The development of pancreatic cancer therapy based on the new mechanism of pancreatic cancer invasion

• Project/Area Number: 23659653
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Kyushu University
• Principal Investigator: OHUCHIDA Kenoki 九州大学, 医学研究院, 講師 (20452708)
• Co-Investigator(Kenkyū-buntansha): UEDA Junji 九州大学, 大学病院, 助教 (90529801) ; MANABE Tatsuya 九州大学, 医学研究院, 助教 (60546464)
• Project Period (FY): 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
• Keywords: 膵臓外科学 / 膵癌 / コラーゲンリモデリング / EMT

Research Abstract

We identified and characterized CD280 positive pancreatic cancer cells with high malignant potential. Moreover, we clarified that collagen-internalization receptor CD280 was important molecule for invasion of pancreatic cancer cells. We found that the invasion of pancreatic cancer cells was reduced by inhibition of CD280 expression.

Research Products

• [Journal Article] Significance of combination therapy of zoledronic acid and gemcitabine on pancreatic cancer (2012)
  • Author(s): Zhao Ming, Tominaga Yohei, Ohuchida Kenoki, Mizumoto Kazuhiro, Cui Lin, Kozono Shingo, Fujita Hayato, Maeyama Ryo, Toma Hiroki, Tanaka Masao.
  • Journal Title: Cancer Science Volume: 103(1) Pages: 58-66
• [Journal Article] High EGFR mRNA Expression Level is a Prognostic Factor for Reduced Survival in Pancreatic Cancer after Gemcitabine-based Adjuvant Chemotherapy (2011)
  • Author(s): Hayato Fujita, Kenoki Ohuchida, Kazuhiro Mizumoto, Soichi Itaba, Tetsuhide Ito, Kohei Nakata, Jun Yu, Tadashi Kayashima, AkifumiHayashi, Ryota Souzaki, Tatsuro Tajiri, Manabu Onimaru, Tatsuya Manabe, Takao Ohtsuka, Masao Tanaka
  • Journal Title: International Journal of Oncology Volume: 38 Pages: 629-41
• [Journal Article] Masao Tanaka Insig2 is overexpressed in pancreatic cancer and its expression is induced by hypoxia Cancer Science (2011)
  • Author(s): Tadashi Kayashima, Kohei Nakata, Kenoki Ohuchida, Hayato Fujita, Cui Lin, Kazuhiro Mizumoto
  • Volume: 102
  • Pages: 1137-43
• [Journal Article] Senescence in intraductal papillary mucinous neoplasm of the pancreas (2011)
  • Author(s): Miyasaka Y, Nagai E, Ohuchida K, Fujita H, Nakata K, Hayashi A, Mizumoto K, Tsuneyoshi M, Tanaka M.
  • Journal Title: Hum Pathology Volume: 42(12) Pages: 2010-7
• [Journal Article] MicroRNA expression as a predictive marker for gemcitabine response after surgical resection of pancreatic cancer Annals of Surgical Oncology (2011)
  • Author(s): Kenoki Ohuchida, Kazuhiro Mizumoto, Tadashi Kayashima, Midori Sato, Hayato Fujita, Taiki Moriyama, Takao Ohtsuka, Junji Ueda, Shunichi Takahata, Makoto Hashizume, and Masao Tanaka.
  • Volume: 18(8)
  • Pages: 2381-7
• [Journal Article] Predicting the chemosensitivity of pancreatic cancer cells by quantifying the expression levels of genes associated with the metabolism of gemcitabine and 5-fluorouracil International Journal of Oncology (2011)
  • Author(s): Kurata Nobuaki, Hayato Fujita, Kenoki Ohuchida, Kazuhiro Mizumoto, Prawej Mahawithitwong, Hiroshi Sakai, Manabu Onimaru, Tatsuya Manabe, Takao Ohtsuka, and Masao Tanaka'
  • Volume: 39(2)
  • Pages: 473-82
• [Journal Article] MicroRNA-10b is overexpressed in pancreatic cancer, promotes its invasiveness and is correlated with a poor prognosis (2011)
