Development of an artificial papillary muscle recovering left ventricular functions

• Project/Area Number: 23659661
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Thoracic surgery
• Research Institution: Tohoku University
• Principal Investigator: SHIRAISHI Yasuyuki 東北大学, 加齢医学研究所, 准教授 (00329137)
• Co-Investigator(Kenkyū-buntansha): YAMBE Tomoyuki 東北大学, 加齢医学研究所, 教授 (70241578)
• Co-Investigator(Renkei-kenkyūsha): MIURA Hidekazu 東北大学, 加齢医学研究所, 助教 (50451894) ; UMEZU Mitsuo 早稲田大学, 先端生命医科学センター, 教 授 (90132927)
• Research Collaborator: HOMMA Dai 株式会社トキ, コーポレーション, 開発部長取締役
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 人工乳頭筋 / 形状記憶合金線維 / 心筋 / 心機能 / ハイブリッド

Research Abstract

We developed an artificial papillary muscle by using covalent-type Ni-Ti anisotropic shape memory fibres. We could achieve the development of a tissue-rubber hybrid left ventricular model including native heart valves. Subsequently we could investigate optimised mechanical interactions between mitral valve leaflets and the left ventricle with the artificial papillary muscle reducing mitral valve regurgitation.

Research Products

• [Journal Article] Effect of a bearing gap on hemolytic property in a hydrodynamically levitated centrifugal blood pump with a semi-open impeller (2013)
  • Author(s): Yambe T, et al.
  • Journal Title: Biomed Mater Eng Volume: 23(1-2) Pages: 37-47
  • Peer Reviewed
• [Journal Article] Examination of mitral regurgitation with a goat heart model for the development of intelligent artificial papillary muscle (2012)
  • Author(s): Shiraishi Y, Yambe T, Hashimoto H, Homma D, et al
  • Journal Title: Conf Proc IEEE Eng Med Biol Soc Volume: 2012 Pages: 6649-52
  • DOI: 10.1109/embc.2012.6347519
  • Peer Reviewed
• [Journal Article] Preliminary Study on Hydraulic Simulation with a Goat Heart for the Development of an Artificial Papillary Muscle (2012)
  • Author(s): Shiraishi Y, et al.
  • Journal Title: 生体医工学 Volume: 50(Suppl.1)
  • Peer Reviewed
• [Journal Article] Examination of mitral regurgitation with a goat heart model for the development of intelligent artificial papillary muscle. (2012)
  • Author(s): Shiraishi Y, et al.
  • Journal Title: Conf Proc IEEE Eng Med Biol Soc Volume: 2012 Pages: 6649-6652
  • Peer Reviewed
• [Journal Article] Preliminary Design of the Mechanical Circulation Assist Device for Fontan Circulation using Shape Memory Alloy Fibers (2012)
  • Author(s): Yamada A, Shiraishi Y, et al.
  • Journal Title: IFMBE Proceedings Volume: 39 Pages: 119-121
  • Peer Reviewed
• [Journal Article] Engineering Approach for the New Circulatory Assist Systems using Shape Memory Alloy Fibre (2012)
  • Author(s): Shiraishi Y, et al.
  • Journal Title: 生体医工学 Volume: 50(Suppl.1)
  • Peer Reviewed
• [Journal Article] Survey of blood pump diaphragm damage in the NIPRO-ventricular assist device (2012)
  • Author(s): Kashiwa K, Nishimura T, Nakahata A, Momose N, Umeda C, Kubo H, Tamai H, Kinugawa K, Adachi H, Yamaguchi A, Yambe T, Katohgi T, Kyo S, Ono M
  • Journal Title: J Artif Organs Volume: 15(4) Pages: 341-346
