• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The development of pancreatic cancer therapy based on regulating pancreatic cancer desmoplasia by targeting pancreatic stellate cells to improve drug delivery

Research Project

Project/Area Number 23659652
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionKyushu University

Principal Investigator

NAGAI Eishi  九州大学, 医学研究院, 准教授 (30264021)

Co-Investigator(Kenkyū-buntansha) INOUE Shigetaka  九州大学, 医学研究院, 共同研究員 (00529802)
ONIMARU Manabu  九州大学, 医学研究院, 共同研究員 (80529876)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords膵癌 / 膵星細胞 / ピルフェニドン / desmoplasia / pancreatic cancer / pirfenidone / gemcitabine / periostin
Research Abstract

We indentified that the antifibrotic agent pirfenidone could suppress desmoplasia and exert anti-tumor effects against pancreatic cancer. In vitro, pirfenidone inhibited the proliferation, invasiveness, and migration of pancreatic stellate cells and tumor-stromal interaction between pancreatic stellate cells and pancreatic cancer cells. Oral administration of pirfenidone to the mice, which implanted with pancreatic cancer cells and pancreatic stellate cells, significantly reduced tumor growth. Pirfenidone also decreased the proliferation of pancreatic stellate cells, and inhibited the deposition of collagen type I and periostin in tumors. Pirfenidone in combination with gemcitabine more effectively suppressed tumor growth compared with pirfenidone or gemcitabine alone. Our findings indicate that pirfenidone is a promising antitumor agent for pancreatic cancer, owing to its suppression of desmoplasia through regulating pancreatic cancer cells.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (13 results)

All 2013 2011 Other

All Journal Article (8 results) (of which Peer Reviewed: 1 results) Presentation (5 results)

  • [Journal Article] Pirfenidone inhibits desmoplasia of pancreatic cancer by regulating stellate cells.2013

    • Author(s)
      Shingo Kozono, Kenoki Ohuchida, Daiki Eguchi, Naoki Ikenaga, Kenji Fujiwara, Ming Zhao, Lin Cui, Koji Shindo, Kazuhiro Mizumoto, and Masao Tanaka
    • Journal Title

      Cancer Research

      Volume: 73 Issue: 7 Pages: 2345-2356

    • DOI

      10.1158/0008-5472.can-12-3180

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Senescence in intraductal papillary mucinous neoplasm of the pancreas2011

    • Author(s)
      Miyasaka Y, Nagai E, O huchida K, Fujita H, Nakata K, Hayashi A, Mizumoto K, Tsuneyoshi M, Tanaka M
    • Journal Title

      Human Pathology

      Volume: 42(12) Pages: 2010-2017

    • Related Report
      2012 Final Research Report
  • [Journal Article] Inhibition of p600 expression suppresses both invasiveness and anoikis resistance of gastric cancer2011

    • Author(s)
      Sakai H, Ohuchida K, Mizumoto K, Cui L, Nakata K, Toma H, Nagai E, Tanaka M
    • Journal Title

      Ann Surg Oncol

      Volume: 18(8) Pages: 2381-2387

    • Related Report
      2012 Final Research Report
  • [Journal Article] hTERT -promoter-dependent oncolytic adenovirus enhances the transduction and therapeutic efficacy of replication-defective adenovirus vectors in pancreatic cancer cells2011

    • Author(s)
      Onimaru M, Ohuchida K, Mizumoto K, Nagai E, Cui L, Toma H, Takayama K, Matsumoto K, Hashizume M, Tanaka M
    • Journal Title

      Cancer Sci

      Volume: 101(3) Pages: 735-742

    • NAID

      10026589785

    • Related Report
      2012 Final Research Report
  • [Journal Article] MicroRNA-10a is overexpressed in human pancreatic cancer and involved in its invasiveness partially via suppression of the HOXA gene2011

    • Author(s)
      Ohuchida K, Mizumoto K, Nagai E, Tanaka M et al
    • Journal Title

      Ann Surg Oncol

      Volume: 19(7) Pages: 2394-402

    • Related Report
      2012 Final Research Report
  • [Journal Article] MicroRNA-10b is overexpressed in pancreatic cancer, promotes its invasiveness and is correlated with a poor prognosis2011

    • Author(s)
      Nakata K, Ohuchida K, Mizumoto K, Nagai E Tanaka M
    • Journal Title

      Surgery

      Volume: 150 Pages: 916-22

    • Related Report
      2012 Final Research Report
  • [Journal Article] MicroRNA expression as a predictive marker for gemcitabine response after surgical resection of pancreatic cancer2011

    • Author(s)
      Ohuchida K, Mizumoto K, Kayashima T, Ueda J, Nagai E, Tanaka M
    • Journal Title

      Ann Surg Oncol

      Volume: 18(8) Pages: 2381-7

    • Related Report
      2012 Final Research Report
  • [Journal Article] 【膵癌診療と研究の最先端】 膵癌における癌間質相互作用2011

    • Author(s)
      大内田 研宙 他
    • Journal Title

      胆と膵

      Volume: 32 Pages: 807-810

    • Related Report
      2011 Research-status Report
  • [Presentation] Pirfenidone inhibits proliferation, invasiveness, the chemokine and stromal component production of pancreatic satellate cells2011

    • Author(s)
      Kozono S et al
    • Organizer
      42nd APA Annual Meeting
    • Place of Presentation
      Chicago, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] 膵癌における膵星細胞およびその癌間質相互作用を標的とした新しい膵癌治療の可能性2011

    • Author(s)
      小薗 真吾 他
    • Organizer
      第22回日本消化器癌発生学会総会
    • Place of Presentation
      佐賀県
    • Related Report
      2011 Research-status Report
  • [Presentation] Pirfenidoneによる膵星細胞を標的とした新しい膵癌治療の可能性

    • Author(s)
      小薗真吾
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
  • [Presentation] Pirfenidoneによる膵星細胞およびその癌間質相互作用を標的とした膵癌治療の可能性

    • Author(s)
      小薗真吾
    • Organizer
      第43回日本膵臓学会大会
    • Place of Presentation
      山形
    • Related Report
      2012 Annual Research Report
  • [Presentation] ntifibrotic Agent, Pirfenidone, Inhibits Pancreatic Stellate Cells and Tumor-Stromal Interaction in Pancreatic Cancer

    • Author(s)
      Shingo Kozono
    • Organizer
      2012 Joint Meeting of APA and IAP
    • Place of Presentation
      Miami, USA
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi