| Project/Area Number |
23659651
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Okayama University |
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Principal Investigator |
UNO Futoshi 岡山大学, 岡山大学病院, 助教 (90572503)
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| Co-Investigator(Renkei-kenkyūsha) |
FUJIWARA Toshiyoshi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (00304303)
KAGAWA Shunsuke 岡山大学, 岡山大学病院, 講師 (00362971)
NISHIZAKI Masahiko 岡山大学, 岡山大学病院, 助教 (30379789)
NAGASAKA Takeshi 岡山大学, 岡山大学病院, 助教 (30452569)
TAZAWA Hiroshi 岡山大学, 岡山大学病院, 助教 (90415513)
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| Research Collaborator |
SHIGEYAU Kunitoshi 岡山大学, 大学院・医歯薬学総合研究科, 大学院生
HASHIMOTO Yuuri 岡山大学, 大学院・医歯薬学総合研究科, 大学院生
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 消化管間質腫瘍(GIST) / 血中浮遊腫瘍細胞(CTC) / 遺伝子解析 |
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| Research Abstract |
We detected circulating tumor cells (CTCs) in the peripheral blood of Gastrointestinal Stromal Tumor (GIST) patients after some fundamental research useing a green fluorescent protein (GFP)-expressing attenuated adenovirus-5 vector, in which the hTERT promoter regulates viral replication (TelomeScan). CTCs were identified in samples from 6 of 12 patients with GIST. These results suggest that CTSs detection with our method might be a new bio-marker for GIST which frequently accompanied liver metastases.
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