  • Peer Reviewed
• [Journal Article] Reentrant ventricular outflow tract tachycardia arising from focal scar detected by delayed enhancement magnetic resonance imaging (2012)
  • Author(s): Yamashina Y, Yagi T, Namekawa A, Ishida A, Sato H, Nakagawa T, Sakuramoto M, Sato E, Yambe T
  • Journal Title: Pacing Clin Electrophysiol Volume: 35(12)
  • Peer Reviewed
• [Journal Article] Preliminary study on the development of artificial papillary muscle using shape memory alloy fibre (2012)
  • Author(s): Shiraishi Y, et al.
  • Journal Title: Int J Artif Organs Volume: 35(8) Pages: 597-597
  • Peer Reviewed
• [Journal Article] Engineering analysis of the effects of bulging sinuses in a newly designed pediatric pulmonary heart valve on hemodynamic function (2012)
  • Author(s): I Suzuki, Y Shiraishi, S Yabe, Y Tsuboko, TK Sugai, K Matsue, T Kameyama, Y Saijo, T Tanaka, Y Okamoto, (Z Feng), T Miyazaki, M Yamagishi, M Yoshizawa, M Umezu, T Yambe
  • Journal Title: Journal of Artificial Organs Volume: 15 Issue: 1 Pages: 49-56
  • DOI: 10.1007/s10047-011-0609-1
  • NAID: 10030563380
  • Peer Reviewed
• [Journal Article] Structural design of a newly developed pediatric circulatory assist device for Fontan circulation by using shape memory alloy fiber (2011)
  • Author(s): Shiraishi Y, Yambe T, et al
  • Journal Title: Conf Proc IEEE EMBS Volume: 2011 Pages: 8353-8355
  • DOI: 10.1109/iembs.2011.6092060
  • Peer Reviewed
• [Presentation] Preliminary study on the development of artificial papillary muscle using shape memory alloy fibre (2012)
  • Author(s): Shiraishi Y, Yambe T, Homma D, et al
  • Organizer: XXXIX European Society for Artificial Organs
  • Place of Presentation: ロストック(ドイツ)
  • Year and Date: 2012-09-28
• [Presentation] Study on the development of artificial papillary muscle using shape memory alloy fiber (2012)
  • Author(s): Shiraishi Y, Yambe T, Homma D, et al
  • Organizer: World Congress of Medical Physics and Biomedical Engineering
  • Place of Presentation: 北京(中国)
  • Year and Date: 2012-05-29
• [Presentation] 人工乳頭筋開発のための左心室組織を応用したシミュレーションモデルの開発 (2012)
  • Author(s): 白石泰之、山家智之、本間大, ほか
  • Organizer: 第51回日本生体医工学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-05-11
• [Presentation] 人工心筋の開発状況 (2011)
  • Author(s): 白石泰之
  • Organizer: 第16回心臓外科研究懇話会(招待講演)
  • Place of Presentation: 熱海
• [Presentation] 左室乳頭筋モデルによる僧帽弁機能の基礎検討 (2011)
  • Author(s): 橋本尚、白石泰之、三浦英和、西條芳文、志賀卓弥、古賀千尋、山田昭博、坪子祐佑、山家智之、本間大
  • Organizer: 第45回日本生体医工学会東北支部大会
  • Place of Presentation: 米沢
• [Presentation] 血流のサポート～人工心筋から小児用デバイス開発まで～ (2011)
  • Author(s): 白石泰之
  • Organizer: 第5回日本実験力学会機能性流体研究会(招待講演)
  • Place of Presentation: 秋田
• [Presentation] 小児用肺循環補助装置の駆動方法に関する検討 (2011)
  • Author(s): 山田昭博、白石泰之、Telma K Sugai、三浦英和、古賀千尋、橋本尚、山家智之、山岸正明、本間大
  • Organizer: 第45回日本生体医工学会東北支部大会
  • Place of Presentation: 米沢
• [Presentation] 新しい小児用肺動脈弁改良設計のための逆解析の試み (2011)
  • Author(s): 坪子祐佑、鈴木一郎、白石泰之、山家智之ほか
  • Organizer: 第45回日本生体医工学会東北支部大会
  • Place of Presentation: 米沢
• [Presentation] スマートアクチュエータを利用した人工心筋 (2011)
  • Author(s): 白石泰之、秋山正年、西條芳文、北野智哉、金子芳一、三浦英和、梅津光生、齋木佳克、山家智之
  • Organizer: 第49回日本人工臓器学会大会
  • Place of Presentation: 東京
• [Presentation] 人体を通信媒体とする経皮的情報通信の動物実験評価 (2011)
  • Author(s): 加藤良都、岡本英治、情野和幸、三浦英和、白石泰之、山家智之、三田村好矩
  • Organizer: 第49回日本人工臓器学会大会
  • Place of Presentation: 東京
• [Presentation] 生体僧帽弁モデルを用いた力学検討に基づく人工乳頭筋設計 (2011)
  • Author(s): 橋本尚、白石泰之、Telma Sugai、志賀卓弥、神谷蔵人、Hashem Mohamed、北野智哉、山家智之、本間大
  • Organizer: 第49回日本人工臓器学会大会
  • Place of Presentation: 東京
• [Presentation] 形状記憶合金ファイバーを用いた蠕動運動型人工食道の構造改良と評価 (2011)
  • Author(s): 関根一光、山家智之、白石泰之ほか
  • Organizer: 第50回日本生体医工学会大会
  • Place of Presentation: 東京
• [Presentation] 埋込型遠心型補助人工心臓左心室心尖部挿入カニューレシステム (2011)
  • Author(s): 山家智之
  • Organizer: 第50回日本生体医工学会大会
  • Place of Presentation: 東京
• [Presentation] Artificial muscle for the actuator of the artificial internal organs (2011)
  • Author(s): Yambe T, Shiraishi Y, Miura H, Akiyama M, Saiki Y, Sugai TK
  • Organizer: XXXVIII Annual ESAO & IV Biennial IFAO Congress(招待講演)
  • Place of Presentation: ポルトガル
• [Presentation] Biomedical engineering approach for mechanical circulatory assist using novel shape memory alloy fibres (2011)
  • Author(s): Shiraishi Y, Kaneko Y, Kitano T, Yamada A, Sugai T, Hashimoto H, Omran H, Miura H, Akiyama M, Baba A, Saiki Y, Morita K, Yamagishi M, Yambe T, Homma D
  • Organizer: XXXVIII Annual ESAO & IV Biennial IFAO Congress
  • Place of Presentation: ポルトガル
• [Presentation] 形状記憶合金を応用した人工的循環補助システム開発
  • Author(s): 白石泰之
  • Organizer: 第51回日本生体医工学会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] 人工乳頭筋開発のための左心室組織を応用したシミュレーションモデルの開発
  • Author(s): 白石泰之ほか
  • Organizer: 第51回日本生体医工学会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] 小児人工肺動脈弁機能評価のための新しい右心系模擬循環回路開発
  • Author(s): 坪子侑佑、白石泰之ほか
  • Organizer: 第50回日本人工臓器学会大会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] 心房細動治療のためのPID温度制御法を用いた心房冷却装置開発の基礎検討
  • Author(s): 伊藤拓哉、白石泰之ほか
  • Organizer: 第50回日本人工臓器学会大会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] Study on the Development of Artificial Papillary Muscle Using Shape Memory Alloy Fiber
  • Author(s): Shiraishi Y, et al.
  • Organizer: World Congress of Medical Physics and Biomedical Engineering
  • Place of Presentation: 中国・北京
  • Invited
• [Presentation] Preliminary study on the development of artificial papillary muscle using shape memory alloy fibre
  • Author(s): Shiraishi Y, et al.
  • Organizer: XXXIX Congress of the European Society for Artificial Organs
  • Place of Presentation: ドイツ・ロストック
  • Invited
• [Presentation] Examination of mitral regurgitation with a goat heart model for the development of intelligent artificial papillary muscle.
  • Author(s): Shiraishi Y, et al.
  • Organizer: 34th Annual International Conference of the IEEE Engineering in Medicine & Biology Society
  • Place of Presentation: 米国・サンディエゴ
  • Invited
• [Book] Nano-Biomedical Engineering 2012 (2012)
  • Author(s): Yambe T (Yamaguchi T, ed)
  • Total Pages: 676
  • Publisher: Imperial College Press
• [Remarks] 東北大学加齢医学研究所心臓病電子医学分野
  • URL: http://mec1.idac.tohoku.ac.jp
• [Remarks]
  • URL: http://mec1.idac.tohoku.ac.jp