  • Author(s): Kohei Nakata, Kenoki Ohuchida, Kazuhiro Mizumoto, Tadashi Kayashima, Naoki Ikenaga, Hiroshi Sakai, Cui Lin, Hayato Fujita, Takao Outsuka, Shinichi Aishima, Eishi Nagai, Yoshinao Oda, and Masao Tanaka.
  • Journal Title: Surgery Volume: 150(5) Pages: 916-22
• [Journal Article] Adenoviral therapy is more effective in gemcitabine-resistant pancreatic cancer cells than in gemcitabine-sensitive cells (2011)
  • Author(s): Takaharu Yasui, Kenoki Ohuchida, Ming Zhao, Lin Cui, Manabu Onimaru, Takuya Egami, Takao Ohtsuka, Kazuhiro Mizumoto, Kunio Matsumoto, Masao Tanaka
  • Journal Title: Anticancer Research Volume: 31 Pages: 1279-87
• [Journal Article] Expression of Claudin-4(CLDN4) mRNA in intraductal papillary mucinous neoplasms of the pancreas Modern Pathology (2011)
  • Author(s): Kosuke Tsutsumi, Norihiro Sato, Cui Lin, Kazuhiro Mizumoto, Yoshihiko Sadakari, Hayato Fujita, Kenoki Ohuchida, Shunichi Takahata, and Masao Tanaka
  • Volume: 24
  • Pages: 533-41
• [Journal Article] Tumor-stromal interactions prevent efficacy of adenoviral therapy via HGF-MET pathway Cancer Science (2011)
  • Author(s): Takaharu Yasui, Kenoki Ohuchida, Chou Mei, Manabu Onimaru, Takuya Egami, Takao Ohtsuka, Kazuhiro Mizumoto, Masao Tanaka
  • Volume: 102
  • Pages: 484-91
• [Journal Article] MicroRNA-10a is Overexpressed in Human Pancreatic Cancer and Involved in its Invasiveness possibly via Suppression of the HOXA1 gene
  • Author(s): Kenoki Ohuchida, Kazuhiro Mizumoto, Cui Lin, Jun Yu, Taiki Moriyama, Yoshiyuki Miyasaka, Hiroshi Yamaguchi, Shunichi Takahata, Hiroki Toma, Norihiro Sato, Eishi Nagai, Makoto Hashizume, and Masao Tanaka
  • Journal Title: Annals of Surgical Oncolog
• [Presentation] The Functional Heterogeneity of Pancreatic Cancer Cells and Surrounding Stromal Cells in Cancer-Stromal Interactions (2011)
  • Author(s): Kenoki Ohuchida, Kazuhiro Mizumoto, Masao Tanaka.
  • Organizer: The 4th International Conference for Treatment of Pancreatic Cancer
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2011-06-25
• [Presentation] Pancreatic Stellate Cells Promote Migration of CD105+ Pancreatic Cancer Cells. 42nd American Pancreatic Association(APA) Annual Meeting (2011)
  • Author(s): Kenji Fujiwara, Kenoki Ohuchida, Shingo Kozono, Naoki Ikenaga, Lin Cui, Masafumi Nakamura, Kazuhiro Mizumoto, Masao Tanaka.
  • Organizer: November
  • Place of Presentation: Chicago, USA
• [Presentation] 膵癌細胞は癌間質相互作用により細胞外基質コラーゲンを取り込み、浸潤を促進する (2011)
  • Author(s): 池永直樹、大内田研宙、小薗真吾、Prawej Mahawithitwong、大塚隆生、水元一博、田中雅夫.
  • Organizer: 22回日本消化器癌発生学会総会
  • Place of Presentation: 佐賀
• [Presentation] 膵癌細胞株による放射線治療抵抗性と上皮間葉移行の関連性の検討 (2011)
  • Author(s): 小薗真吾、大内田研宙、高浪英樹、江口大樹、藤原謙次、趙茖、崔林、池永直樹、坂井寛、藤田逸人、大塚隆生、水元一博、田中雅夫.
  • Organizer: 第47回九州外科学会
  • Place of Presentation: 宮崎
• [Book] 膵癌における癌間質相互作用 特集:膵癌診療と研究の最先端 胆と膵 (2011)
  • Author(s): 大内田研宙、大塚隆生、水元一博、田中雅夫
• [Book] Molecular biology-based diagnosis and therapy for pancreatic cancer Fukuoka Igaku Zasshi (2011)
  • Author(s): Fujita H, Ohuchida K, Mizumoto K, Tanaka M
  • Total Pages: 203
• [Book] 膵癌の分子生物学的解析の現状 腫瘍内科 (2011)
  • Author(s): 大内田研宙, 藤田逸人、水元一博、田中雅夫