| Project/Area Number |
23659653
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UEDA Junji 九州大学, 大学病院, 助教 (90529801)
MANABE Tatsuya 九州大学, 医学研究院, 助教 (60546464)
|
|---|
| Project Period (FY) |
2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 膵臓外科学 / 膵癌 / コラーゲンリモデリング / EMT |
|---|
| Research Abstract |
We identified and characterized CD280 positive pancreatic cancer cells with high malignant potential. Moreover, we clarified that collagen-internalization receptor CD280 was important molecule for invasion of pancreatic cancer cells. We found that the invasion of pancreatic cancer cells was reduced by inhibition of CD280 expression.
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