Project/Area Number |
23659653
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Digestive surgery
|
Research Institution | Kyushu University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
UEDA Junji 九州大学, 大学病院, 助教 (90529801)
MANABE Tatsuya 九州大学, 医学研究院, 助教 (60546464)
|
Project Period (FY) |
2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
|
Keywords | 膵臓外科学 / 膵癌 / コラーゲンリモデリング / EMT |
Research Abstract |
We identified and characterized CD280 positive pancreatic cancer cells with high malignant potential. Moreover, we clarified that collagen-internalization receptor CD280 was important molecule for invasion of pancreatic cancer cells. We found that the invasion of pancreatic cancer cells was reduced by inhibition of CD280 expression.
|