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The development of pancreatic cancer therapy based on the new mechanism of pancreatic cancer invasion

Research Project

Project/Area Number 23659653
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionKyushu University

Principal Investigator

OHUCHIDA Kenoki  九州大学, 医学研究院, 講師 (20452708)

Co-Investigator(Kenkyū-buntansha) UEDA Junji  九州大学, 大学病院, 助教 (90529801)
MANABE Tatsuya  九州大学, 医学研究院, 助教 (60546464)
Project Period (FY) 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords膵臓外科学 / 膵癌 / コラーゲンリモデリング / EMT
Research Abstract

We identified and characterized CD280 positive pancreatic cancer cells with high malignant potential. Moreover, we clarified that collagen-internalization receptor CD280 was important molecule for invasion of pancreatic cancer cells. We found that the invasion of pancreatic cancer cells was reduced by inhibition of CD280 expression.

Report

(2 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (18 results)

All 2012 2011 Other

All Journal Article (11 results) Presentation (4 results) Book (3 results)

  • [Journal Article] Significance of combination therapy of zoledronic acid and gemcitabine on pancreatic cancer2012

    • Author(s)
      Zhao Ming, Tominaga Yohei, Ohuchida Kenoki, Mizumoto Kazuhiro, Cui Lin, Kozono Shingo, Fujita Hayato, Maeyama Ryo, Toma Hiroki, Tanaka Masao.
    • Journal Title

      Cancer Science

      Volume: 103(1) Pages: 58-66

    • Related Report
      2011 Final Research Report
  • [Journal Article] High EGFR mRNA Expression Level is a Prognostic Factor for Reduced Survival in Pancreatic Cancer after Gemcitabine-based Adjuvant Chemotherapy2011

    • Author(s)
      Hayato Fujita, Kenoki Ohuchida, Kazuhiro Mizumoto, Soichi Itaba, Tetsuhide Ito, Kohei Nakata, Jun Yu, Tadashi Kayashima, AkifumiHayashi, Ryota Souzaki, Tatsuro Tajiri, Manabu Onimaru, Tatsuya Manabe, Takao Ohtsuka, Masao Tanaka
    • Journal Title

      International Journal of Oncology

      Volume: 38 Pages: 629-41

    • Related Report
      2011 Final Research Report
  • [Journal Article] Masao Tanaka Insig2 is overexpressed in pancreatic cancer and its expression is induced by hypoxia Cancer Science2011

    • Author(s)
      Tadashi Kayashima, Kohei Nakata, Kenoki Ohuchida, Hayato Fujita, Cui Lin, Kazuhiro Mizumoto
    • Volume
      102
    • Pages
      1137-43
    • Related Report
      2011 Final Research Report
  • [Journal Article] Senescence in intraductal papillary mucinous neoplasm of the pancreas2011

    • Author(s)
      Miyasaka Y, Nagai E, Ohuchida K, Fujita H, Nakata K, Hayashi A, Mizumoto K, Tsuneyoshi M, Tanaka M.
    • Journal Title

      Hum Pathology

      Volume: 42(12) Pages: 2010-7

    • Related Report
      2011 Final Research Report
  • [Journal Article] MicroRNA expression as a predictive marker for gemcitabine response after surgical resection of pancreatic cancer Annals of Surgical Oncology2011

    • Author(s)
      Kenoki Ohuchida, Kazuhiro Mizumoto, Tadashi Kayashima, Midori Sato, Hayato Fujita, Taiki Moriyama, Takao Ohtsuka, Junji Ueda, Shunichi Takahata, Makoto Hashizume, and Masao Tanaka.
    • Volume
      18(8)
    • Pages
      2381-7
    • Related Report
      2011 Final Research Report
  • [Journal Article] Predicting the chemosensitivity of pancreatic cancer cells by quantifying the expression levels of genes associated with the metabolism of gemcitabine and 5-fluorouracil International Journal of Oncology2011

    • Author(s)
      Kurata Nobuaki, Hayato Fujita, Kenoki Ohuchida, Kazuhiro Mizumoto, Prawej Mahawithitwong, Hiroshi Sakai, Manabu Onimaru, Tatsuya Manabe, Takao Ohtsuka, and Masao Tanaka'
    • Volume
      39(2)
    • Pages
      473-82
    • Related Report
      2011 Final Research Report
  • [Journal Article] MicroRNA-10b is overexpressed in pancreatic cancer, promotes its invasiveness and is correlated with a poor prognosis2011

    • Author(s)
      Kohei Nakata, Kenoki Ohuchida, Kazuhiro Mizumoto, Tadashi Kayashima, Naoki Ikenaga, Hiroshi Sakai, Cui Lin, Hayato Fujita, Takao Outsuka, Shinichi Aishima, Eishi Nagai, Yoshinao Oda, and Masao Tanaka.
    • Journal Title

      Surgery

      Volume: 150(5) Pages: 916-22

    • Related Report
      2011 Final Research Report
  • [Journal Article] Adenoviral therapy is more effective in gemcitabine-resistant pancreatic cancer cells than in gemcitabine-sensitive cells2011

    • Author(s)
      Takaharu Yasui, Kenoki Ohuchida, Ming Zhao, Lin Cui, Manabu Onimaru, Takuya Egami, Takao Ohtsuka, Kazuhiro Mizumoto, Kunio Matsumoto, Masao Tanaka
    • Journal Title

      Anticancer Research

      Volume: 31 Pages: 1279-87

    • Related Report
      2011 Final Research Report
  • [Journal Article] Expression of Claudin-4(CLDN4) mRNA in intraductal papillary mucinous neoplasms of the pancreas Modern Pathology2011

    • Author(s)
      Kosuke Tsutsumi, Norihiro Sato, Cui Lin, Kazuhiro Mizumoto, Yoshihiko Sadakari, Hayato Fujita, Kenoki Ohuchida, Shunichi Takahata, and Masao Tanaka
    • Volume
      24
    • Pages
      533-41
    • Related Report
      2011 Final Research Report
  • [Journal Article] Tumor-stromal interactions prevent efficacy of adenoviral therapy via HGF-MET pathway Cancer Science2011

    • Author(s)
      Takaharu Yasui, Kenoki Ohuchida, Chou Mei, Manabu Onimaru, Takuya Egami, Takao Ohtsuka, Kazuhiro Mizumoto, Masao Tanaka
    • Volume
      102
    • Pages
      484-91
    • Related Report
      2011 Final Research Report
  • [Journal Article] MicroRNA-10a is Overexpressed in Human Pancreatic Cancer and Involved in its Invasiveness possibly via Suppression of the HOXA1 gene

    • Author(s)
      Kenoki Ohuchida, Kazuhiro Mizumoto, Cui Lin, Jun Yu, Taiki Moriyama, Yoshiyuki Miyasaka, Hiroshi Yamaguchi, Shunichi Takahata, Hiroki Toma, Norihiro Sato, Eishi Nagai, Makoto Hashizume, and Masao Tanaka
    • Journal Title

      Annals of Surgical Oncolog

    • Related Report
      2011 Final Research Report
  • [Presentation] The Functional Heterogeneity of Pancreatic Cancer Cells and Surrounding Stromal Cells in Cancer-Stromal Interactions2011

    • Author(s)
      Kenoki Ohuchida, Kazuhiro Mizumoto, Masao Tanaka.
    • Organizer
      The 4th International Conference for Treatment of Pancreatic Cancer
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2011-06-25
    • Related Report
      2011 Final Research Report
  • [Presentation] Pancreatic Stellate Cells Promote Migration of CD105+ Pancreatic Cancer Cells. 42nd American Pancreatic Association(APA) Annual Meeting2011

    • Author(s)
      Kenji Fujiwara, Kenoki Ohuchida, Shingo Kozono, Naoki Ikenaga, Lin Cui, Masafumi Nakamura, Kazuhiro Mizumoto, Masao Tanaka.
    • Organizer
      November
    • Place of Presentation
      Chicago, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] 膵癌細胞は癌間質相互作用により細胞外基質コラーゲンを取り込み、浸潤を促進する2011

    • Author(s)
      池永直樹、大内田研宙、小薗真吾、Prawej Mahawithitwong、大塚隆生、水元一博、田中雅夫.
    • Organizer
      22回日本消化器癌発生学会総会
    • Place of Presentation
      佐賀
    • Related Report
      2011 Final Research Report
  • [Presentation] 膵癌細胞株による放射線治療抵抗性と上皮間葉移行の関連性の検討2011

    • Author(s)
      小薗真吾、大内田研宙、高浪英樹、江口大樹、藤原謙次、趙茖、崔林、池永直樹、坂井寛、藤田逸人、大塚隆生、水元一博、田中雅夫.
    • Organizer
      第47回九州外科学会
    • Place of Presentation
      宮崎
    • Related Report
      2011 Final Research Report
  • [Book] 膵癌における癌間質相互作用 特集:膵癌診療と研究の最先端 胆と膵2011

    • Author(s)
      大内田研宙、大塚隆生、水元一博、田中雅夫
    • Related Report
      2011 Final Research Report
  • [Book] Molecular biology-based diagnosis and therapy for pancreatic cancer Fukuoka Igaku Zasshi2011

    • Author(s)
      Fujita H, Ohuchida K, Mizumoto K, Tanaka M
    • Total Pages
      203
    • Related Report
      2011 Final Research Report
  • [Book] 膵癌の分子生物学的解析の現状 腫瘍内科2011

    • Author(s)
      大内田研宙, 藤田逸人、水元一博、田中雅夫
    • Related Report
      2011 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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