77 results)
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[Journal Article] microRNA-181a is associated with poor prognosis of colorectal cancer.2012
Author(s)
Nishimura J.Handa R., Yamamoto H., Tanaka F., Shibata K., Mimori K., Takemasa I., Mizushima T., Ikeda M., Sekimoto M., Ishii H., Doki Y., Mori M
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Journal Title
Oncol Rep
Volume: 28(6)
Pages: 2221-2226
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[Journal Article] Biological and clinical availability of adipose-derived stem cells for pelvic dead space repair2012
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Takahashi H., Haraguchi N.Nishikawa S., Miyazaki S., Suzuki Y., Mizushima T., Nishimura J., Takemasa I., Yamamoto H., Mimori K., Ishii H., Doki Y., Mori M
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Journal Title
Stem Cells Transl Med.
Volume: 1(11)
Pages: 803-810
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[Journal Article] Overexpression of PFTK1 predicts resistance to chemotherapy in patients with oesophageal squamous cell carcinoma2012
Author(s)
Miyagaki H.Yamasaki M., Miyata H., Takahashi T., Kurokawa Y., Nakajima K., Takiguchi S., Fujiwara Y., Ishii H., Tanaka F., Mori M., Doki Y
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Journal Title
Br J Cancer.
Volume: 106(5)
Pages: 947-954
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[Journal Article] MicroRNA-372 is associated with poor prognosis in colorectal cancer2012
Author(s)
Yamashita S.Yamamoto H., Mimori K., Nishida N., Takahashi H., Haraguchi N., Tanaka F., Shibata K., Sekimoto M., Ishii H., Doki Y., Mori M.
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Journal Title
Oncology
Volume: 82(4)
Pages: 205-212
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[Journal Article] Oncofetal protein, IMP-3, a potential marker for prediction of postoperative peritoneal dissemination in gastric adenocarcinoma2012
Author(s)
Okada K.Fujiwara Y., Nakamura Y., Takiguchi S., Nakajima K., Miyata H., Yamasaki M., Kurokawa Y., Takahashi T., Mori M., Doki Y
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Journal Title
J Surg Oncol
Volume: 105(8)
Pages: 780-785
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[Journal Article] Circulating microRNA-21 as a novel biomarker for hepatocellular carcinoma2012
Author(s)
Tomimaru Y.Eguchi H., Nagano H., Wada H., Kobayashi S., Marubashi S., Tanemura M., Tomokuni A., Takemasa I., Umeshita K., Kanto T., Doki Y., Mori M
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Journal Title
J Hepatol
Volume: 56(1)
Pages: 167-175
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[Journal Article] IGFBP7 downregulation is associated with tumor progression and clinical outcome in hepatocellular carcinoma2012
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Tomimaru Y.Eguchi H., Wada H., Kobayashi S., Marubashi S., Tanemura M., Umeshita K., Kim T., Wakasa K., Doki Y., Mori M., Nagano H
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Journal Title
Int J Cancer
Volume: 130(2)
Pages: 319-327
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[Journal Article] A case of simultaneous transvaginal NOTES gastrectomy and vaginal hysterectomy in a patient with gastric submucosal tumor and uterine prolapse2012
Author(s)
Hirota M.Nakajima K., Hara J., Takahashi T., Yamasaki M., Tsutsui T., Kobayashi E., Kurokawa Y., Miyata H., Takiguchi S., Mori M., Doki Y
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Journal Title
Asian J Endosc Surg
Volume: 5(4)
Pages: 168-171
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[Journal Article] Role of the Hypoxia-Related Gene, JMJD1A, in Hepatocellular Carcinoma: Clinical Impact on Recurrence after Hepatic Resection.2012
Author(s)
Yamada D.Kobayashi S., Yamamoto H., Tomimaru Y., Noda T., Uemura M., Wada H., Marubashi S., Eguchi H., Tanemura M., Doki Y., Mori M., Nagano H
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Journal Title
Ann Surg Oncol
Volume: 19(3)
Pages: 355-364
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[Journal Article] Genomic copy number of a carcinogenic single nucleotide polymorphism at 8q24 in non-risk allele colorectal cancer associated with insulin growth factor 2 receptor expression.2012
Author(s)
Takahashi Y.Mimori K., Yamamoto K., Watanabe M., Tanaka J., Kudo SE., Sugihara K., Hase K., Mochizuki H., Kusunoki M., Yamada K., Shimada Y., Moriya Y., Mori M
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Journal Title
J Gastroenterol Hepatol
Volume: 3
Pages: 95-99
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[Journal Article] Genotoxic therapy stimulates error-prone DNA repair in dormant hepatocellular cancer stem cells.2012
Author(s)
Nishikawa S.Ishii H., Haraguchi N., Kano Y., Fukusumi T., Ohta K., Ozaki M., Sakai D., Satoh T., Nagano H., Doki Y., Mori M
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Journal Title
Exp Ther Med
Volume: 3(6)
Pages: 959-962
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[Journal Article] microRNA-based cancer cell reprogramming technology (Review).2012
Author(s)
Nishikawa S.Ishii H., Haraguchi N., Kano Y., Fukusumi T., Ohta K., Ozaki M., Dewi DL., Sakai D., Satoh T., Nagano H., Doki Y., Mori M.
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Journal Title
Exp Ther Med
Volume: 4(1)
Pages: 8-14
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[Journal Article] Transcriptomic study of dormant gastrointestinal cancer stem cells2012
Author(s)
Nishikawa S.Dewi D., Ishii H., Konno M., Haraguchi N, Kano Y., Fukusumi T., Ohta K., Noguchi Y., Ozaki M., Sakai D., Satoh T., Doki Y., Mori M
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Journal Title
Int J Oncol
Volume: 41(3)
Pages: 979-984
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[Journal Article] Increased risk for CRC in diabetic patients with the nonrisk allele of SNPs at 8q242012
Author(s)
Ishimaru S.Mimori K., Yamamoto K., Inoue H., Imoto S., Kawano S., Yamaguchi R., Sato T., Toh H., Iinuma H., Maeda T., Ishii H., Suzuki S., Tokudome S., Watanabe M., Tanaka J., Kudo SE., Sugihara K., Hase K., Mochizuki H., Kusunoki M., Yamada K., Shimada Y
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Journal Title
Ann Surg Oncol
Volume: 19(9)
Pages: 2853-2858
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[Journal Article] Deficiency of N-acetylgalactosamine in O-linked oligosaccharides of IgA is a novel biologic marker for Crohn's disease2012
Author(s)
Inoue T. Iijima H., Tajiri M., Shinzaki S., Shiraishi E., Hiyama S., Mukai A., Nakajima S., Iwatani H., Nishida T., Mizushima T., Yasui T., Isaka Y., Kanto T., Tsujii M., Miyoshi E., Wada Y., Takehara T.
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Inflamm Bowel Dis
Volume: 18(9)
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[Journal Article] Aberrant DNA methylation associated with aggressiveness of gastrointestinal stromal tumour2012
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Journal Title
Gut
Volume: 61(3)
Pages: 392-401
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[Journal Article] Increased CD13 expression reduces reactive oxygen species, promoting survival of liver cancer stem cells via an epithelial-mesenchymal transition-like phenomenon.2012
Author(s)
Kim HM.Haraguchi N., Ishii H., Ohkuma M., Okano M., Mimori K., Eguchi H., Yamamoto H., Nagano H., Sekimoto M., Doki Y., Mori M.
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Journal Title
Ann Surg Oncol.
Volume: 3
Pages: 539-548
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[Journal Article] PLOD2 induced under hypoxia is a novel prognostic factor for hepatocellular carcinoma after curative resection.2012
Author(s)
Noda T. Yamamoto H., Takemasa I., Yamada D., Uemura M., Wada H., Kobayashi S., Marubashi S., Eguchi H., Tanemura M., Umeshita K., Doki Y., Mori M., Nagano H
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Journal Title
Liver Int
Volume: 32(1)
Pages: 110-118
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[Journal Article] ErbB receptor tyrosine kinase/NF-κB signaling controls mammosphere formation in human breast cancer2012
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Hinohara K.Kobayashi S., Kanauchi H., Shimizu S., Nishioka K., Tsuji E., Tada K., Umezawa K., Mori M., Ogawa T., Inoue J., Tojo A., Gotoh N.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 109(17)
Pages: 6584-6589
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[Journal Article] Hypoxia and TP53 deficiency for induced pluripotent stem cell-like properties in gastrointestinal cancer.2012
Author(s)
Hoshino H.Nagano H., Haraguchi N., Nishikawa S., Tomokuni A., Kano Y., Fukusumi T., Saito T., Ozaki M., Sakai D., Satoh T., Eguchi H., Sekimoto M., Doki Y., Mori M., Ishii H
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Int J Oncol
Volume: 40(5)
Pages: 1423-1430
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[Journal Article] I/II study of S-1 plus cisplatin combined with peptide vaccines for human vascular endothelial growth factor receptor 1 and 2 in patients with advanced gastric cancer2012
Author(s)
Masuzawa T.Fujiwara Y., Okada K., Nakamura A., Takiguchi S., Nakajima K.,Miyata H., Yamasaki M., Kurokawa Y., Osawa R., Takeda K., Yoshida K., Tsunoda T., Nakamura Y., Mori M., Doki Y.
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Int J Oncol
Volume: 41(4)
Pages: 1297-1304
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[Journal Article] Biased usage of T cell receptor β-chain variable region genes of Wilms' tumor gene (WT1)-specific CD8+ T cells in patients with solid tumors and healthy donors2012
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Mori Moto S.Oka Y., Tsuboi A., Tanaka Y., Fujiki F., Nakajima H., Hosen N., Nishida S., Nakata J., Nakae Y., Maruno M., Myoui A., Enomoto T., Izumoto S., Sekimoto M., Kagawa N., Hashimoto N., Yoshimine T., Oji Y., Kumanogoh A., Sugiyama H
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Journal Title
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